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PT2638176T - Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização - Google Patents

Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização

Info

Publication number
PT2638176T
PT2638176T PT117853085T PT11785308T PT2638176T PT 2638176 T PT2638176 T PT 2638176T PT 117853085 T PT117853085 T PT 117853085T PT 11785308 T PT11785308 T PT 11785308T PT 2638176 T PT2638176 T PT 2638176T
Authority
PT
Portugal
Prior art keywords
enrichment
ligands
identification
fetal cells
maternal blood
Prior art date
Application number
PT117853085T
Other languages
English (en)
Inventor
Eckelt Andreas
Christensen Britta
Kølvraa Steen
Brinch Marie
Singh Ripudaman
Hatt Lotte
Original Assignee
Arcedi Biotech Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcedi Biotech Aps filed Critical Arcedi Biotech Aps
Publication of PT2638176T publication Critical patent/PT2638176T/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4742Keratin; Cytokeratin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT117853085T 2010-11-09 2011-11-09 Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização PT2638176T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201001018 2010-11-09

Publications (1)

Publication Number Publication Date
PT2638176T true PT2638176T (pt) 2017-10-17

Family

ID=45001595

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117853085T PT2638176T (pt) 2010-11-09 2011-11-09 Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização

Country Status (22)

Country Link
US (1) US9429520B2 (pt)
EP (1) EP2638176B1 (pt)
JP (2) JP6068354B2 (pt)
KR (2) KR20130102612A (pt)
CN (1) CN103261439B (pt)
CA (1) CA2817390C (pt)
CY (1) CY1119526T1 (pt)
DK (1) DK2638176T3 (pt)
EA (1) EA027314B1 (pt)
ES (1) ES2642313T3 (pt)
HR (1) HRP20171468T1 (pt)
HU (1) HUE034937T2 (pt)
IL (1) IL226188A (pt)
LT (1) LT2638176T (pt)
PL (1) PL2638176T3 (pt)
PT (1) PT2638176T (pt)
RS (1) RS56402B1 (pt)
SG (2) SG190175A1 (pt)
SI (1) SI2638176T1 (pt)
SM (1) SMT201700509T1 (pt)
WO (1) WO2012062325A1 (pt)
ZA (1) ZA201303148B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2638176T (pt) * 2010-11-09 2017-10-17 Arcedi Biotech Aps Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização
WO2014067528A1 (en) 2012-10-29 2014-05-08 Arcedi Biotech Aps Improved enrichment and detection of rare blood cells
WO2015118023A1 (en) * 2014-02-05 2015-08-13 Fujirebio Diagnostics Ab Composition and method for detecting malignant neoplastic disease
WO2016021311A1 (ja) * 2014-08-05 2016-02-11 富士フイルム株式会社 有核赤血球の選別方法
US20180015470A1 (en) * 2015-01-23 2018-01-18 Unimed Biotech (Shanghai) Co., Ltd. Microfluidics based fetal cell detection and isolation for non-invasive prenatal testing
CN104977284B (zh) * 2015-07-03 2018-05-29 石莹 一种胎儿有核红细胞的捕获及鉴定方法
CN107475353A (zh) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 肺癌组织溯源ctc分型鉴定试剂盒
CN107475358A (zh) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 结直肠癌组织溯源ctc分型鉴定试剂盒
CN107475354A (zh) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 前列腺癌组织溯源ctc分型鉴定试剂盒
WO2018191194A1 (en) * 2017-04-14 2018-10-18 Rarecyte, Inc. Enrichment and identification of fetal material
CN111122520A (zh) * 2018-10-31 2020-05-08 四川大学华西第二医院 一种胚胎植入检测试剂盒及其应用和使用方法
US20220041991A1 (en) * 2019-01-30 2022-02-10 Dai Nippon Printing Co., Ltd. Cell structure including small intestinal epithelial cells, method for producing same, and substrate holding same
KR20220047929A (ko) * 2019-06-07 2022-04-19 아크에디 바이오테크 에이피에스 Facs를 사용하는 태아 세포의 분리
PH12022550107A1 (en) * 2019-07-15 2022-11-21 A Menarini Biomarkers Singapore Pte Ltd Compositions and methods for isolating, detecting, and analyzing fetal cells
WO2021252595A1 (en) 2020-06-10 2021-12-16 Board Of Regents, The University Of Texas System Method for determining risk of pre-term birth
WO2022165084A1 (en) 2021-01-27 2022-08-04 Biofluidica, Inc. High efficiency capture of fetal cells from maternal samples
WO2023104773A1 (en) * 2021-12-06 2023-06-15 Arcedi Biotech Aps Isolation and diagnostics of fetal cells
CN115109780B (zh) * 2022-06-22 2024-07-05 湖南大学 一种特异性识别并结合循环胎儿有核红细胞的核酸适体、互补序列及它们的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
WO1994002646A1 (en) 1992-07-17 1994-02-03 Aprogenex Inc. Enriching and identyfying fetal cells in maternal blood for in situ hybridization
US5629147A (en) 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5714325A (en) * 1993-09-24 1998-02-03 New England Medical Center Hospitals Prenatal diagnosis by isolation of fetal granulocytes from maternal blood
GB0009179D0 (en) 2000-04-13 2000-05-31 Imp College Innovations Ltd Non-invasive prenatal diagnosis
AU5676701A (en) 2000-05-16 2001-11-26 Kyowa Hakko Kogyo Co. Ltd. Novel method of inducing the differentiation of embryonic stem cells into ectodermal cells and use thereof
AU2002306768A1 (en) 2001-03-20 2002-10-03 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
EP2152905B1 (en) 2007-05-01 2015-12-02 Tel Hashomer Medical Research Infrastructure and Services Ltd. Methods and kits for detecting fetal cells in the maternal blood
WO2009103110A1 (en) 2008-02-18 2009-08-27 Genetic Technologies Limited Cell processing and/or enrichment methods
HRP20150274T1 (hr) 2009-01-07 2015-05-08 Arcedi Biotech Aps Obogaä†ivanje i identifikacija fetalnih stanica u krvi majke i ligandi koji se koriste u tu svrhu
US20100304978A1 (en) 2009-01-26 2010-12-02 David Xingfei Deng Methods and compositions for identifying a fetal cell
WO2010121315A1 (en) 2009-04-22 2010-10-28 Clinical Genomics Pty. Ltd. Method and apparatus for isolating a target bioentity from a biological sample
PT2638176T (pt) * 2010-11-09 2017-10-17 Arcedi Biotech Aps Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização

