PT1390525E - Piruvato-quinase como uma nova molécula alvo - Google Patents
Piruvato-quinase como uma nova molécula alvo Download PDFInfo
- Publication number
- PT1390525E PT1390525E PT02748716T PT02748716T PT1390525E PT 1390525 E PT1390525 E PT 1390525E PT 02748716 T PT02748716 T PT 02748716T PT 02748716 T PT02748716 T PT 02748716T PT 1390525 E PT1390525 E PT 1390525E
- Authority
- PT
- Portugal
- Prior art keywords
- pyruvate
- kinase
- target molecule
- novel target
- target
- Prior art date
Links
- 102000013009 Pyruvate Kinase Human genes 0.000 title abstract 2
- 108020005115 Pyruvate Kinase Proteins 0.000 title abstract 2
- MJKYGUXBFYGLLM-UHFFFAOYSA-N cyclohexanamine;2-phosphonooxyprop-2-enoic acid Chemical compound NC1CCCCC1.NC1CCCCC1.NC1CCCCC1.OC(=O)C(=C)OP(O)(O)=O MJKYGUXBFYGLLM-UHFFFAOYSA-N 0.000 title abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112601 | 2001-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1390525E true PT1390525E (pt) | 2008-11-25 |
Family
ID=8177529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02748716T PT1390525E (pt) | 2001-05-23 | 2002-05-23 | Piruvato-quinase como uma nova molécula alvo |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040152648A1 (pt) |
| EP (2) | EP1990422A1 (pt) |
| AT (1) | ATE404691T1 (pt) |
| AU (1) | AU2002319180B2 (pt) |
| CA (1) | CA2448165A1 (pt) |
| DE (1) | DE60228233D1 (pt) |
| DK (1) | DK1390525T3 (pt) |
| ES (1) | ES2312595T3 (pt) |
| PT (1) | PT1390525E (pt) |
| WO (1) | WO2002095063A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003266272A1 (en) * | 2002-08-12 | 2004-03-03 | Amynon Bio Tech Gmbh | Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk) |
| JP2006517788A (ja) * | 2002-12-20 | 2006-08-03 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 15986、2188、20743、9148、9151、9791、44252、14184、42461、8204、7970、25552、21657、26492、2411、15088、1905、28899、63380、33935、10480、12686、25501、17694、15701、53062、49908、21612、38949、6216、46863、9235、2201、6985、9883、12238、18057、21617、39228、49928、54476、62113、64316、12264、32362、58198、2887、3205、8557、9600、9693、44867、53058、55556、57658、2208、10252、10302、14218、33877、10317、10485、25964、14815、1363、1397、14827、21708、3801、64698、2179または13249を使用する癌を処置するための方法および組成物 |
| DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
| WO2006055880A2 (en) * | 2004-11-16 | 2006-05-26 | Genzyme Corporation | Diagnostic pkm2 methods and compositions |
| US20060166236A1 (en) * | 2004-12-15 | 2006-07-27 | Chong-Sheng Yuan | Allosteric enzyme coupled immunoassay (AECIA) |
| WO2009025781A1 (en) * | 2007-08-16 | 2009-02-26 | Beth Israel Deaconess Medical Center | Activators of pyruvate kinase m2 and methods of treating disease |
| AU2009303335B2 (en) * | 2008-10-09 | 2016-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
| CA2758071C (en) | 2009-04-06 | 2018-01-09 | Agios Pharmaceuticals, Inc. | Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use |
| CA2760929C (en) | 2009-05-04 | 2018-01-02 | Agios Pharmaceuticals, Inc. | Pkm2 activators for use in the treatment of cancer |
| NZ597379A (en) | 2009-06-29 | 2014-04-30 | Agios Pharmaceuticals Inc | Therapeutic compounds and compositions |
| ES2618630T3 (es) | 2009-06-29 | 2017-06-21 | Agios Pharmaceuticals, Inc. | Composiciones terapéuticas y métodos de uso relacionados |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| CA2793836C (en) | 2009-10-21 | 2020-03-24 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| WO2011109823A1 (en) | 2010-03-05 | 2011-09-09 | The Trustees Of Columbia University In The City Of New York | Inhibitory rnas to rna binding proteins hnrnpa1, hnrnpa2 and ptb and uses thereof |
| JP2013525438A (ja) | 2010-04-29 | 2013-06-20 | アメリカ合衆国 | ヒトピルビン酸キナーゼ活性剤 |
| EP2651898B1 (en) | 2010-12-17 | 2015-12-09 | Agios Pharmaceuticals, Inc. | Novel n-(4-(azetidine-1-carbonyl)phenyl)-(hetero-)arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators |
| US9328077B2 (en) | 2010-12-21 | 2016-05-03 | Agios Pharmaceuticals, Inc | Bicyclic PKM2 activators |
| TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| SMT201800354T1 (it) | 2011-05-03 | 2018-09-13 | Agios Pharmaceuticals Inc | Attivatori della piruvato chinasi per uso in terapia |
| US11234976B2 (en) | 2015-06-11 | 2022-02-01 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
| SMT201900517T1 (it) | 2017-03-20 | 2019-11-13 | Forma Therapeutics Inc | Composizioni di pirrolopirrolo come attivatori di piruvato chinasi (pkr) |
| CN113226356B (zh) | 2018-09-19 | 2025-03-04 | 诺沃挪第克健康护理股份公司 | 活化丙酮酸激酶r |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| CN114615977B (zh) | 2019-09-19 | 2025-01-14 | 诺沃挪第克健康护理股份公司 | 丙酮酸激酶r(pkr)活化组合物 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821254A (en) * | 1995-02-17 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer |
| WO1998035032A2 (en) * | 1997-02-11 | 1998-08-13 | The Regents Of The University Of California | Methods of inducing cell cycle stasis |
| US7074895B2 (en) * | 1997-08-21 | 2006-07-11 | Quark Biotech, Inc. | Sequences characteristic of hypoxia-regulated gene transcription |
| US5948628A (en) * | 1997-09-05 | 1999-09-07 | The Board Of Regents Of The University Of Oklahoma | Methods of screening for compounds which mimic galectin-1 |
| US6458538B1 (en) * | 1999-12-14 | 2002-10-01 | Ptc Therapeutics, Inc. | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay |
-
2002
- 2002-05-23 ES ES02748716T patent/ES2312595T3/es not_active Expired - Lifetime
- 2002-05-23 PT PT02748716T patent/PT1390525E/pt unknown
- 2002-05-23 EP EP08014232A patent/EP1990422A1/en not_active Withdrawn
- 2002-05-23 WO PCT/EP2002/005684 patent/WO2002095063A1/en not_active Ceased
- 2002-05-23 EP EP02748716A patent/EP1390525B8/en not_active Expired - Lifetime
- 2002-05-23 DK DK02748716T patent/DK1390525T3/da active
- 2002-05-23 AT AT02748716T patent/ATE404691T1/de not_active IP Right Cessation
- 2002-05-23 CA CA002448165A patent/CA2448165A1/en not_active Abandoned
- 2002-05-23 US US10/478,679 patent/US20040152648A1/en not_active Abandoned
- 2002-05-23 AU AU2002319180A patent/AU2002319180B2/en not_active Ceased
- 2002-05-23 DE DE60228233T patent/DE60228233D1/de not_active Expired - Lifetime
-
2007
- 2007-06-29 US US11/771,462 patent/US20080021116A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1390525B8 (en) | 2009-03-04 |
| DK1390525T3 (da) | 2008-12-08 |
| ATE404691T1 (de) | 2008-08-15 |
| EP1990422A1 (en) | 2008-11-12 |
| ES2312595T3 (es) | 2009-03-01 |
| US20080021116A1 (en) | 2008-01-24 |
| EP1390525A1 (en) | 2004-02-25 |
| DE60228233D1 (de) | 2008-09-25 |
| WO2002095063A1 (en) | 2002-11-28 |
| CA2448165A1 (en) | 2002-11-28 |
| EP1390525B1 (en) | 2008-08-13 |
| AU2002319180B2 (en) | 2007-07-05 |
| US20040152648A1 (en) | 2004-08-05 |
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