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PT2538968T - Process for production and purification of recombinant lysosomal alpha-mannosidase - Google Patents

Process for production and purification of recombinant lysosomal alpha-mannosidase

Info

Publication number
PT2538968T
PT2538968T PT117058065T PT11705806T PT2538968T PT 2538968 T PT2538968 T PT 2538968T PT 117058065 T PT117058065 T PT 117058065T PT 11705806 T PT11705806 T PT 11705806T PT 2538968 T PT2538968 T PT 2538968T
Authority
PT
Portugal
Prior art keywords
mannosidase
purification
production
recombinant lysosomal
lysosomal alpha
Prior art date
Application number
PT117058065T
Other languages
Portuguese (pt)
Inventor
Fogh Jens
Andersson Claes
Weigelt Cecilia
Hyden Pia
REUTERWALL Helena
Nilsson Stefan
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of PT2538968T publication Critical patent/PT2538968T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477Hemicellulases not provided in a preceding group
    • C12N9/2488Mannanases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024Alpha-mannosidase (3.2.1.24)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Dispersion Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PT117058065T 2010-02-24 2011-02-23 Process for production and purification of recombinant lysosomal alpha-mannosidase PT2538968T (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30758710P 2010-02-24 2010-02-24
DKPA201070067 2010-02-24

Publications (1)

Publication Number Publication Date
PT2538968T true PT2538968T (en) 2018-01-23

Family

ID=43920349

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117058065T PT2538968T (en) 2010-02-24 2011-02-23 Process for production and purification of recombinant lysosomal alpha-mannosidase

Country Status (24)

Country Link
US (3) US8974780B2 (en)
EP (2) EP2538968B1 (en)
JP (1) JP6021647B2 (en)
KR (1) KR101856260B1 (en)
CN (1) CN102834111B (en)
AU (1) AU2011220163B2 (en)
BR (1) BR112012020934B1 (en)
CA (1) CA2790786C (en)
CY (2) CY1123438T1 (en)
DK (2) DK3281636T3 (en)
EA (1) EA022220B1 (en)
ES (1) ES2652330T3 (en)
FR (1) FR18C1038I2 (en)
HR (1) HRP20171736T1 (en)
HU (2) HUE037943T2 (en)
LT (2) LT2538968T (en)
NL (1) NL300948I2 (en)
NO (2) NO2538968T3 (en)
NZ (1) NZ601790A (en)
PL (2) PL2538968T3 (en)
PT (1) PT2538968T (en)
RS (1) RS60983B1 (en)
SI (2) SI2538968T1 (en)
WO (1) WO2011103877A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9310344B2 (en) 2013-06-14 2016-04-12 Dionex Corporation HILIC/anion-exchange/cation-exchange multimodal media
US9169331B2 (en) 2012-12-21 2015-10-27 Dionex Corporation Separation of glycans by mixed-mode liquid chromatography
AR095196A1 (en) 2013-03-15 2015-09-30 Regeneron Pharma SERUM FREE CELL CULTIVATION MEDIA
WO2017051273A1 (en) * 2015-09-22 2017-03-30 Pfizer Inc. Method of preparing a therapeutic protein formulation and antibody formulation produced by such a method
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CN111100196B (en) * 2019-11-08 2021-07-13 上海交通大学 A kind of biologically active polypeptide QILSVPGWTYSR and its preparation method and application
WO2024233992A2 (en) * 2023-05-11 2024-11-14 Trophogen, Inc. Methods of manufacturing highly glycosylated glycoprotein hormones and their analogs

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63327A (en) * 1981-07-16 1985-11-29 Yeda Res & Dev Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
JP4320870B2 (en) 1999-10-18 2009-08-26 住友化学株式会社 (+)-Method for producing trans primary chrysanthemic acid
GB0007651D0 (en) * 2000-03-29 2000-05-17 Ascorbex Ltd Gene sequence
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
WO2002099092A2 (en) 2001-06-07 2002-12-12 Hemebiotech A/S Production of recombinant human lysosomal alpha-mannosidase
JP4742191B2 (en) * 2001-06-14 2011-08-10 独立行政法人産業技術総合研究所 Glycoprotein and method for producing the same
US7507573B2 (en) * 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
NZ589037A (en) * 2004-01-30 2011-10-28 Shire Pharmaceuticals Ireland Ltd Production and purification of recombinant arylsulfatase A
AU2005211775B2 (en) * 2004-02-06 2009-10-08 Biomarin Pharmaceutical Inc. Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
SI1740204T1 (en) * 2004-04-01 2018-07-31 Chiesi Farmaceutici S.P.A. Medicinal use of alpha-mannosidase
CN101410408A (en) 2006-04-04 2009-04-15 希尔制药爱尔兰有限责任公司 Method for concentrating polypeptides
PT2628746T (en) * 2006-04-04 2019-04-23 Chiesi Farm Spa A process for concentration of a polypeptide
KR101293504B1 (en) * 2007-07-11 2013-08-07 노보 노르디스크 에이/에스 Purification of factor viii using a mixed-mode or multimodal resin

Also Published As

Publication number Publication date
DK2538968T3 (en) 2017-12-11
CY1123438T1 (en) 2021-05-05
JP6021647B2 (en) 2016-11-09
EP2538968B1 (en) 2017-11-01
EP2538968A1 (en) 2013-01-02
LTPA2018512I1 (en) 2018-10-10
US20150306186A1 (en) 2015-10-29
CA2790786A1 (en) 2011-09-01
EA201270715A1 (en) 2013-01-30
HUS1800037I1 (en) 2018-09-28
RS60983B1 (en) 2020-11-30
KR101856260B1 (en) 2018-05-09
HUE037943T2 (en) 2018-09-28
LTC2538968I2 (en) 2019-11-11
PL2538968T3 (en) 2018-04-30
EP3281636A1 (en) 2018-02-14
BR112012020934B1 (en) 2021-07-13
ES2652330T3 (en) 2018-02-01
US8974780B2 (en) 2015-03-10
US20180036387A1 (en) 2018-02-08
CY2021002I1 (en) 2021-05-05
EA022220B1 (en) 2015-11-30
FR18C1038I2 (en) 2019-10-11
HRP20171736T1 (en) 2018-01-26
BR112012020934A2 (en) 2017-02-21
SI2538968T1 (en) 2018-04-30
BR112012020934A8 (en) 2018-02-06
NO2538968T3 (en) 2018-03-31
EP3281636B1 (en) 2020-08-05
FR18C1038I1 (en) 2018-11-02
NZ601790A (en) 2014-03-28
SI3281636T1 (en) 2020-11-30
LT2538968T (en) 2018-01-10
JP2013520184A (en) 2013-06-06
US10159718B2 (en) 2018-12-25
CN102834111A (en) 2012-12-19
NL300948I2 (en) 2019-02-27
CN102834111B (en) 2014-11-12
NO2018032I1 (en) 2018-09-14
HK1179869A1 (en) 2013-10-11
PL3281636T3 (en) 2021-03-08
KR20120128647A (en) 2012-11-27
DK3281636T3 (en) 2020-09-21
US20120308549A1 (en) 2012-12-06
AU2011220163A1 (en) 2012-08-30
WO2011103877A1 (en) 2011-09-01
AU2011220163B2 (en) 2015-05-28
CA2790786C (en) 2019-09-24

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