PT1288203E - Nitronas ciclicas e composicoes farmaceuticas que as contem - Google Patents
Nitronas ciclicas e composicoes farmaceuticas que as contemInfo
- Publication number
- PT1288203E PT1288203E PT02024174T PT02024174T PT1288203E PT 1288203 E PT1288203 E PT 1288203E PT 02024174 T PT02024174 T PT 02024174T PT 02024174 T PT02024174 T PT 02024174T PT 1288203 E PT1288203 E PT 1288203E
- Authority
- PT
- Portugal
- Prior art keywords
- contain
- pharmaceutical compositions
- cyclic nitrones
- nitrones
- cyclic
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US355195P | 1995-09-11 | 1995-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1288203E true PT1288203E (pt) | 2005-08-31 |
Family
ID=21706397
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02024174T PT1288203E (pt) | 1995-09-11 | 1996-08-15 | Nitronas ciclicas e composicoes farmaceuticas que as contem |
| PT96928900T PT863878E (pt) | 1995-09-11 | 1996-08-15 | Nitronas ciclicas e composicoes farmaceuticas que as contem |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96928900T PT863878E (pt) | 1995-09-11 | 1996-08-15 | Nitronas ciclicas e composicoes farmaceuticas que as contem |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5962469A (pt) |
| EP (1) | EP0863878B1 (pt) |
| JP (1) | JPH11512427A (pt) |
| KR (1) | KR100512675B1 (pt) |
| CN (3) | CN1250528C (pt) |
| AR (1) | AR004950A1 (pt) |
| AT (2) | ATE293604T1 (pt) |
| AU (1) | AU701989B2 (pt) |
| CA (1) | CA2231812C (pt) |
| DE (2) | DE69625701T2 (pt) |
| DK (2) | DK0863878T3 (pt) |
| ES (2) | ES2239194T3 (pt) |
| HU (1) | HUP9803028A3 (pt) |
| IL (1) | IL123345A (pt) |
| MX (1) | MX9801892A (pt) |
| NO (1) | NO311357B1 (pt) |
| NZ (1) | NZ316288A (pt) |
| PT (2) | PT1288203E (pt) |
| TW (1) | TW337520B (pt) |
| WO (1) | WO1997010218A1 (pt) |
| ZA (1) | ZA967514B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69904018D1 (en) * | 1998-01-16 | 2003-01-02 | Centaur Pharmaceuticals Inc | Thiophennitronderivate |
| WO2000043397A1 (en) * | 1999-01-19 | 2000-07-27 | Neurosearch A/S | Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases |
| CN100513395C (zh) * | 2006-04-17 | 2009-07-15 | 中国科学院化学研究所 | 一种制备多羟基环状硝酮的方法 |
| CN101565453B (zh) * | 2008-04-22 | 2011-12-21 | 中国科学院化学研究所 | 具有捕获自由基功能的硝酮类化合物及其制备方法与应用 |
| ES2395803B1 (es) * | 2011-08-01 | 2013-12-19 | Consejo Superior De Investigaciones Científicas (Csic) - 80% | Quinolilnitronas |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| US10660851B2 (en) | 2015-01-02 | 2020-05-26 | Rxos Medical | Polyfunctional radical scavenger hydrogel formulation |
| CN108774274B (zh) * | 2015-03-06 | 2020-11-03 | 北京大学 | 唾液酸甲酯甲苷衍生物及其合成方法和应用 |
| JP7033081B2 (ja) * | 2016-02-08 | 2022-03-09 | ルナフォア・テクノロジーズ・エスアー | 試料サイクル多重化及びインサイツイメージングの方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US35112A (en) * | 1862-04-29 | Improvement in head-rests for car-seats | ||
| US3044930A (en) * | 1960-12-08 | 1962-07-17 | Phillips Petroleum Co | N-oxides of heterocyclic nitrogen compounds as bird and rodent repellents |
| US3796715A (en) * | 1967-08-30 | 1974-03-12 | Hoffmann La Roche | 8-alkoxy-3,4-dihydroisoquinolines |
| US4117144A (en) * | 1971-09-16 | 1978-09-26 | Ab Kabi | Derivatives of substituted isoindolines with effect on the central nervous system |
| SE368009B (pt) * | 1971-09-16 | 1974-06-17 | Kabi Ab | |
| US4123543A (en) * | 1971-09-16 | 1978-10-31 | Ab Kabi | Derivatives of substituted indoline lactans with effect on the central nervous system |
| JPS6363851A (ja) * | 1986-09-05 | 1988-03-22 | 孫七瓦工業株式会社 | 瓦の葺設方法 |
| DK0496796T3 (da) * | 1989-10-17 | 1994-10-03 | Oklahoma Med Res Found | Fremgangsmåde og præparater til inhibering af sygdomme i forbindelse med oxidativ beskadigelse |
| US5025032A (en) | 1989-10-17 | 1991-06-18 | Oklahoma Medical Research Foundation | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
| CA2111836C (en) * | 1991-06-18 | 2006-08-29 | John M. Carney | Spin-trapping pharmaceutical compositions and methods for use thereof |
| IL103111A (en) * | 1991-09-12 | 1996-07-23 | Merrell Dow Pharma | Cyclic nitrones a process for their production and pharmaceutical compositions containing them |
| US5292746A (en) * | 1991-09-12 | 1994-03-08 | Merrell Dow Pharmaceuticals Inc. | Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock |
| US5405967A (en) * | 1993-10-22 | 1995-04-11 | Oklahoma Medical Research Foundation | Spin-trap molecules 2-trifluoromethyl- of 5,5-dimethyl-1-dyrroline-N-oxide |
| US5455272A (en) * | 1993-10-22 | 1995-10-03 | Oklahoma Medical Research Foundation | Spin trap nitronyl hindered phenols |
| EP0675892A1 (en) * | 1993-10-25 | 1995-10-11 | Oklahoma Medical Research Foundation | Novel phosphorus-containing spin-trap compositions |
| US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
| US5472983A (en) * | 1994-04-14 | 1995-12-05 | Centaur Pharmaceuticals, Inc. | Benzamide-containing pharmaceutical compositions |
-
1996
- 1996-08-15 CN CNB96196877XA patent/CN1250528C/zh not_active Expired - Fee Related
- 1996-08-15 IL IL12334596A patent/IL123345A/xx not_active IP Right Cessation
- 1996-08-15 HU HU9803028A patent/HUP9803028A3/hu unknown
- 1996-08-15 KR KR1019980701806A patent/KR100512675B1/ko not_active Expired - Fee Related
- 1996-08-15 AT AT02024174T patent/ATE293604T1/de not_active IP Right Cessation
- 1996-08-15 DE DE69625701T patent/DE69625701T2/de not_active Expired - Fee Related
- 1996-08-15 MX MX9801892A patent/MX9801892A/es not_active IP Right Cessation
- 1996-08-15 EP EP96928900A patent/EP0863878B1/en not_active Expired - Lifetime
- 1996-08-15 NZ NZ316288A patent/NZ316288A/xx unknown
- 1996-08-15 PT PT02024174T patent/PT1288203E/pt unknown
- 1996-08-15 AT AT96928900T patent/ATE230731T1/de not_active IP Right Cessation
- 1996-08-15 ES ES02024174T patent/ES2239194T3/es not_active Expired - Lifetime
- 1996-08-15 DE DE69634647T patent/DE69634647T2/de not_active Expired - Fee Related
- 1996-08-15 PT PT96928900T patent/PT863878E/pt unknown
- 1996-08-15 CN CNA200310104608A patent/CN1500787A/zh not_active Withdrawn
- 1996-08-15 DK DK96928900T patent/DK0863878T3/da active
- 1996-08-15 CN CNA200310104609A patent/CN1500779A/zh active Pending
- 1996-08-15 AU AU68486/96A patent/AU701989B2/en not_active Ceased
- 1996-08-15 DK DK02024174T patent/DK1288203T3/da active
- 1996-08-15 JP JP9511955A patent/JPH11512427A/ja not_active Ceased
- 1996-08-15 ES ES96928900T patent/ES2185797T3/es not_active Expired - Lifetime
- 1996-08-15 WO PCT/US1996/013312 patent/WO1997010218A1/en not_active Ceased
- 1996-08-15 CA CA002231812A patent/CA2231812C/en not_active Expired - Fee Related
- 1996-09-05 ZA ZA967514A patent/ZA967514B/xx unknown
- 1996-09-06 TW TW085110921A patent/TW337520B/zh active
- 1996-09-09 AR ARP960104278A patent/AR004950A1/es not_active Application Discontinuation
-
1997
- 1997-11-26 US US08/978,971 patent/US5962469A/en not_active Expired - Fee Related
-
1998
- 1998-03-10 NO NO19981054A patent/NO311357B1/no unknown
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