Also Published As

Publication number Publication date
DK2638176T3 (da) 2017-11-20
EA027314B1 (ru) 2017-07-31
JP2017060525A (ja) 2017-03-30
CA2817390C (en) 2021-02-09
KR20180037308A (ko) 2018-04-11
PL2638176T3 (pl) 2018-01-31
JP2014503193A (ja) 2014-02-13
US9429520B2 (en) 2016-08-30
SG190175A1 (en) 2013-06-28
EA201390638A8 (ru) 2014-01-30
IL226188A (en) 2017-08-31
KR20130102612A (ko) 2013-09-17
ES2642313T3 (es) 2017-11-16
WO2012062325A1 (en) 2012-05-18
CA2817390A1 (en) 2012-05-18
RS56402B1 (sr) 2018-01-31
SI2638176T1 (en) 2018-01-31
CY1119526T1 (el) 2018-03-07
HRP20171468T1 (hr) 2017-12-15
LT2638176T (lt) 2017-11-27
ZA201303148B (en) 2014-01-29
JP6310540B2 (ja) 2018-04-11
JP6068354B2 (ja) 2017-01-25
EP2638176B1 (en) 2017-08-23
HUE034937T2 (en) 2018-03-28
SMT201700509T1 (it) 2017-11-15
KR102057931B1 (ko) 2019-12-20
IL226188A0 (en) 2013-07-31
EA201390638A1 (ru) 2013-09-30
EP2638176A1 (en) 2013-09-18
CN103261439A (zh) 2013-08-21
SG10201509230VA (en) 2015-12-30
US20130331284A1 (en) 2013-12-12
CN103261439B (zh) 2015-04-15

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