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PL66636B1 - - Google Patents

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Publication number
PL66636B1
PL66636B1 PL131937A PL13193769A PL66636B1 PL 66636 B1 PL66636 B1 PL 66636B1 PL 131937 A PL131937 A PL 131937A PL 13193769 A PL13193769 A PL 13193769A PL 66636 B1 PL66636 B1 PL 66636B1
Authority
PL
Poland
Prior art keywords
methylpropyl
dimethylamino
methoxy
acid
phenothiazines
Prior art date
Application number
PL131937A
Other languages
Polish (pl)
Inventor
Wrotek Jerzy
Gogolimska Barbara
AlicjaRaczka
Piechaczek Janina
Cieslik Wanda
Original Assignee
Instytut Farmaceutyczny
Filing date
Publication date
Application filed by Instytut Farmaceutyczny filed Critical Instytut Farmaceutyczny
Publication of PL66636B1 publication Critical patent/PL66636B1/pl

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Claims (3)

Zastrzezenia patentowe 40 1. Sposób otrzymywania (+)- i (—)-2-metoksy-10- - (3 -dwumetyloamino - 2 --metylopropylo) - fenotiazyn ewentualnie w postaci ich kwasnych maleinianów, znamienny tym, ze racemiczna 2-metoksy-10-(3- 45 - dwumetyloamino - 2 - metylopropylo) - fenotiazyne poddaje sie dzialaniu monoamidu kwasu dwuacety- lo-(+)-winowego w srodowisku rozpuszczalnika/ w którym róznica rozpuszczalnosci powstajacych soli diastereoizomerycznych jest dostatecznie duza, 50 takiego jak nizszy alkohol alifatyczny, roztwór po¬ reakcyjny poddaje sie krystalizacji, a z rozdzielo¬ nych soli diastereoizomerycznych uwalnia sie (+)- i (—)-2-metoksy-10-(3-dwumetyloamino-2-metylo- propylo)-fenotiazyny, które ewentualnie w znany 55 sposób przeprowadza sie w kwasne maleiniany. Claims 40 1. A method for the preparation of (+) - and (-) - 2-methoxy-10- - (3-dimethylamino-2-methylpropyl) - phenothiazines, optionally in the form of their acid maleates, characterized by the racemic 2-methoxy -10- (3- 45 - dimethylamino - 2 - methylpropyl) - phenothiazines are subjected to the action of diacetyl - (+) - tartaric acid monoamide in a solvent environment / in which the difference in solubility of the resulting diastereomeric salts is sufficiently large, 50 such as lower alcohol the aliphatic reaction solution is crystallized, and the (+) - and (-) - 2-methoxy-10- (3-dimethylamino-2-methylpropyl) phenothiazines are released from the separated diastereomeric salts. the known process is converted into acid maleates. 2. Sposób wedlug zastrz. 1, znamienny tym, ze jako alkohol alifatyczny stosuje sie izopropanol. 2. The method according to claim The process of claim 1, wherein the aliphatic alcohol is isopropanol. 3. Sposób wedlug zastrz. 1, znamienny tym, ze z soli diastereoizomerycznych uwalnia sie (+)- 60 i (—)-2-metoksy-10-(3-dwumetyloamino-2-metylo- propylo)-fenotiazyny przez zadawanie roztworów tych soli kwasem nieorganicznym, zwlaszcza kwa¬ sem solnym, oddzielenie wytraconego monoamidu kwasu dwuacetylo-{+)-winowego i zalkalizowariie w powstalego roztworu. 4.8.72 — 105egz. *' ' Cena zl 10.— PL3. The method according to p. A process as claimed in claim 1, characterized in that (+) - 60 and (-) - 2-methoxy-10- (3-dimethylamino-2-methylpropyl) -phenothiazine are released from the diastereomeric salts by treating solutions of these salts with an inorganic acid, especially acid With a salt solution, separation of the precipitated diacetyl - {+) - tartaric acid monoamide and basification of the resulting solution. 4.8.72 - 105 ex. * '' Price PLN 10.- PL
PL131937A 1969-02-24 PL66636B1 (en)

Publications (1)

Publication Number Publication Date
PL66636B1 true PL66636B1 (en) 1972-08-31

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