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PL444001A1 - Computer-implemented method and related computer program products for determining biological age and predicting health status of an individual using information about epigenetic modifications - Google Patents

Computer-implemented method and related computer program products for determining biological age and predicting health status of an individual using information about epigenetic modifications

Info

Publication number
PL444001A1
PL444001A1 PL444001A PL44400123A PL444001A1 PL 444001 A1 PL444001 A1 PL 444001A1 PL 444001 A PL444001 A PL 444001A PL 44400123 A PL44400123 A PL 44400123A PL 444001 A1 PL444001 A1 PL 444001A1
Authority
PL
Poland
Prior art keywords
age
computer
implemented method
biological age
cpg
Prior art date
Application number
PL444001A
Other languages
Polish (pl)
Inventor
Tomasz WOJDACZ
Jan Bińkowski
Olga Taryma-Leśniak
Original Assignee
Pomorski Uniwersytet Medyczny W Szczecinie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pomorski Uniwersytet Medyczny W Szczecinie filed Critical Pomorski Uniwersytet Medyczny W Szczecinie
Priority to PL444001A priority Critical patent/PL444001A1/en
Priority to EP24712954.7A priority patent/EP4677603A1/en
Priority to PCT/IB2024/052219 priority patent/WO2024184854A1/en
Publication of PL444001A1 publication Critical patent/PL444001A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Zgłoszenie dotyczy sposobu realizowanego komputerowo do określania wieku biologicznego osobnika, obejmującego: a) dostarczanie mapy metylacji powiązanej z wiekiem; b) dostarczanie modelu regresji wieku biologicznego na podstawie zidentyfikowanych wielu cech opartych na sąsiadujących ze sobą parach CpG, wskazujących na wiek metrykalny; c) generowanie profilu metylacji powiązanego z wiekiem opartego na parach CpG, dla komórki lub tkanki od osobnika zawartej w badanej próbce, przy czym wspomniany profil metylacji oparty na parach CpG zawiera koordynaty genomowe dla sąsiadujących ze sobą miejsc CpG w każdej parze skorelowane z wiekiem metrykalnym i przy czym pojedyncza wartość liczbowa stanowi skompresowaną informację o poziomie metylacji związaną ze wspomnianą parą skorelowaną z wiekiem metrykalnym; d) określanie wieku biologicznego osobnika przez analizowanie wspomnianego profilu metylacji opartego na parach CpG dla wspomnianej badanej próbki z zastosowaniem modelu regresji wieku biologicznego. Niniejszym ujawniono również sposób realizowany komputerowo do przewidywania stanu zdrowia osobnika oraz materialny odczytywalny komputerowo nośnik zawierający odczytywalny komputerowo kod.The application relates to a computer-implemented method for determining the biological age of a subject, comprising: a) providing an age-related methylation map; b) providing a biological age regression model based on an identified plurality of features based on contiguous CpG pairs indicative of chronological age; c) generating an age-related methylation profile based on CpG pairs for a cell or tissue from the subject contained in a test sample, said CpG pair-based methylation profile comprising genomic coordinates for contiguous CpG sites in each pair correlated with chronological age, and wherein the single numerical value is compressed methylation level information associated with said pair correlated with chronological age; d) determining the biological age of the subject by analyzing said CpG pair-based methylation profile for said test sample using a biological age regression model. Also disclosed herein is a computer-implemented method for predicting the health of a subject, and a tangible computer-readable medium comprising computer-readable code.

PL444001A 2023-03-07 2023-03-07 Computer-implemented method and related computer program products for determining biological age and predicting health status of an individual using information about epigenetic modifications PL444001A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL444001A PL444001A1 (en) 2023-03-07 2023-03-07 Computer-implemented method and related computer program products for determining biological age and predicting health status of an individual using information about epigenetic modifications
EP24712954.7A EP4677603A1 (en) 2023-03-07 2024-03-07 Methods, systems and assosiated computer program products for discriminating type of biological sample of an organism using epigenetic modification information
PCT/IB2024/052219 WO2024184854A1 (en) 2023-03-07 2024-03-07 Methods, systems and assosiated computer program products for discriminating type of biological sample of an organism using epigenetic modification information

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL444001A PL444001A1 (en) 2023-03-07 2023-03-07 Computer-implemented method and related computer program products for determining biological age and predicting health status of an individual using information about epigenetic modifications

Publications (1)

Publication Number Publication Date
PL444001A1 true PL444001A1 (en) 2024-09-09

Family

ID=92676890

Family Applications (1)

Application Number Title Priority Date Filing Date
PL444001A PL444001A1 (en) 2023-03-07 2023-03-07 Computer-implemented method and related computer program products for determining biological age and predicting health status of an individual using information about epigenetic modifications

Country Status (1)

Country Link
PL (1) PL444001A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016115530A1 (en) * 2015-01-18 2016-07-21 The Regents Of The University Of California Method and system for determining cancer status
CN113528648A (en) * 2021-07-22 2021-10-22 深圳市精笃健康科技有限公司 Method for judging aging degree based on gene mutation and DNA methylation characteristics
KR20220008133A (en) * 2020-07-13 2022-01-20 대한민국(관리부서: 행정안전부 국립과학수사연구원장) Method for bone age predeiction and marker thereof
CN114400050A (en) * 2022-03-14 2022-04-26 中南大学 DMR set identification result evaluation method, evaluation system and selection method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016115530A1 (en) * 2015-01-18 2016-07-21 The Regents Of The University Of California Method and system for determining cancer status
KR20220008133A (en) * 2020-07-13 2022-01-20 대한민국(관리부서: 행정안전부 국립과학수사연구원장) Method for bone age predeiction and marker thereof
CN113528648A (en) * 2021-07-22 2021-10-22 深圳市精笃健康科技有限公司 Method for judging aging degree based on gene mutation and DNA methylation characteristics
CN114400050A (en) * 2022-03-14 2022-04-26 中南大学 DMR set identification result evaluation method, evaluation system and selection method

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