[go: up one dir, main page]

PT2012759E - Derivados de purina como agonistas do receptor a2a - Google Patents

Derivados de purina como agonistas do receptor a2a Download PDF

Info

Publication number
PT2012759E
PT2012759E PT07724375T PT07724375T PT2012759E PT 2012759 E PT2012759 E PT 2012759E PT 07724375 T PT07724375 T PT 07724375T PT 07724375 T PT07724375 T PT 07724375T PT 2012759 E PT2012759 E PT 2012759E
Authority
PT
Portugal
Prior art keywords
receptor agonists
purine derivatives
purine
derivatives
stereoisomers
Prior art date
Application number
PT07724375T
Other languages
English (en)
Inventor
Robin Alec Fairhurst
Roger John Taylor
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2012759E publication Critical patent/PT2012759E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT07724375T 2006-04-21 2007-04-19 Derivados de purina como agonistas do receptor a2a PT2012759E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0607954.5A GB0607954D0 (en) 2006-04-21 2006-04-21 Organic compounds

Publications (1)

Publication Number Publication Date
PT2012759E true PT2012759E (pt) 2010-04-19

Family

ID=36581051

Family Applications (1)

Application Number Title Priority Date Filing Date
PT07724375T PT2012759E (pt) 2006-04-21 2007-04-19 Derivados de purina como agonistas do receptor a2a

Country Status (17)

Country Link
US (1) US20090093633A1 (pt)
EP (1) EP2012759B1 (pt)
JP (1) JP2009534340A (pt)
KR (1) KR20090013790A (pt)
CN (1) CN101426482A (pt)
AT (1) ATE460158T1 (pt)
AU (1) AU2007241346A1 (pt)
BR (1) BRPI0710688A2 (pt)
CA (1) CA2648741A1 (pt)
DE (1) DE602007005241D1 (pt)
ES (1) ES2340886T3 (pt)
GB (1) GB0607954D0 (pt)
MX (1) MX2008013521A (pt)
PL (1) PL2012759T3 (pt)
PT (1) PT2012759E (pt)
RU (1) RU2008145704A (pt)
WO (1) WO2007121923A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607945D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607950D0 (en) 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
RU2457209C2 (ru) 2006-04-21 2012-07-27 Новартис Аг Производные пурина, предназначенные для применения в качестве агонистов аденозинового рецептора а2а
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
RU2009121819A (ru) * 2006-11-10 2010-12-20 Новартис АГ (CH) Производные моноацетата циклопентендиола
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR20100068286A (ko) * 2007-10-17 2010-06-22 노파르티스 아게 아데노신 ａ1 수용체 리간드로서의 퓨린 유도체
ES2676289T3 (es) 2008-06-19 2018-07-18 Takeda Pharmaceutical Company Limited Compuesto heterocíclico y su uso
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2018160824A1 (en) * 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5269628A (en) * 1975-12-08 1977-06-09 Hitachi Ltd Ink jet recorder
EP0550631B1 (en) 1990-09-25 1997-01-02 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
GB9813535D0 (en) 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
GB9813540D0 (en) 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
GB0022695D0 (en) 2000-09-15 2000-11-01 Pfizer Ltd Purine Derivatives
US6505921B2 (en) * 2000-12-28 2003-01-14 Eastman Kodak Company Ink jet apparatus having amplified asymmetric heating drop deflection
US6554410B2 (en) * 2000-12-28 2003-04-29 Eastman Kodak Company Printhead having gas flow ink droplet separation and method of diverging ink droplets
US6588888B2 (en) * 2000-12-28 2003-07-08 Eastman Kodak Company Continuous ink-jet printing method and apparatus
US6457807B1 (en) * 2001-02-16 2002-10-01 Eastman Kodak Company Continuous ink jet printhead having two-dimensional nozzle array and method of redundant printing
US6491362B1 (en) * 2001-07-20 2002-12-10 Eastman Kodak Company Continuous ink jet printing apparatus with improved drop placement
US6827429B2 (en) * 2001-10-03 2004-12-07 Eastman Kodak Company Continuous ink jet printing method and apparatus with ink droplet velocity discrimination
US6851796B2 (en) * 2001-10-31 2005-02-08 Eastman Kodak Company Continuous ink-jet printing apparatus having an improved droplet deflector and catcher
US6793328B2 (en) * 2002-03-18 2004-09-21 Eastman Kodak Company Continuous ink jet printing apparatus with improved drop placement
US6575566B1 (en) * 2002-09-18 2003-06-10 Eastman Kodak Company Continuous inkjet printhead with selectable printing volumes of ink
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607945D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
US20090093633A1 (en) 2009-04-09
MX2008013521A (es) 2008-10-29
ATE460158T1 (de) 2010-03-15
RU2008145704A (ru) 2010-05-27
EP2012759A1 (en) 2009-01-14
EP2012759B1 (en) 2010-03-10
CN101426482A (zh) 2009-05-06
KR20090013790A (ko) 2009-02-05
DE602007005241D1 (de) 2010-04-22
AU2007241346A1 (en) 2007-11-01
CA2648741A1 (en) 2007-11-01
ES2340886T3 (es) 2010-06-10
GB0607954D0 (en) 2006-05-31
JP2009534340A (ja) 2009-09-24
BRPI0710688A2 (pt) 2011-08-23
WO2007121923A1 (en) 2007-11-01
PL2012759T3 (pl) 2010-08-31

