PE21995A1 - Derivado de 2-carboxiindol - Google Patents
Derivado de 2-carboxiindolInfo
- Publication number
- PE21995A1 PE21995A1 PE1994252640A PE25264094A PE21995A1 PE 21995 A1 PE21995 A1 PE 21995A1 PE 1994252640 A PE1994252640 A PE 1994252640A PE 25264094 A PE25264094 A PE 25264094A PE 21995 A1 PE21995 A1 PE 21995A1
- Authority
- PE
- Peru
- Prior art keywords
- derivative
- adylene
- carboxyindol
- amino
- stricnin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN DERIVADO DE INDOL DE FORMULA I DONDE: 1) R ES HALOGENO, ALQUILO, ALCOXI, AMINO, ALQUILAMINO Y OTROS, DE PREFERENCIA ES CLORO; 2) R1 ES CICLOALQUILO, HETEROARILO, HETEROCICLO, FENILO, CARBOCICLO BICICLICO FUSIONADO, DE PREFERENCIA FENILO OPCIONALMENTE SUSTITUIDO, 1-NAFTILO, 2-PIRIDILO, QUINOLINILO, CICLOHEXILO, 2-ADAMANTILO; 3) A ES -(CH2)2-, -(CH2)3-, -CH2CO-, -CH2NH-, -CH2-N(CH3)-, -(CH2)2-NH-, -NHCO-, -CH2O-, 4) m VARIA DE 0 A 2; EL CUAL PUEDE SER ANTAGONISTA DE AMINOACIDOS EXCITADORES EN EL SITIO DE UNION DE LA GLICINA INSENSIBLE A ESTRICNINA LOCALIZADO SOBRE EL COMPLEJO DEL RECEPTOR DE N-METIL-D-ASPARTATO (NMDA), SIENDO UTIL EN EL TRATAMIENTO DE DANO NEUROTOXICO O ENFERMEDADES NEURODEGENERATIVAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939321221A GB9321221D0 (en) | 1993-10-14 | 1993-10-14 | Heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE21995A1 true PE21995A1 (es) | 1995-08-14 |
Family
ID=10743550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1994252640A PE21995A1 (es) | 1993-10-14 | 1994-10-12 | Derivado de 2-carboxiindol |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US5760059A (es) |
| EP (1) | EP0723541A1 (es) |
| JP (1) | JPH09503770A (es) |
| CN (1) | CN1070490C (es) |
| AP (1) | AP574A (es) |
| AU (1) | AU681194B2 (es) |
| BG (1) | BG61839B1 (es) |
| CA (1) | CA2171449A1 (es) |
| CO (1) | CO4290355A1 (es) |
| CZ (1) | CZ92396A3 (es) |
| FI (1) | FI961628A7 (es) |
| GB (1) | GB9321221D0 (es) |
| HU (1) | HU219710B (es) |
| IL (1) | IL111294A (es) |
| IS (1) | IS4219A (es) |
| MY (1) | MY112411A (es) |
| NO (1) | NO309861B1 (es) |
| NZ (1) | NZ274179A (es) |
| OA (1) | OA10578A (es) |
| PE (1) | PE21995A1 (es) |
| PL (1) | PL179568B1 (es) |
| RU (1) | RU2144535C1 (es) |
| SG (1) | SG49013A1 (es) |
| SK (1) | SK44996A3 (es) |
| TW (1) | TW283144B (es) |
| WO (1) | WO1995010517A1 (es) |
| ZA (1) | ZA947948B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
| GB9704499D0 (en) * | 1997-03-05 | 1997-04-23 | Glaxo Wellcome Spa | Method of manufacture |
| GB9704498D0 (en) * | 1997-03-05 | 1997-04-23 | Glaxo Wellcome Spa | Chemical compound |
| WO2000056711A1 (en) * | 1999-03-23 | 2000-09-28 | Sumitomo Pharmaceuticals Co., Ltd. | Tricyclic indole-2-carboxylic acid compound used as nmda receptor antagonist |
| RU2209041C2 (ru) * | 2000-06-15 | 2003-07-27 | Новосибирский научно-исследовательский институт травматологии и ортопедии | Способ лечения церебрального вазоспазма |
| DE10153346A1 (de) | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
| US20030162825A1 (en) * | 2001-11-09 | 2003-08-28 | Sepracor Inc. | D-amino acid oxidase inhibitors for learning and memory |
| WO2005066135A2 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
| US20080293726A1 (en) | 2005-07-06 | 2008-11-27 | Sepracor Inc. | Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders |
| WO2007063010A1 (en) * | 2005-12-01 | 2007-06-07 | F. Hoffmann-La Roche Ag | Novel vinylogous acids derivatives |
| US20070203111A1 (en) * | 2006-01-06 | 2007-08-30 | Sepracor Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| JP5438975B2 (ja) * | 2006-01-06 | 2014-03-12 | サノビオン ファーマシューティカルズ インク | テトラロン系モノアミン再取り込み阻害剤 |
| WO2007115185A2 (en) | 2006-03-31 | 2007-10-11 | Sepracor Inc. | Preparation of chiral amides and amines |
| US7884124B2 (en) * | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
| US20080082066A1 (en) * | 2006-10-02 | 2008-04-03 | Weyerhaeuser Co. | Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks |
| US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| JP2010516697A (ja) | 2007-01-18 | 2010-05-20 | セプラコール インク． | Ｄ−アミノ酸オキシダーゼ阻害剤 |
| RU2470011C2 (ru) | 2007-05-31 | 2012-12-20 | Сепракор Инк. | Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов |
| WO2010017418A1 (en) * | 2008-08-07 | 2010-02-11 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
| JP2010235597A (ja) * | 2009-03-10 | 2010-10-21 | Santen Pharmaceut Co Ltd | ４，６−ジクロロ−１ｈ−インドール−２−カルボン酸誘導体又はその塩を有効成分として含有する視神経障害の予防又は治療剤 |
| WO2011017634A2 (en) * | 2009-08-07 | 2011-02-10 | Sepracore Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
| EP2763676B1 (en) | 2011-10-03 | 2019-12-25 | The University of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
| IL248567B (en) | 2014-04-30 | 2022-08-01 | Univ Nat Taiwan | Use of compounds known as d-amino acid oxidase inhibitors |
| NZ779170A (en) | 2016-09-14 | 2025-08-29 | Univ Nat Taiwan | Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
| US4960786A (en) * | 1989-04-24 | 1990-10-02 | Merrell Dow Pharmaceuticals Inc. | Excitatory amino acid antagonists |
| PT93943A (pt) * | 1989-05-05 | 1991-02-08 | Searle & Co | Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc |
| DE4101686A1 (de) * | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | Indolderivate |
| US5284862A (en) * | 1991-03-18 | 1994-02-08 | Warner-Lambert Company | Derivatives of 2-carboxyindoles having pharmaceutical activity |
| US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
| EP0545478A1 (en) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclic compounds as tachykinin antagonists |
| GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| ZA936492B (en) * | 1992-09-10 | 1995-03-02 | Lilly Co Eli | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease. |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
-
1993
- 1993-10-14 GB GB939321221A patent/GB9321221D0/en active Pending
-
1994
- 1994-10-10 IS IS4219A patent/IS4219A/is unknown
- 1994-10-11 MY MYPI94002695A patent/MY112411A/en unknown
- 1994-10-12 WO PCT/EP1994/003359 patent/WO1995010517A1/en not_active Ceased
- 1994-10-12 RU RU96108920A patent/RU2144535C1/ru active
- 1994-10-12 HU HU9600969A patent/HU219710B/hu not_active IP Right Cessation
- 1994-10-12 SK SK449-96A patent/SK44996A3/sk unknown
- 1994-10-12 PE PE1994252640A patent/PE21995A1/es not_active Application Discontinuation
- 1994-10-12 US US08/619,510 patent/US5760059A/en not_active Expired - Fee Related
- 1994-10-12 CN CN94193759A patent/CN1070490C/zh not_active Expired - Fee Related
- 1994-10-12 AP APAP/P/1994/000685A patent/AP574A/en active
- 1994-10-12 NZ NZ274179A patent/NZ274179A/en unknown
- 1994-10-12 PL PL94313969A patent/PL179568B1/pl unknown
- 1994-10-12 SG SG1996005195A patent/SG49013A1/en unknown
- 1994-10-12 JP JP7511283A patent/JPH09503770A/ja active Pending
- 1994-10-12 CO CO94046673A patent/CO4290355A1/es unknown
- 1994-10-12 ZA ZA947948A patent/ZA947948B/xx unknown
- 1994-10-12 CA CA002171449A patent/CA2171449A1/en not_active Abandoned
- 1994-10-12 CZ CZ96923A patent/CZ92396A3/cs unknown
- 1994-10-12 EP EP94928893A patent/EP0723541A1/en not_active Withdrawn
- 1994-10-12 AU AU78133/94A patent/AU681194B2/en not_active Ceased
- 1994-10-13 IL IL11129494A patent/IL111294A/en not_active IP Right Cessation
- 1994-11-18 TW TW083110700A patent/TW283144B/zh active
-
1996
- 1996-04-09 OA OA60812A patent/OA10578A/en unknown
- 1996-04-12 NO NO961475A patent/NO309861B1/no not_active IP Right Cessation
- 1996-04-12 FI FI961628A patent/FI961628A7/fi unknown
- 1996-04-16 BG BG100511A patent/BG61839B1/bg unknown
-
1998
- 1998-05-29 US US09/086,522 patent/US5962496A/en not_active Expired - Lifetime
-
1999
- 1999-08-16 US US09/374,982 patent/US6100289A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE21995A1 (es) | Derivado de 2-carboxiindol | |
| PE20010741A1 (es) | Derivados de piperazina como antagonistas de taquicininas | |
| DE69319235D1 (de) | Perhydroisoindole derivate als substanz p antagonisten | |
| PE91798A1 (es) | Pirrolicarboxanilidas condensadas: utiles como ligandos receptores | |
| PE20010930A1 (es) | Bifenil sulfonamidas como antagonistas de receptores de angiotensina endotelina duales | |
| FI913503A0 (fi) | Bensimidazoler, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning. | |
| YU45293A (sh) | Morfolin i tiomorfolin tahikinin antagonisti receptora | |
| EA200300717A1 (ru) | Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов | |
| DE69230013D1 (de) | Fibrinogen-Rezeptor-Antagonisten | |
| DE69224552D1 (de) | Fibrinogen-Rezeptor-Antagonisten | |
| DE69131311D1 (de) | Fibrinogen-Rezeptor-Antagonisten | |
| ATE135687T1 (de) | Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel | |
| NZ510551A (en) | Substituted 3-cyanoquinolines useful as protein tyrosine kinases inhibitors | |
| ATE219077T1 (de) | Endothelin antagoniste | |
| FI901739A0 (fi) | Bensimidazoler, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning. | |
| PE20060243A1 (es) | Derivados de 4-amino insustituido-5-(4-urea-fenil)-pirrolotriazina | |
| DE69017593D1 (de) | Substituierte N-(Imidazolyl)alkyl-alanin-Derivate. | |
| CY1106113T1 (el) | Παραγωγα 4-φαινυλ-πυριδινης ως ανταγωνιστες του υποδοχεα νευροκινινης-1 | |
| PE75199A1 (es) | Derivado de quinolina util como antagonista de neuroquinina | |
| PE69398A1 (es) | Antagonistas de receptor de benzoxazinona dopamina d4 | |
| PE20090629A1 (es) | Pirazinas y piperidinas piperazinil sustituidas como antagonistas del receptor 5-ht7 | |
| TR200102585T2 (tr) | Bifenil türevleri | |
| PE14896A1 (es) | Aminoalcanimidazoles y triazoles acilados | |
| TR199802552T2 (xx) | 5-HT-2C Resept�r kar��tlar� olarak faydal� indolin t�revleri. | |
| DE60326430D1 (de) | Varianten von säugerprolactin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AE | Restoration of lapsed or forfeited application | ||
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |