PT2638176T - Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização - Google Patents
Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilizaçãoInfo
- Publication number
- PT2638176T PT2638176T PT117853085T PT11785308T PT2638176T PT 2638176 T PT2638176 T PT 2638176T PT 117853085 T PT117853085 T PT 117853085T PT 11785308 T PT11785308 T PT 11785308T PT 2638176 T PT2638176 T PT 2638176T
- Authority
- PT
- Portugal
- Prior art keywords
- enrichment
- ligands
- identification
- fetal cells
- maternal blood
- Prior art date
Links
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 230000001605 fetal effect Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 230000008774 maternal effect Effects 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4742—Keratin; Cytokeratin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201001018 | 2010-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2638176T true PT2638176T (pt) | 2017-10-17 |
Family
ID=45001595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117853085T PT2638176T (pt) | 2010-11-09 | 2011-11-09 | Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9429520B2 (pt) |
| EP (1) | EP2638176B1 (pt) |
| JP (2) | JP6068354B2 (pt) |
| KR (2) | KR20130102612A (pt) |
| CN (1) | CN103261439B (pt) |
| CA (1) | CA2817390C (pt) |
| CY (1) | CY1119526T1 (pt) |
| DK (1) | DK2638176T3 (pt) |
| EA (1) | EA027314B1 (pt) |
| ES (1) | ES2642313T3 (pt) |
| HR (1) | HRP20171468T1 (pt) |
| HU (1) | HUE034937T2 (pt) |
| IL (1) | IL226188A (pt) |
| LT (1) | LT2638176T (pt) |
| PL (1) | PL2638176T3 (pt) |
| PT (1) | PT2638176T (pt) |
| RS (1) | RS56402B1 (pt) |
| SG (2) | SG190175A1 (pt) |
| SI (1) | SI2638176T1 (pt) |
| SM (1) | SMT201700509T1 (pt) |
| WO (1) | WO2012062325A1 (pt) |
| ZA (1) | ZA201303148B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2638176T (pt) * | 2010-11-09 | 2017-10-17 | Arcedi Biotech Aps | Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização |
| WO2014067528A1 (en) | 2012-10-29 | 2014-05-08 | Arcedi Biotech Aps | Improved enrichment and detection of rare blood cells |
| WO2015118023A1 (en) * | 2014-02-05 | 2015-08-13 | Fujirebio Diagnostics Ab | Composition and method for detecting malignant neoplastic disease |
| WO2016021311A1 (ja) * | 2014-08-05 | 2016-02-11 | 富士フイルム株式会社 | 有核赤血球の選別方法 |
| US20180015470A1 (en) * | 2015-01-23 | 2018-01-18 | Unimed Biotech (Shanghai) Co., Ltd. | Microfluidics based fetal cell detection and isolation for non-invasive prenatal testing |
| CN104977284B (zh) * | 2015-07-03 | 2018-05-29 | 石莹 | 一种胎儿有核红细胞的捕获及鉴定方法 |
| CN107475353A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 肺癌组织溯源ctc分型鉴定试剂盒 |
| CN107475358A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 结直肠癌组织溯源ctc分型鉴定试剂盒 |
| CN107475354A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 前列腺癌组织溯源ctc分型鉴定试剂盒 |
| WO2018191194A1 (en) * | 2017-04-14 | 2018-10-18 | Rarecyte, Inc. | Enrichment and identification of fetal material |
| CN111122520A (zh) * | 2018-10-31 | 2020-05-08 | 四川大学华西第二医院 | 一种胚胎植入检测试剂盒及其应用和使用方法 |
| US20220041991A1 (en) * | 2019-01-30 | 2022-02-10 | Dai Nippon Printing Co., Ltd. | Cell structure including small intestinal epithelial cells, method for producing same, and substrate holding same |
| KR20220047929A (ko) * | 2019-06-07 | 2022-04-19 | 아크에디 바이오테크 에이피에스 | Facs를 사용하는 태아 세포의 분리 |
| PH12022550107A1 (en) * | 2019-07-15 | 2022-11-21 | A Menarini Biomarkers Singapore Pte Ltd | Compositions and methods for isolating, detecting, and analyzing fetal cells |
| WO2021252595A1 (en) | 2020-06-10 | 2021-12-16 | Board Of Regents, The University Of Texas System | Method for determining risk of pre-term birth |
| WO2022165084A1 (en) | 2021-01-27 | 2022-08-04 | Biofluidica, Inc. | High efficiency capture of fetal cells from maternal samples |
