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PE84299A1 - PARTIALLY HYDROGENATED POLYCLIC COMPOUNDS - Google Patents

PARTIALLY HYDROGENATED POLYCLIC COMPOUNDS

Info

Publication number
PE84299A1
PE84299A1 PE00059998A PE00059998A PE84299A1 PE 84299 A1 PE84299 A1 PE 84299A1 PE 00059998 A PE00059998 A PE 00059998A PE 00059998 A PE00059998 A PE 00059998A PE 84299 A1 PE84299 A1 PE 84299A1
Authority
PE
Peru
Prior art keywords
ring
polyclic
compounds
partially hydrogenated
wavy lines
Prior art date
Application number
PE00059998A
Other languages
Spanish (es)
Inventor
Jurg Zimmermann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE84299A1 publication Critical patent/PE84299A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to a compound of formula (I), wherein R1, R2, R3, R4, R5, n, m, p, X and Z are as defined in the description; and either the two bonds characterised by wavy lines are absent in ring A and replaced by a total of 4 hydrogen atoms, and the two wavy lines in ring B each, together with the respective parallel bond, signify a double bond; or the two bonds characterised by wavy lines are absent in ring B and replaced by a total of 4 hydrogen atoms, and the two wavy lines in ring A each, together with the respective parallel bond, signify a double bond; or both in ring A and in ring B all of the 4 wavy bonds are absent and are replaced by a total of 8 hydrogen atoms; or a salt thereof, if at least one salt-forming group is present. These have, for example, an antitumour effect.
PE00059998A 1997-07-07 1998-07-03 PARTIALLY HYDROGENATED POLYCLIC COMPOUNDS PE84299A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH164697 1997-07-07
CH214597 1997-09-11

Publications (1)

Publication Number Publication Date
PE84299A1 true PE84299A1 (en) 1999-09-09

Family

ID=25688257

Family Applications (1)

Application Number Title Priority Date Filing Date
PE00059998A PE84299A1 (en) 1997-07-07 1998-07-03 PARTIALLY HYDROGENATED POLYCLIC COMPOUNDS

Country Status (4)

Country Link
AU (1) AU8856298A (en)
CO (1) CO4940430A1 (en)
PE (1) PE84299A1 (en)
WO (1) WO1999002532A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917990A1 (en) * 1999-04-20 2000-11-02 Florian Lang Medicament containing inhibitors of cell volume regulated human kinase h-sgk
WO2001004125A1 (en) * 1999-07-13 2001-01-18 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives
FR2801054B1 (en) * 1999-11-17 2003-06-13 Adir NOVEL DERIVATIVES OF 12,13- (PYRANOSYL) -INDOLO [2,3-A] PYRROLO [3,4-C] CARBAZOLE AND 12,13- (PYRANOSYL) -FURO [3,4-C] INDOLO [2,3 -A] CARBAZOLE, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE10042137A1 (en) * 2000-08-28 2002-03-14 Florian Lang sgk2 and sgk3 as diagnostic and therapeutic targets
US6677450B2 (en) * 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
PT1339458E (en) * 2000-11-22 2007-11-09 Novartis Ag Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
US6855698B2 (en) 2001-03-22 2005-02-15 Bristol-Myers Squibb Company Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
DE10294485T5 (en) 2001-10-29 2004-04-29 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Proteins homologous with Mnk kinase, which are involved in the regulation of energy homeostasis and organelle metabolism
HU230798B1 (en) 2001-10-30 2018-06-28 Novartis Ag Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
CN1638777A (en) * 2002-01-25 2005-07-13 法玛西雅公司 Aldosterone blocker therapy to prevent or treat inflammation-related disorders
EP1653973A1 (en) 2003-08-08 2006-05-10 Novartis AG Combinations comprising staurosporines
ES2326459B1 (en) 2008-04-08 2010-05-28 Universidad De Oviedo GLYCOLSILATED INDOLOCARBAZOLS, ITS PROCESSING PROCEDURE AND ITS USES.
CN102101866A (en) * 2010-11-04 2011-06-22 中国海洋大学 Halogenated derivatives of staurosporine, and preparation method thereof and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
EP0703917A1 (en) * 1993-06-17 1996-04-03 Novartis AG Indolocarbazole compound useful as proteinkinase c inhibitor
AU2565995A (en) * 1994-06-01 1995-12-21 Ciba-Geigy Ag Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
WO1997007081A2 (en) * 1995-08-11 1997-02-27 Yale University Glycosylated indolocarbazole synthesis

Also Published As

Publication number Publication date
WO1999002532A2 (en) 1999-01-21
WO1999002532A3 (en) 1999-04-01
CO4940430A1 (en) 2000-07-24
AU8856298A (en) 1999-02-08

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal