PT1228073E - Compostos de imidazol como inibidores de fosfodiesterase - Google Patents

Compostos de imidazol como inibidores de fosfodiesterase

Info

Publication number: PT1228073E
Authority: PT; Portugal
Prior art keywords: imidazole compounds; phosphodiesterase inhibitors; phosphodiesterase; inhibitors; imidazole
Prior art date: 1999-11-13

Application number

PT00975978T

Other languages

English (en)

Inventor

Rochus Jonas

Hans Michael Eggenweiler

Michael Wolf

Michael Gassen

Thomas Welge

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-13

Filing date

2000-10-31

Publication date

2003-12-31

2000-10-31 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-12-31 Publication of PT1228073E publication Critical patent/PT1228073E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Obesity (AREA)
AIDS & HIV (AREA)

PT00975978T 1999-11-13 2000-10-31 Compostos de imidazol como inibidores de fosfodiesterase PT1228073E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19954707A DE19954707A1 (de)	1999-11-13	1999-11-13	Imidazolverbindungen als Phosphodiesterase VII-Hemmer

Publications (1)

Publication Number	Publication Date
PT1228073E true PT1228073E (pt)	2003-12-31

Family

ID=7928973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT00975978T PT1228073E (pt)	1999-11-13	2000-10-31	Compostos de imidazol como inibidores de fosfodiesterase

Country Status (23)

Country	Link
US (1)	US6884800B1 (pt)
EP (1)	EP1228073B1 (pt)
JP (1)	JP4819272B2 (pt)
KR (1)	KR20020049051A (pt)
CN (1)	CN1390222A (pt)
AR (1)	AR026421A1 (pt)
AT (1)	ATE245653T1 (pt)
AU (1)	AU775886B2 (pt)
BR (1)	BR0015487A (pt)
CA (1)	CA2391087A1 (pt)
CZ (1)	CZ20021474A3 (pt)
DE (2)	DE19954707A1 (pt)
DK (1)	DK1228073T3 (pt)
ES (1)	ES2200968T3 (pt)
HU (1)	HUP0203422A3 (pt)
MX (1)	MXPA02004728A (pt)
NO (1)	NO20022232L (pt)
PL (1)	PL355098A1 (pt)
PT (1)	PT1228073E (pt)
RU (1)	RU2002113759A (pt)
SK (1)	SK6012002A3 (pt)
WO (1)	WO2001036425A2 (pt)
ZA (1)	ZA200204729B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2217956B1 (es) *	2003-01-23	2006-04-01	Almirall Prodesfarma, S.A.	Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
EP2275096A3 (en)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenesis via modulation of the muscarinic receptors
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1940389A2 (en)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
JP2009513672A (ja)	2005-10-31	2009-04-02	ブレインセルス，インコーポレイティド	神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
CA2651862A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2382975A3 (en)	2006-05-09	2012-02-29	Braincells, Inc.	Neurogenesis by modulating angiotensin
KR20090064418A (ko)	2006-09-08	2009-06-18	브레인셀즈 인코퍼레이션	4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
CN104758291B (zh) *	2007-03-27	2020-03-03	奥默罗斯公司	用于治疗运动障碍的pde7抑制剂的用途
DE102007047738A1 (de) *	2007-10-05	2009-04-09	Merck Patent Gmbh	Imidazolderivate
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
CA2817071C (en)	2010-11-08	2018-04-24	Omeros Corporation	Treatment of addiction and impulse-control disorders using pde7 inhibitors
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
WO2019014305A1 (en)	2017-07-12	2019-01-17	Dart Neuroscience, Llc	SUBSTITUTED BENZOXAZOLE AND BENZOFURAN COMPOUNDS AS PDE7 INHIBITORS
CA3264513A1 (en)	2022-08-18	2024-02-22	Mitodicure Gmbh	USE OF SUBSTITUTED BENZOFURAN AND BENZOXAZOLE COMPOUNDS FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH CHRONIC FATIGUE, EXHAUSTION AND/OR EXERCISE INTOLERANCE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2919271A (en) *	1957-12-05	1959-12-29	Smith Kline French Lab	3-amino-1, 2-dihydro-3h-pyrido [3, 2, 1-kl]-phenothiazines
AU626427B2 (en) *	1989-06-09	1992-07-30	Pharmacia & Upjohn Company	Heterocyclic amines having central nervous system activity
US5318965A (en) *	1990-08-24	1994-06-07	Abbott Laboratories	Quinobenzoxazine, antineoplastic agents
ZA9810766B (en) *	1997-11-28	1999-05-25	Mochida Pharm Co Ltd	Novel compounds having cgmp-pde inhibitory activity

