PT1023291E - Derivados de dipiridoimidazole uteis no tratamento de desordens do sistema nervoso central - Google Patents
Derivados de dipiridoimidazole uteis no tratamento de desordens do sistema nervoso centralInfo
- Publication number
- PT1023291E PT1023291E PT98953243T PT98953243T PT1023291E PT 1023291 E PT1023291 E PT 1023291E PT 98953243 T PT98953243 T PT 98953243T PT 98953243 T PT98953243 T PT 98953243T PT 1023291 E PT1023291 E PT 1023291E
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- dipiridoimidazole
- disorders
- treatment
- nervous system
- Prior art date
Links
- 210000003169 central nervous system Anatomy 0.000 title 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6124897P | 1997-10-07 | 1997-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1023291E true PT1023291E (pt) | 2004-09-30 |
Family
ID=22034585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98953243T PT1023291E (pt) | 1997-10-07 | 1998-10-05 | Derivados de dipiridoimidazole uteis no tratamento de desordens do sistema nervoso central |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5968946A (pt) |
| EP (1) | EP1023291B1 (pt) |
| JP (1) | JP2001519351A (pt) |
| AT (1) | ATE267828T1 (pt) |
| AU (1) | AU1066499A (pt) |
| CA (1) | CA2305342A1 (pt) |
| DE (1) | DE69824195T2 (pt) |
| DK (1) | DK1023291T3 (pt) |
| ES (1) | ES2221996T3 (pt) |
| PT (1) | PT1023291E (pt) |
| WO (1) | WO1999018105A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358946B1 (en) | 1999-08-02 | 2002-03-19 | Ortho-Mcneil Pharmaceutical, Inc. | C-6 ring-substituted pyrido[1,2-a]benzimidazole derivatives useful in treating central nervous system disorders |
| AU2001264932A1 (en) | 2000-05-26 | 2001-12-11 | Neurogen Corporation | Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands |
| WO2005032484A2 (en) | 2003-10-03 | 2005-04-14 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| TW200526631A (en) * | 2003-10-07 | 2005-08-16 | Renovis Inc | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| US7888349B2 (en) | 2003-12-29 | 2011-02-15 | 3M Innovative Properties Company | Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds |
| WO2006084251A2 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
| US7576099B2 (en) * | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| JP2008531690A (ja) * | 2005-02-28 | 2008-08-14 | レノビス， インコーポレイテッド | イオンチャネルリガンドとしてのアミド誘導体並びにそれを使用する医薬組成物及び方法 |
| US8093265B2 (en) * | 2007-03-09 | 2012-01-10 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| EP3553051A4 (en) | 2016-12-06 | 2020-04-22 | Nippon Kayaku Kabushiki Kaisha | METHOD FOR PRODUCING 3- (PYRIDYL-2-AMINO) PROPIONITRILE AND ANALOGUE THEREOF |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE197455T1 (de) * | 1992-08-19 | 2000-11-11 | Mcneilab Inc | 3-oxo-pyrido (1,2-a) benzimidazol-4-carboxyl und 4-oxo-azepino (1,2-a) benzimidazol-5-carboxyl derivate geeignet für die behandlung von zentralnervensystemerkrankungen |
| JP2001501949A (ja) * | 1996-10-07 | 2001-02-13 | オーソ―マクニール・フアーマシユーチカル・インコーポレーテツド | 中枢神経系疾患を処置することに有用な５―ヘテロ原子を含有するアルキル置換された―３―オキソ―ピリド（１，２―ａ）ベンゾイミダゾール―４―カルボキサミド誘導体 |
-
1998
- 1998-10-05 AT AT98953243T patent/ATE267828T1/de not_active IP Right Cessation
- 1998-10-05 AU AU10664/99A patent/AU1066499A/en not_active Abandoned
- 1998-10-05 JP JP2000514916A patent/JP2001519351A/ja active Pending
- 1998-10-05 CA CA002305342A patent/CA2305342A1/en not_active Abandoned
- 1998-10-05 PT PT98953243T patent/PT1023291E/pt unknown
- 1998-10-05 US US09/166,327 patent/US5968946A/en not_active Expired - Lifetime
- 1998-10-05 DE DE69824195T patent/DE69824195T2/de not_active Expired - Fee Related
- 1998-10-05 ES ES98953243T patent/ES2221996T3/es not_active Expired - Lifetime
- 1998-10-05 WO PCT/US1998/020802 patent/WO1999018105A1/en not_active Ceased
- 1998-10-05 DK DK98953243T patent/DK1023291T3/da active
- 1998-10-05 EP EP98953243A patent/EP1023291B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001519351A (ja) | 2001-10-23 |
| EP1023291A1 (en) | 2000-08-02 |
| CA2305342A1 (en) | 1999-04-15 |
| ATE267828T1 (de) | 2004-06-15 |
| AU1066499A (en) | 1999-04-27 |
| DK1023291T3 (da) | 2004-10-04 |
| ES2221996T3 (es) | 2005-01-16 |
| US5968946A (en) | 1999-10-19 |
| EP1023291B1 (en) | 2004-05-26 |
| DE69824195D1 (de) | 2004-07-01 |
| DE69824195T2 (de) | 2005-06-23 |
| WO1999018105A8 (en) | 1999-06-10 |
| WO1999018105A1 (en) | 1999-04-15 |
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