PH12017500517B1 - Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors - Google Patents
Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitorsInfo
- Publication number
- PH12017500517B1 PH12017500517B1 PH1/2017/500517A PH12017500517A PH12017500517B1 PH 12017500517 B1 PH12017500517 B1 PH 12017500517B1 PH 12017500517 A PH12017500517 A PH 12017500517A PH 12017500517 B1 PH12017500517 B1 PH 12017500517B1
- Authority
- PH
- Philippines
- Prior art keywords
- mutant
- pyridin
- isocitrate dehydrogenase
- dehydrogenase inhibitors
- quinolinone derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- ASHZGMCLOXNDFT-UHFFFAOYSA-N 1H-pyridin-2-one 1H-quinolin-2-one Chemical class O=C1C=CC=CN1.C1=CC=C2NC(=O)C=CC2=C1 ASHZGMCLOXNDFT-UHFFFAOYSA-N 0.000 title 1
- 101710088194 Dehydrogenase Proteins 0.000 title 1
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 abstract 1
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 230000003538 neomorphic effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462053006P | 2014-09-19 | 2014-09-19 | |
| US201562128089P | 2015-03-04 | 2015-03-04 | |
| US201562150812P | 2015-04-21 | 2015-04-21 | |
| PCT/US2015/051055 WO2016044789A1 (en) | 2014-09-19 | 2015-09-18 | Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12017500517A1 PH12017500517A1 (en) | 2017-08-07 |
| PH12017500517B1 true PH12017500517B1 (en) | 2022-08-03 |
Family
ID=54291606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2017/500517A PH12017500517B1 (en) | 2014-09-19 | 2015-09-18 | Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
Country Status (37)
| Country | Link |
|---|---|
| US (8) | US9834539B2 (en) |
| EP (4) | EP4257131A3 (en) |
| JP (1) | JP6648115B2 (en) |
| KR (1) | KR102209667B1 (en) |
| CN (3) | CN107001328B (en) |
| AU (3) | AU2015317329B2 (en) |
| BR (1) | BR112017005238B1 (en) |
| CA (1) | CA2961817C (en) |
| CL (1) | CL2017000658A1 (en) |
| CO (1) | CO2017003241A2 (en) |
| CY (2) | CY1121149T1 (en) |
| DK (2) | DK3194376T3 (en) |
| EA (1) | EA034336B1 (en) |
| EC (1) | ECSP17022933A (en) |
| ES (3) | ES2953347T3 (en) |
| FI (1) | FI3733662T3 (en) |
| HR (1) | HRP20200666T1 (en) |
| HU (2) | HUE041460T2 (en) |
| IL (3) | IL292608B2 (en) |
| LT (2) | LT3447050T (en) |
| MA (2) | MA53352A (en) |
| ME (1) | ME03776B (en) |
| MX (2) | MX385512B (en) |
| MY (2) | MY176250A (en) |
| NZ (1) | NZ730373A (en) |
| PE (1) | PE20171056A1 (en) |
| PH (1) | PH12017500517B1 (en) |
| PL (3) | PL3447050T3 (en) |
| PT (3) | PT3447050T (en) |
| RS (2) | RS58184B1 (en) |
| SA (1) | SA517381129B1 (en) |
| SG (1) | SG11201702194SA (en) |
| SI (2) | SI3194376T1 (en) |
| SM (2) | SMT202000212T1 (en) |
| TW (1) | TWI686390B (en) |
| WO (1) | WO2016044789A1 (en) |
| ZA (3) | ZA201702127B (en) |
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| JP6067226B2 (en) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ， インコーポレイテッド | Methods and compositions for cell proliferation related diseases |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| SI3406609T1 (en) | 2014-02-06 | 2024-10-30 | Nxera Pharma Uk Limited | Bicyclic aza compounds as muscarinic receptor agonists |
| ES2953347T3 (en) | 2014-09-19 | 2023-11-10 | Forma Therapeutics Inc | Pyridin-2(1H)-one quinolinone derivatives as inhibitors of mutant isocitrate dehydrogenase |
| WO2016044787A1 (en) | 2014-09-19 | 2016-03-24 | Forma Therapeutics, Inc. | Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| JP6664385B2 (en) | 2014-09-19 | 2020-03-13 | バイエル ファーマ アクチエンゲゼルシャフト | Benzyl-substituted indazoles as Bub1 inhibitors |
| JP6648116B2 (en) * | 2014-09-19 | 2020-02-14 | フォーマ セラピューティクス，インコーポレイテッド | Quinolinone pyrimidine compositions as mutant isocitrate dehydrogenase inhibitors |
| WO2016044782A1 (en) | 2014-09-19 | 2016-03-24 | Forma Therapeutics, Inc. | Phenyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| JP6901394B2 (en) | 2014-12-22 | 2021-07-14 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Mutant IDH1 inhibitor useful for cancer treatment |
| US9624216B2 (en) | 2015-04-21 | 2017-04-18 | Forma Therapeutics, Inc. | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors |
| US10294206B2 (en) | 2015-04-21 | 2019-05-21 | Forma Tm2, Inc. | Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| WO2018202524A1 (en) | 2017-05-04 | 2018-11-08 | Bayer Cropscience Aktiengesellschaft | 2-{[2-(phenyloxymethyl)pyridin-5-yl]oxy}-ethanamin-derivatives and related compounds as pest-control agents e.g. for the protection of plants |
| US11013734B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation |
| US11311527B2 (en) | 2018-05-16 | 2022-04-26 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) |
| WO2019222551A1 (en) | 2018-05-16 | 2019-11-21 | Forma Therapeutics, Inc. | Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile |
| US11013733B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1) |
| DK3720442T3 (en) | 2018-05-16 | 2023-03-27 | Forma Therapeutics Inc | INHIBITION OF MUTANT IDH-1 |
| US11576906B2 (en) | 2018-05-16 | 2023-02-14 | Forma Therapeutics, Inc. | Inhibiting mutant IDH-1 |
| WO2020232381A1 (en) | 2019-05-16 | 2020-11-19 | Forma Therapeutics, Inc. | INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1) |
| TW202104207A (en) * | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | Dihydroorotate dehydrogenase inhibitors |
| US11566013B1 (en) * | 2019-11-20 | 2023-01-31 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1) |
| CN112341389B (en) * | 2020-10-27 | 2022-07-29 | 浙江工业大学 | Nitrogen-containing aromatic heterocycle substituted quinoline formamide derivative and application thereof |
| CN112321571B (en) * | 2020-10-27 | 2022-06-03 | 浙江工业大学 | 2-Furan-quinoline-4-carboxamide compounds and their applications |
| CN115850240B (en) * | 2022-12-28 | 2023-09-19 | 北京康立生医药技术开发有限公司 | Synthesis method of medicine ao Lu Taxi Ni for treating acute myelogenous leukemia |
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| ES2953347T3 (en) * | 2014-09-19 | 2023-11-10 | Forma Therapeutics Inc | Pyridin-2(1H)-one quinolinone derivatives as inhibitors of mutant isocitrate dehydrogenase |
| WO2016044782A1 (en) | 2014-09-19 | 2016-03-24 | Forma Therapeutics, Inc. | Phenyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| JP6901394B2 (en) | 2014-12-22 | 2021-07-14 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Mutant IDH1 inhibitor useful for cancer treatment |
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2015
- 2015-09-18 ES ES20157755T patent/ES2953347T3/en active Active
- 2015-09-18 LT LTEP18198969.0T patent/LT3447050T/en unknown
- 2015-09-18 FI FIEP20157755.8T patent/FI3733662T3/en active
- 2015-09-18 EP EP23176702.1A patent/EP4257131A3/en active Pending
- 2015-09-18 DK DK15778433.1T patent/DK3194376T3/en active
- 2015-09-18 PL PL18198969T patent/PL3447050T3/en unknown
