PE91998A1 - Metodo para la sintesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea - Google Patents
Metodo para la sintesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroideaInfo
- Publication number
- PE91998A1 PE91998A1 PE1997000645A PE00064597A PE91998A1 PE 91998 A1 PE91998 A1 PE 91998A1 PE 1997000645 A PE1997000645 A PE 1997000645A PE 00064597 A PE00064597 A PE 00064597A PE 91998 A1 PE91998 A1 PE 91998A1
- Authority
- PE
- Peru
- Prior art keywords
- terminal
- fragment
- parathyroid hormone
- precursor
- product
- Prior art date
Links
- 108090000445 Parathyroid hormone Proteins 0.000 title abstract 5
- 102000003982 Parathyroid hormone Human genes 0.000 title abstract 3
- 239000000199 parathyroid hormone Substances 0.000 title abstract 3
- 229960001319 parathyroid hormone Drugs 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 abstract 6
- 239000002243 precursor Substances 0.000 abstract 4
- 239000011347 resin Substances 0.000 abstract 4
- 229920005989 resin Polymers 0.000 abstract 4
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 abstract 3
- 102000043299 Parathyroid hormone-related Human genes 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 210000004898 n-terminal fragment Anatomy 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 101800001415 Bri23 peptide Proteins 0.000 abstract 1
- 101800000655 C-terminal peptide Proteins 0.000 abstract 1
- 102400000107 C-terminal peptide Human genes 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 241000520223 Helice Species 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical group CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 102100036893 Parathyroid hormone Human genes 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA LA SINTESIS DE UN POLIPEPTIDO ANALOGO A LA HORMONA PARATIROIDEA (PTH) O UN PEPTIDO RELACIONADO CON LA HORMONA PARATIROIDEA (PTHrP), QUE COMPRENDE: (a) LA SINTESIS INDEPENDIENTE DE LOS FRAGMENTOS PEPTIDICOS PRECURSORES DEL POLIPEPTIDO DESEADO SOBRE UN SOPORTE SOLIDO DE RESINA; (b) LA ESCISION DE TODOS LOS FRAGMENTOS PEPTIDICOS PRECURSORES EXCEPTO EL FRAGMENTO PEPTIDICO PRECURSOR C-TERMINAL DE SUS RESPECTIVOS SOPORTES DE RESINA; (c) LA CONDENSACION SECUENCIAL DE LOS FRAGMENTOS PEPTIDICOS PRECURSORES ESCINDIDOS AL FRAGMENTO PEPTIDICO C-TERMINAL UNIDO A LA RESINA PARA FORMAR EL PRODUCTO POLIPEPTIDICO DESEADO; (d) ELIMINACION DE LOS GRUPOS PROTECTORES DE LAS CADENAS LATERALES; (e) LA ESCISION DEL PRODUCTO POLIPEPTIDICO DEL SOPORTE DE RESINA; EN DONDE EL PRODUCTO POLIPEPTIDICO OBTENIDO SE PREPARA A PARTIR DE 3 FRAGMENTOS PRECURSORES: UN FRAGMENTO N-TERMINAL QUE POSEE GLICINA C-TERMINAL, UN FRAGMENTO MEDIO QUE POSEE LEUCINA C-TERMINAL Y UN FRAGMENTO C-TERMINAL QUE POSEE LEUCINA N-TERMINAL. LOS ANALOGOS PTH o PTHrP PRESENTAN UNA SECUENCIA DE HASTA 34 AMINOACIDOS, EN DONDE LA SECUENCIA AMINOACIDA QUE COMPRENDE DEL 22 AL 31 CONFORMAN UNA HELICE O ANFIPATICA, SIENDO UNA SECUENCIA PREFERIDA: "AVSEHQLLHDKGKSIQDLRRRELLEKLLEKLHTA-NH2"(SEQ. 7). ESTOS POLIPEPTIDOS SON UTILES EN EL TRATAMIENTO DE OSTEOPOROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2332296P | 1996-07-30 | 1996-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE91998A1 true PE91998A1 (es) | 1998-12-31 |
Family
ID=21814418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000645A PE91998A1 (es) | 1996-07-30 | 1997-07-21 | Metodo para la sintesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6849710B1 (es) |
| EP (1) | EP0822200B1 (es) |
| JP (1) | JP4229992B2 (es) |
| KR (1) | KR100518982B1 (es) |
| CN (1) | CN1293096C (es) |
| AR (2) | AR008094A1 (es) |
| AT (1) | ATE277080T1 (es) |
| AU (1) | AU731160B2 (es) |
| BR (1) | BR9704138A (es) |
| CA (1) | CA2206008C (es) |
| CO (1) | CO4650046A1 (es) |
| CZ (1) | CZ239697A3 (es) |
| DE (1) | DE69730787T2 (es) |
| DK (1) | DK0822200T3 (es) |
| ES (1) | ES2227639T3 (es) |
| HR (1) | HRP970416A2 (es) |
| HU (1) | HUP9701277A3 (es) |
| IL (1) | IL121391A0 (es) |
| MA (1) | MA24353A1 (es) |
| MX (1) | MX9705719A (es) |
| NO (1) | NO973482L (es) |
| NZ (1) | NZ328411A (es) |
| PE (1) | PE91998A1 (es) |
| PL (1) | PL321391A1 (es) |
| SG (1) | SG67408A1 (es) |
| TR (1) | TR199700714A2 (es) |
| TW (1) | TW505654B (es) |
| UY (1) | UY24651A1 (es) |
| YU (1) | YU32197A (es) |
| ZA (1) | ZA976555B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003059291A2 (en) * | 2002-01-10 | 2003-07-24 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
| US7378495B2 (en) * | 2002-10-21 | 2008-05-27 | Pevion Biotech, Ltd. | PTH-rP related peptide cancer therapeutics |
| CA2628945A1 (en) * | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| DK1979370T3 (da) * | 2006-01-17 | 2010-06-28 | Organon Nv | Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider |
| US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| LT2957278T (lt) | 2006-10-03 | 2017-09-11 | Radius Health, Inc. | Stabili kompozicija, apimanti pthrp ir jos panaudojimas |
| USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| US8563513B2 (en) | 2009-03-27 | 2013-10-22 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| JP2013512688A (ja) | 2009-12-07 | 2013-04-18 | ミシガン テクノロジカル ユニバーシティ | クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法 |
| CN102731643A (zh) * | 2012-06-26 | 2012-10-17 | 深圳翰宇药业股份有限公司 | 一种治疗骨质疏松多肽的制备方法 |
| CN102993293B (zh) * | 2012-12-05 | 2014-05-07 | 深圳翰宇药业股份有限公司 | 一种特立帕肽醋酸盐的纯化方法 |
| MX363522B (es) | 2013-03-21 | 2019-03-26 | Sanofi Aventis Deutschland | Síntesis de productos peptídicos que contienen hidantoína. |
| MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
| CA2943611A1 (en) | 2014-03-28 | 2015-10-01 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| CN104530198B (zh) * | 2014-12-09 | 2017-09-15 | 兰州大学 | 一种片段缩合制备醋酸去氨加压素的方法 |
| CA2984357A1 (en) | 2015-04-29 | 2016-11-03 | Radius Pharmaceuticals, Inc. | Methods for treating cancer |
| JP7481115B2 (ja) | 2017-01-05 | 2024-05-10 | ラジウス ファーマシューティカルズ，インコーポレイテッド | Ｒａｄ１９０１－２ｈｃｌの多形性形態 |
| US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
| WO2019175173A1 (en) * | 2018-03-12 | 2019-09-19 | Fresenius Kabi Ipsum S.R.L. | Process for the manufacture of pthrp analogue |
