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PT1295890E - Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao - Google Patents

Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao

Info

Publication number
PT1295890E
PT1295890E PT02028152T PT02028152T PT1295890E PT 1295890 E PT1295890 E PT 1295890E PT 02028152 T PT02028152 T PT 02028152T PT 02028152 T PT02028152 T PT 02028152T PT 1295890 E PT1295890 E PT 1295890E
Authority
PT
Portugal
Prior art keywords
salts
production
contain
pyrazine derivatives
compounds
Prior art date
Application number
PT02028152T
Other languages
English (en)
Inventor
Egawa Hiroyuki
Furuta Yousuke
Jun Sugita
Uehara Sayuri
Hamamoto Shoichi
Yonezawa Kenji
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of PT1295890E publication Critical patent/PT1295890E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT02028152T 2000-02-16 2001-02-14 Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao PT1295890E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000037486 2000-02-16
JP2000040439 2000-02-18
JP2000090071 2000-03-29

Publications (1)

Publication Number Publication Date
PT1295890E true PT1295890E (pt) 2005-06-30

Family

ID=27342371

Family Applications (2)

Application Number Title Priority Date Filing Date
PT01904434T PT1256588E (pt) 2000-02-16 2001-02-14 Derivados de pirazina originais ou os seus sais, preparacoes farmaceuticas, contendo os derivados ou os seus sais e produtos intermedios para a preparacao de ambos
PT02028152T PT1295890E (pt) 2000-02-16 2001-02-14 Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT01904434T PT1256588E (pt) 2000-02-16 2001-02-14 Derivados de pirazina originais ou os seus sais, preparacoes farmaceuticas, contendo os derivados ou os seus sais e produtos intermedios para a preparacao de ambos

Country Status (15)

Country Link
US (1) US6800629B2 (pt)
EP (2) EP1256588B1 (pt)
JP (2) JP4379767B2 (pt)
KR (3) KR100604955B1 (pt)
CN (1) CN1239511C (pt)
AT (2) ATE294185T1 (pt)
AU (1) AU2001232287A1 (pt)
BR (2) BRPI0116967B8 (pt)
CA (1) CA2398620C (pt)
DE (2) DE60110415T2 (pt)
DK (1) DK1295890T3 (pt)
ES (2) ES2240645T3 (pt)
MX (1) MXPA02007890A (pt)
PT (2) PT1256588E (pt)
WO (1) WO2001060834A1 (pt)

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* Cited by examiner, † Cited by third party
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WO2003015798A1 (fr) * 2001-08-14 2003-02-27 Toyama Chemical Co., Ltd. Nouvelle methode virocide/inhibitrice de la proliferation virale et nouvel analogue de pyradine nucleotide/pyradine nucleoside
EP1804811A4 (en) * 2004-09-24 2011-04-27 Idenix Cayman Ltd METHOD AND COMPOSITION FOR THE TREATMENT OF FLAVIVERS, PESTIVERS AND HEPACIVIRES
EP2545923A1 (en) * 2005-12-22 2013-01-16 Alchemia Limited Antibacterial agents
WO2007139081A1 (ja) * 2006-05-31 2007-12-06 Toyama Chemical Co., Ltd. イノシシ科動物またはヒツジ用抗口蹄疫ウイルス剤およびイノシシ科動物またはヒツジの口蹄疫の予防または治療方法
BRPI0817305B1 (pt) * 2007-09-27 2021-10-19 Fujifilm Toyama Chemical Co., Ltd. Sal de dicicloexilamina, e, processo para produzir um sal de dicicloexilamina
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法
JP5385309B2 (ja) * 2009-01-28 2014-01-08 日本曹達株式会社 ジクロロピラジン誘導体の製造方法
JP5559604B2 (ja) * 2009-05-27 2014-07-23 富山化学工業株式会社 ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法
ES2554630T3 (es) 2010-09-30 2015-12-22 Toyama Chemical Co., Ltd. Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida
SI2623497T1 (sl) 2010-09-30 2016-04-29 Toyama Chemical Co., Ltd. Megluminska sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida
KR101902857B1 (ko) * 2010-11-12 2018-10-01 후지필름 가부시키가이샤 피라지노〔2,3-ｄ〕이소옥사졸 유도체
CN102846617B (zh) * 2011-07-01 2016-01-13 中国人民解放军军事医学科学院毒物药物研究所 3－(丁基氧基)－2－吡嗪甲酰氨的制备方法和用途
CN102850282B (zh) * 2011-07-01 2015-09-16 中国人民解放军军事医学科学院毒物药物研究所 3-取代氧基-2-吡嗪甲酰胺类化合物及其用途
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
WO2016172205A1 (en) * 2015-04-20 2016-10-27 Emory University Managing ebola viral infections
HRP20211070T1 (hr) 2015-06-09 2021-10-01 Fujifilm Toyama Chemical Co., Ltd. 6-bromo-3-hidroksi-2-pirazinkarboksamid kristal i postupak za proizvodnju
CN104961691A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(2-氟苯氧基)吡嗪-2-羧酸的制备方法
CN104961690A (zh) * 2015-07-11 2015-10-07 长沙深橙生物科技有限公司 3-(4-氟苯氧基)吡嗪-2-羧酸的制备方法
CN105017166A (zh) * 2015-07-11 2015-11-04 长沙深橙生物科技有限公司 3-(3-溴苯氧基)吡嗪-2-羧酸的制备方法
CN105037281A (zh) * 2015-07-11 2015-11-11 长沙深橙生物科技有限公司 3-(3-氟苯氧基)吡嗪-2-羧酸的制备方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
CN110678473A (zh) * 2017-04-25 2020-01-10 大原药品工业株式会社 核苷类抗癌药或抗病毒药的5’位二苄基单磷酸酯衍生物
CN111265528A (zh) 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
WO2021255681A1 (en) * 2020-06-17 2021-12-23 Hikal Limited A simple process for the preparation of favipiravir and its intermediates thereof
CN111704582B (zh) * 2020-06-23 2021-06-11 杭州煌森生物科技有限公司 一种法匹拉韦及其衍生物的制备方法
KR20230034848A (ko) * 2020-07-06 2023-03-10 옵티머스 드럭스 (피) 엘티디 파비피라비르의 합성
CN114656412A (zh) * 2020-12-22 2022-06-24 山东特珐曼药业有限公司 一种法匹拉韦的合成方法
CN112552245B (zh) * 2020-12-29 2022-08-02 苏州正济药业有限公司 法匹拉韦的合成方法
CN112851589B (zh) * 2021-01-25 2022-10-11 山东邹平大展新材料有限公司 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法
EP4452220A1 (en) 2021-12-23 2024-10-30 Subintro Limited Novel antiviral compositions comprising oleic acid
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法
CN120607562B (zh) * 2025-08-12 2025-10-10 南京艾镁特生物科技有限公司 一种苯甲酰基修饰核苷的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002125A1 (fr) * 1988-08-22 1990-03-08 Idemitsu Kosan Co. Ltd. Derives d'oxyrane et herbicides les contenant en tant qu'ingredients actifs
DE59209008D1 (de) * 1991-08-17 1997-12-11 Hoechst Ag 2-Fluorpyrazine, Verfahren zu ihrer Herstellung und ihre Verwendung in flüssigkristallinen Mischungen
ES2296399T3 (es) * 1998-08-20 2008-04-16 Toyama Chemical Co., Ltd. Derivados de la carboxamida heterociclica nitrogenada o una sal del mismo como agentes antivirales.

Also Published As

Publication number Publication date
CA2398620A1 (en) 2001-08-23
BRPI0108374B8 (pt) 2021-05-25
EP1256588A4 (en) 2003-03-26
DE60108724D1 (de) 2005-03-10
DE60108724T2 (de) 2005-06-23
BRPI0116967A2 (pt) 2009-07-14
MXPA02007890A (es) 2002-10-31
US6800629B2 (en) 2004-10-05
KR20030032918A (ko) 2003-04-26
ES2237550T3 (es) 2005-08-01
AU2001232287A1 (en) 2001-08-27
PT1256588E (pt) 2005-05-31
KR20030034120A (ko) 2003-05-01
WO2001060834A1 (en) 2001-08-23
BRPI0108374B1 (pt) 2017-10-10
EP1295890B1 (en) 2005-04-27
US20030130213A1 (en) 2003-07-10
KR20030048108A (ko) 2003-06-18
BRPI0116967B1 (pt) 2018-05-22
CA2398620C (en) 2009-06-23
ATE294185T1 (de) 2005-05-15
CN1239511C (zh) 2006-02-01
EP1295890A1 (en) 2003-03-26
EP1256588A1 (en) 2002-11-13
EP1256588B1 (en) 2005-02-02
ES2240645T3 (es) 2005-10-16
DE60110415T2 (de) 2005-09-29
CN1418220A (zh) 2003-05-14
JP5038345B2 (ja) 2012-10-03
KR100589935B1 (ko) 2006-06-15
ATE288443T1 (de) 2005-02-15
JP4379767B2 (ja) 2009-12-09
JP2009161553A (ja) 2009-07-23
BRPI0116967B8 (pt) 2021-05-25
DK1295890T3 (da) 2005-05-17
BR0108374A (pt) 2003-03-18
DE60110415D1 (de) 2005-06-02
KR100604955B1 (ko) 2006-07-26

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