- 2015-09-18 PH PH1/2017/500517A patent/PH12017500517B1/en unknown
- 2015-09-18 US US14/858,167 patent/US9834539B2/en active Active
- 2015-09-18 EA EA201790657A patent/EA034336B1/en unknown
- 2015-09-18 JP JP2017515059A patent/JP6648115B2/en active Active
- 2015-09-18 PL PL15778433T patent/PL3194376T3/en unknown
- 2015-09-18 HU HUE15778433A patent/HUE041460T2/en unknown
- 2015-09-18 NZ NZ73037315A patent/NZ730373A/en unknown
- 2015-09-18 PT PT181989690T patent/PT3447050T/en unknown
- 2015-09-18 PL PL20157755.8T patent/PL3733662T3/en unknown
- 2015-09-18 PE PE2017000471A patent/PE20171056A1/en unknown
- 2015-09-18 CN CN201580050441.5A patent/CN107001328B/en active Active
- 2015-09-18 EP EP18198969.0A patent/EP3447050B1/en active Active
- 2015-09-18 AU AU2015317329A patent/AU2015317329B2/en active Active
- 2015-09-18 CA CA2961817A patent/CA2961817C/en active Active
- 2015-09-18 RS RS20181586A patent/RS58184B1/en unknown
- 2015-09-18 CN CN202311265288.0A patent/CN117695280A/en active Pending
- 2015-09-18 BR BR112017005238-5A patent/BR112017005238B1/en active IP Right Grant
- 2015-09-18 EP EP20157755.8A patent/EP3733662B1/en active Active
- 2015-09-18 PT PT15778433T patent/PT3194376T/en unknown
- 2015-09-18 SI SI201530537T patent/SI3194376T1/en unknown
- 2015-09-18 SI SI201531117T patent/SI3447050T1/en unknown
- 2015-09-18 ES ES18198969T patent/ES2790640T3/en active Active
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- 2015-09-18 MY MYPI2020001463A patent/MY197533A/en unknown
- 2015-09-18 SG SG11201702194SA patent/SG11201702194SA/en unknown
- 2015-09-18 HU HUE20157755A patent/HUE062424T2/en unknown
- 2015-09-18 MA MA053352A patent/MA53352A/en unknown
- 2015-09-18 RS RS20200418A patent/RS60140B1/en unknown
- 2015-09-18 SM SM20190018T patent/SMT201900018T1/en unknown
- 2015-09-18 PT PT201577558T patent/PT3733662T/en unknown
- 2015-09-18 TW TW104131044A patent/TWI686390B/en active
- 2015-09-18 LT LTEP15778433.1T patent/LT3194376T/en unknown
- 2015-09-18 ME MEP-2020-78A patent/ME03776B/en unknown
- 2015-09-18 ES ES15778433T patent/ES2704897T3/en active Active
- 2015-09-18 WO PCT/US2015/051055 patent/WO2016044789A1/en not_active Ceased
- 2015-09-18 MX MX2017003404A patent/MX2017003404A/en active IP Right Grant
- 2015-09-18 EP EP15778433.1A patent/EP3194376B1/en active Active
- 2015-09-18 DK DK18198969.0T patent/DK3447050T3/en active
- 2015-09-18 IL IL292608A patent/IL292608B2/en unknown
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- 2015-09-18 CN CN202010391529.6A patent/CN111909130B/en active Active
- 2015-09-18 KR KR1020177010585A patent/KR102209667B1/en active Active
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2017
- 2017-03-07 US US15/452,256 patent/US20170174658A1/en not_active Abandoned
- 2017-03-14 IL IL251163A patent/IL251163B/en active IP Right Grant
- 2017-03-17 CL CL2017000658A patent/CL2017000658A1/en unknown
- 2017-03-19 SA SA517381129A patent/SA517381129B1/en unknown
- 2017-03-27 ZA ZA2017/02127A patent/ZA201702127B/en unknown
- 2017-04-03 CO CONC2017/0003241A patent/CO2017003241A2/en unknown
- 2017-04-13 EC ECIEPI201722933A patent/ECSP17022933A/en unknown
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2018
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2019
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2021
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2022
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