| WO2023104773A1 (en) * | 2021-12-06 | 2023-06-15 | Arcedi Biotech Aps | Isolation and diagnostics of fetal cells |
| CN115109780B (zh) * | 2022-06-22 | 2024-07-05 | 湖南大学 | 一种特异性识别并结合循环胎儿有核红细胞的核酸适体、互补序列及它们的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641628A (en) | 1989-11-13 | 1997-06-24 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal DNA |
| WO1994002646A1 (en) | 1992-07-17 | 1994-02-03 | Aprogenex Inc. | Enriching and identyfying fetal cells in maternal blood for in situ hybridization |
| US5629147A (en) | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
| US5714325A (en) * | 1993-09-24 | 1998-02-03 | New England Medical Center Hospitals | Prenatal diagnosis by isolation of fetal granulocytes from maternal blood |
| GB0009179D0 (en) | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Non-invasive prenatal diagnosis |
| AU5676701A (en) | 2000-05-16 | 2001-11-26 | Kyowa Hakko Kogyo Co. Ltd. | Novel method of inducing the differentiation of embryonic stem cells into ectodermal cells and use thereof |
| AU2002306768A1 (en) | 2001-03-20 | 2002-10-03 | Ortho-Clinical Diagnostics, Inc. | Expression profiles and methods of use |
| EP2152905B1 (en) | 2007-05-01 | 2015-12-02 | Tel Hashomer Medical Research Infrastructure and Services Ltd. | Methods and kits for detecting fetal cells in the maternal blood |
| WO2009103110A1 (en) | 2008-02-18 | 2009-08-27 | Genetic Technologies Limited | Cell processing and/or enrichment methods |
| HRP20150274T1 (hr) | 2009-01-07 | 2015-05-08 | Arcedi Biotech Aps | Obogaä†ivanje i identifikacija fetalnih stanica u krvi majke i ligandi koji se koriste u tu svrhu |
| US20100304978A1 (en) | 2009-01-26 | 2010-12-02 | David Xingfei Deng | Methods and compositions for identifying a fetal cell |
| WO2010121315A1 (en) | 2009-04-22 | 2010-10-28 | Clinical Genomics Pty. Ltd. | Method and apparatus for isolating a target bioentity from a biological sample |
| PT2638176T (pt) * | 2010-11-09 | 2017-10-17 | Arcedi Biotech Aps | Enriquecimento e identificação de células fetais no sangue materno e ligantes para essa utilização |
-
2011
- 2011-11-09 PT PT117853085T patent/PT2638176T/pt unknown
- 2011-11-09 RS RS20170977A patent/RS56402B1/sr unknown
- 2011-11-09 LT LTEP11785308.5T patent/LT2638176T/lt unknown
- 2011-11-09 ES ES11785308.5T patent/ES2642313T3/es active Active
- 2011-11-09 SG SG2013034756A patent/SG190175A1/en unknown
- 2011-11-09 JP JP2013538070A patent/JP6068354B2/ja active Active
- 2011-11-09 HR HRP20171468TT patent/HRP20171468T1/hr unknown
- 2011-11-09 SG SG10201509230VA patent/SG10201509230VA/en unknown
- 2011-11-09 CA CA2817390A patent/CA2817390C/en active Active
- 2011-11-09 SI SI201131305T patent/SI2638176T1/en unknown
- 2011-11-09 EA EA201390638A patent/EA027314B1/ru unknown
- 2011-11-09 HU HUE11785308A patent/HUE034937T2/en unknown
- 2011-11-09 DK DK11785308.5T patent/DK2638176T3/da active
- 2011-11-09 SM SM20170509T patent/SMT201700509T1/it unknown
- 2011-11-09 CN CN201180056239.5A patent/CN103261439B/zh active Active
- 2011-11-09 EP EP11785308.5A patent/EP2638176B1/en active Active
- 2011-11-09 US US13/883,455 patent/US9429520B2/en active Active
- 2011-11-09 WO PCT/DK2011/050423 patent/WO2012062325A1/en not_active Ceased
- 2011-11-09 KR KR1020137014118A patent/KR20130102612A/ko not_active Ceased
- 2011-11-09 KR KR1020187009057A patent/KR102057931B1/ko active Active
- 2011-11-09 PL PL11785308T patent/PL2638176T3/pl unknown
-
2013
- 2013-04-30 ZA ZA2013/03148A patent/ZA201303148B/en unknown
- 2013-05-06 IL IL226188A patent/IL226188A/en active IP Right Grant
-
2016
- 2016-12-22 JP JP2016249311A patent/JP6310540B2/ja active Active
-
2017
- 2017-10-31 CY CY20171101136T patent/CY1119526T1/el unknown
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