| IL279853B2 (en) | 2018-07-04 | 2025-01-01 | Radius Pharmaceuticals Inc | Polymorphic forms of RAD 1901-2HCL |
| CN111057139B (zh) * | 2018-10-17 | 2023-12-22 | 南京华威医药科技集团有限公司 | 一种制备特立帕肽的新工艺 |
| CN119390714A (zh) | 2019-02-12 | 2025-02-07 | 雷迪厄斯制药公司 | 方法和化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886132A (en) * | 1972-12-21 | 1975-05-27 | Us Health | Human parathyroid hormone |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| EP0539491A1 (en) * | 1990-07-13 | 1993-05-05 | The Regents Of The University Of California | PARATHYROID HORMONE ANALOGUES MODIFIED AT POSITIONS 3, 6 or 9 |
| GB9020544D0 (en) * | 1990-09-20 | 1990-10-31 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| WO1995002610A1 (en) * | 1993-07-13 | 1995-01-26 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| CO4410206A1 (es) * | 1994-07-28 | 1997-01-09 | Sandoz Ag | DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
-
1997
- 1997-07-10 TW TW086109753A patent/TW505654B/zh active
- 1997-07-18 CA CA002206008A patent/CA2206008C/en not_active Expired - Lifetime
- 1997-07-21 PE PE1997000645A patent/PE91998A1/es not_active Application Discontinuation
- 1997-07-23 ES ES97112595T patent/ES2227639T3/es not_active Expired - Lifetime
- 1997-07-23 DK DK97112595T patent/DK0822200T3/da active
- 1997-07-23 HU HU9701277A patent/HUP9701277A3/hu unknown
- 1997-07-23 DE DE69730787T patent/DE69730787T2/de not_active Expired - Lifetime
- 1997-07-23 AT AT97112595T patent/ATE277080T1/de active
- 1997-07-23 SG SG1997002618A patent/SG67408A1/en unknown
- 1997-07-23 ZA ZA9706555A patent/ZA976555B/xx unknown
- 1997-07-23 EP EP97112595A patent/EP0822200B1/en not_active Expired - Lifetime
- 1997-07-24 NZ NZ328411A patent/NZ328411A/xx unknown
- 1997-07-24 IL IL12139197A patent/IL121391A0/xx unknown
- 1997-07-24 JP JP19807297A patent/JP4229992B2/ja not_active Expired - Lifetime
- 1997-07-25 YU YU32197A patent/YU32197A/sh unknown
- 1997-07-25 HR HR60/023,322A patent/HRP970416A2/hr not_active Application Discontinuation
- 1997-07-28 CO CO97042932A patent/CO4650046A1/es unknown
- 1997-07-28 AR ARP970103413A patent/AR008094A1/es not_active Application Discontinuation
- 1997-07-28 CZ CZ972396A patent/CZ239697A3/cs unknown
- 1997-07-29 MA MA24742A patent/MA24353A1/fr unknown
- 1997-07-29 NO NO973482A patent/NO973482L/no not_active Application Discontinuation
- 1997-07-29 KR KR1019970035861A patent/KR100518982B1/ko not_active Expired - Lifetime
- 1997-07-29 PL PL97321391A patent/PL321391A1/xx unknown
- 1997-07-29 MX MX9705719A patent/MX9705719A/es active IP Right Grant
- 1997-07-29 AU AU32362/97A patent/AU731160B2/en not_active Ceased
- 1997-07-29 CN CNB971154686A patent/CN1293096C/zh not_active Expired - Lifetime
- 1997-07-29 UY UY24651A patent/UY24651A1/es not_active Application Discontinuation
- 1997-07-30 US US08/903,124 patent/US6849710B1/en not_active Expired - Lifetime
- 1997-07-30 TR TR97/00714A patent/TR199700714A2/xx unknown
- 1997-07-30 BR BR9704138A patent/BR9704138A/pt active Search and Examination
-
1999
- 1999-02-16 AR ARP990100625A patent/AR016981A2/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |