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PT1639011E - Anticorpos (dab) de domínio único peguilados - Google Patents

Anticorpos (dab) de domínio único peguilados Download PDF

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Publication number
PT1639011E
PT1639011E PT04737302T PT04737302T PT1639011E PT 1639011 E PT1639011 E PT 1639011E PT 04737302 T PT04737302 T PT 04737302T PT 04737302 T PT04737302 T PT 04737302T PT 1639011 E PT1639011 E PT 1639011E
Authority
PT
Portugal
Prior art keywords
variable domain
dab
single domain
domain antibodies
polypeptide
Prior art date
Application number
PT04737302T
Other languages
English (en)
Inventor
Amrik Basran
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35811376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1639011(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/GB2003/002804 external-priority patent/WO2004003019A2/en
Application filed by Domantis Ltd filed Critical Domantis Ltd
Publication of PT1639011E publication Critical patent/PT1639011E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/567—Framework region [FR]
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K—PEPTIDES
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Hematology (AREA)
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  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
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  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
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  • Pain & Pain Management (AREA)
  • Neurology (AREA)
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  • Transplantation (AREA)
PT04737302T 2003-06-30 2004-06-30 Anticorpos (dab) de domínio único peguilados PT1639011E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2003/002804 WO2004003019A2 (en) 2002-06-28 2003-06-30 Immunoglobin single variant antigen-binding domains and dual-specific constructs
US50961303P 2003-10-08 2003-10-08
US53507604P 2004-01-08 2004-01-08

Publications (1)

Publication Number Publication Date
PT1639011E true PT1639011E (pt) 2009-01-20

Family

ID=35811376

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04737302T PT1639011E (pt) 2003-06-30 2004-06-30 Anticorpos (dab) de domínio único peguilados

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Country Link
US (4) US20060286066A1 (pt)
EP (3) EP1639011B1 (pt)
JP (2) JP5087274B2 (pt)
CN (1) CN1845938B (pt)
AT (1) ATE414106T1 (pt)
AU (3) AU2004220325B2 (pt)
CA (2) CA2529819A1 (pt)
CY (1) CY1108691T1 (pt)
DE (1) DE602004017726D1 (pt)
DK (1) DK1639011T3 (pt)
ES (1) ES2315664T3 (pt)
PL (1) PL1639011T3 (pt)
PT (1) PT1639011E (pt)
SI (1) SI1639011T1 (pt)
WO (2) WO2004081026A2 (pt)
ZA (1) ZA200702879B (pt)

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CA2529819A1 (en) 2004-09-23
EP1639011A2 (en) 2006-03-29
CN1845938A (zh) 2006-10-11
WO2004081026A3 (en) 2005-01-27
PL1639011T3 (pl) 2009-05-29
EP2221317A3 (en) 2011-07-27
WO2005035572A3 (en) 2007-01-04
US20090148434A1 (en) 2009-06-11
SI1639011T1 (sl) 2009-04-30
EP1720906A2 (en) 2006-11-15
ES2315664T3 (es) 2009-04-01
CA2539999A1 (en) 2005-04-21
AU2004280288A1 (en) 2005-04-21
CN1845938B (zh) 2010-05-26
AU2004280288B2 (en) 2007-02-01
JP2008500268A (ja) 2008-01-10
AU2004220325A1 (en) 2004-09-23
JP2007516195A (ja) 2007-06-21
AU2011200930B2 (en) 2013-10-24
WO2004081026A2 (en) 2004-09-23
AU2004280288A2 (en) 2005-04-21
ATE414106T1 (de) 2008-11-15
US20070065440A1 (en) 2007-03-22
ZA200702879B (en) 2008-08-27
US20090082550A1 (en) 2009-03-26
DE602004017726D1 (de) 2008-12-24
WO2005035572A2 (en) 2005-04-21
DK1639011T3 (da) 2009-02-16
EP2221317A2 (en) 2010-08-25
US20060286066A1 (en) 2006-12-21
JP5087274B2 (ja) 2012-12-05
EP1639011B1 (en) 2008-11-12
AU2011200930A1 (en) 2011-03-24
CY1108691T1 (el) 2014-04-09
AU2004220325B2 (en) 2011-05-12

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