Similar Documents

Publication Publication Date Title
PT2012759E (pt) Derivados de purina como agonistas do receptor a2a
WO2007121921A3 (en) Purine derivatives for use as adenosin a2a receptor agonists
WO2007121918A3 (en) Use of 2-(purin-9-yl)-tetrahydofuran-3,4-diol derivatives as adenosine a2a receptor agonists
TN2009000084A1 (en) Adenosine derivatives as a2a receptor agonists
MY146645A (en) Purine derivatives for use as adenosin a2a receptor agonists
MX2009000169A (es) Derivados de purinona como agonistas de hm74a.
UA107649C2 (uk) Ізоксазол-ліганди метаботропного рецептора глутамату та їх застосування як потенціаторів
MY153985A (en) Aminotriazole derivatives as alx agonists
MX2009011802A (es) Imidazoquinolinas con propiedades inmunomoduladoras.
MX2011011136A (es) Eteres diarilicos.
MX2010004435A (es) Compuestos espiro y uso farmaceutico de los mismos.
WO2007121924A3 (en) Bisadenosine compounds as adenosine a2a receptor agonists
TNSN08544A1 (en) Purine derivatives as a2a agonists
TNSN08326A1 (en) Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
NO20085257L (no) Purinonderivater som HM74a-agonister
MX2008013520A (es) Agonistas del receptor de adenosina a3.
MX2008013522A (es) Derivados de purina como activadores del receptor de adenosina.
MX2011011733A (es) Inhiibidores de dihidroorotato deshidrogenasa como compuestos virostaticos.
EA200970669A1 (ru) Производные 2-амино-5,7-дигидро-6н-пирроло[3,4-d]пиримидина в качестве ингибиторов hsp-90, предназначенные для лечения рака
MX2011012639A (es) Sales de derivados de pirazolon azo sustituidos con biciclo, metodo de preparacion y uso de los mismos.
MY149854A (en) Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
ATE496918T1 (de) Als a2b-adenosinrezeptorantagonisten geeignete 5- phenyl-6-pyridin-4-yl-1,3-dihydro-2h-imidazoä4, - büpyridin-2-onderivate
UA97256C2 (ru) Замещенные пиразолы и триазолы как ингибиторы кбв (кинезин-белок веретена)
TNSN08369A1 (en) Benzimidazole derivatives
MY161749A (en) Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use