1999
- 1999-11-13 DE DE19954707A patent/DE19954707A1/de not_active Withdrawn
2000
- 2000-10-31 AU AU13907/01A patent/AU775886B2/en not_active Ceased
- 2000-10-31 CZ CZ20021474A patent/CZ20021474A3/cs unknown
- 2000-10-31 CN CN00815534A patent/CN1390222A/zh active Pending
- 2000-10-31 JP JP2001538914A patent/JP4819272B2/ja not_active Expired - Fee Related
- 2000-10-31 WO PCT/EP2000/010765 patent/WO2001036425A2/de not_active Ceased
- 2000-10-31 BR BR0015487-3A patent/BR0015487A/pt not_active Application Discontinuation
- 2000-10-31 CA CA002391087A patent/CA2391087A1/en not_active Abandoned
- 2000-10-31 SK SK601-2002A patent/SK6012002A3/sk unknown
- 2000-10-31 RU RU2002113759/04A patent/RU2002113759A/ru unknown
- 2000-10-31 DK DK00975978T patent/DK1228073T3/da active
- 2000-10-31 PL PL00355098A patent/PL355098A1/xx unknown
- 2000-10-31 MX MXPA02004728A patent/MXPA02004728A/es not_active Application Discontinuation
- 2000-10-31 PT PT00975978T patent/PT1228073E/pt unknown
- 2000-10-31 US US10/129,629 patent/US6884800B1/en not_active Expired - Fee Related
- 2000-10-31 ES ES00975978T patent/ES2200968T3/es not_active Expired - Lifetime
- 2000-10-31 KR KR1020027006131A patent/KR20020049051A/ko not_active Withdrawn
- 2000-10-31 AT AT00975978T patent/ATE245653T1/de not_active IP Right Cessation
- 2000-10-31 DE DE50003036T patent/DE50003036D1/de not_active Expired - Lifetime
- 2000-10-31 HU HU0203422A patent/HUP0203422A3/hu unknown
- 2000-10-31 EP EP00975978A patent/EP1228073B1/de not_active Expired - Lifetime
- 2000-11-10 AR ARP000105929A patent/AR026421A1/es unknown
2002
- 2002-05-10 NO NO20022232A patent/NO20022232L/no not_active Application Discontinuation
- 2002-06-12 ZA ZA200204729A patent/ZA200204729B/en unknown

Also Published As

Publication number	Publication date
MXPA02004728A (es)	2002-08-30
CA2391087A1 (en)	2001-05-25
HUP0203422A2 (hu)	2003-02-28
KR20020049051A (ko)	2002-06-24
ZA200204729B (en)	2003-11-26
SK6012002A3 (en)	2002-09-10
CZ20021474A3 (cs)	2002-07-17
DK1228073T3 (da)	2003-11-03
AU1390701A (en)	2001-05-30
AR026421A1 (es)	2003-02-12
NO20022232D0 (no)	2002-05-10
EP1228073B1 (de)	2003-07-23
RU2002113759A (ru)	2004-01-10
EP1228073A2 (de)	2002-08-07
AU775886B2 (en)	2004-08-19
NO20022232L (no)	2002-05-10
WO2001036425A2 (de)	2001-05-25
HUP0203422A3 (en)	2004-12-28
JP2003514821A (ja)	2003-04-22
US6884800B1 (en)	2005-04-26
DE50003036D1 (de)	2003-08-28
ATE245653T1 (de)	2003-08-15
JP4819272B2 (ja)	2011-11-24
WO2001036425A3 (de)	2002-01-10
DE19954707A1 (de)	2001-05-17
CN1390222A (zh)	2003-01-08
BR0015487A (pt)	2002-07-02
PL355098A1 (en)	2004-04-05
ES2200968T3 (es)	2004-03-16

Publication	Publication Date	Title
PT1228073E (pt)	2003-12-31	Compostos de imidazol como inibidores de fosfodiesterase
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PT1144403E (pt)	2005-01-31	Pirazoles substituidos como inibidores de p38 quinase
EE200300049A (et)	2004-10-15	Imidasooli derivaadid
DE60018989D1 (de)	2005-04-28	N-carbamoyloxyalkyl-substituierte azolium-verbindungen
PT1244647E (pt)	2006-10-31	Derivados de quinazolina como inibidores de vegf
ATE349447T1 (de)	2007-01-15	Alkylamino-substituierte bicyclische heterocyclen als p38 protein kinase inhibitoren
NO20015650D0 (no)	2001-11-20	Pyrrolotriazin-inhibitorer for kinaser
ATE360620T1 (de)	2007-05-15	Imidazolderivate
AR028576A1 (es)	2003-05-14	Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa
ATE425147T1 (de)	2009-03-15	Imidazolderivate
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ATE339403T1 (de)	2006-10-15	Pyrrolderivate als phosphodiesterase vii-hemmer
PT1212320E (pt)	2005-11-30	Fenilpiperazinas como inibidores de reabsorcao de serotonina
PT1226143E (pt)	2003-08-29	Derivados de imidazopiridina como inibidores da fosfodiesterase vii
PT1401828E (pt)	2006-08-31	Compostos de n-formil-hidroxilamina como inibidores de pdf
PT1189907E (pt)	2005-05-31	Tienopirimidinas como inibidores da fosfodiesterase
DZ3244A1 (fr)	2001-06-28	Inhibiteurs de 8-arylquinoline phosphodiesterase-4 substituee
PT1222193E (pt)	2003-12-31	Derivados de imidazol como inibidores da fosfodiesterase
DE60003045D1 (de)	2003-07-03	Heterozyclische verbindungen als angiogenese inhibitoren
ATE280161T1 (de)	2004-11-15	Imidazolverbindungen als alpha2-adrenorezeptoren antagonisten