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PE20230387A1 - Tratamiento conjunto con pbmc modificadas y un inmunoconjugado - Google Patents

Tratamiento conjunto con pbmc modificadas y un inmunoconjugado

Info

Publication number
PE20230387A1
PE20230387A1 PE2022002619A PE2022002619A PE20230387A1 PE 20230387 A1 PE20230387 A1 PE 20230387A1 PE 2022002619 A PE2022002619 A PE 2022002619A PE 2022002619 A PE2022002619 A PE 2022002619A PE 20230387 A1 PE20230387 A1 PE 20230387A1
Authority
PE
Peru
Prior art keywords
polypeptide
immunoconjugate
treatment
administering
variant
Prior art date
Application number
PE2022002619A
Other languages
English (en)
Inventor
Pablo Umana
Christian Klein
Christine Trumpfheller
Valeria G Nicolini
Deak Laura Codarri
Scott Loughhead
Matthew Booty
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20230387A1 publication Critical patent/PE20230387A1/es

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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract

La presente solicitud proporciona metodos para estimular una respuesta inmunitaria en un individuo que comprende administrar una composicion de celulas nucleadas (por ejemplo, PBMC) que comprende un antigeno exogeno intracelular en conjunto con la administracion de un inmunoconjugado que comprende un polipeptido de IL-2 variante y un segundo polipeptido. El polipeptido de IL-2 variante exhibe afinidad reducida a la subunidad a del receptor de IL-2. El segundo polipeptido actua sobre una celula tumoral o un linfocito T.
PE2022002619A 2020-05-11 2021-05-10 Tratamiento conjunto con pbmc modificadas y un inmunoconjugado PE20230387A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063023193P 2020-05-11 2020-05-11
US202063105135P 2020-10-23 2020-10-23
PCT/US2021/031542 WO2021231278A1 (en) 2020-05-11 2021-05-10 Combination therapy with modified pbmcs and an immunoconjugate

Publications (1)

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PE20230387A1 true PE20230387A1 (es) 2023-03-06

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US (1) US20230181712A1 (es)
EP (1) EP4149524A1 (es)
JP (1) JP2023527690A (es)
KR (1) KR20230010240A (es)
CN (1) CN115551540A (es)
AU (1) AU2021272340A1 (es)
BR (1) BR112022022614A2 (es)
CA (1) CA3177288A1 (es)
CL (1) CL2022003130A1 (es)
CR (1) CR20220576A (es)
IL (1) IL298038A (es)
MX (1) MX2022014134A (es)
PE (1) PE20230387A1 (es)
TW (1) TW202207975A (es)
WO (1) WO2021231278A1 (es)

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CN116323647A (zh) 2020-05-13 2023-06-23 博纳姆治疗公司 蛋白质复合物的组合物及其使用方法
WO2024068705A1 (en) * 2022-09-29 2024-04-04 F. Hoffmann-La Roche Ag Protease-activated polypeptides

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
DE3676670D1 (de) 1985-06-26 1991-02-07 Cetus Corp Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung.
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
JP4213224B2 (ja) 1997-05-02 2009-01-21 ジェネンテック，インコーポレーテッド ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
JP2003512821A (ja) 1999-10-04 2003-04-08 メディカゴ インコーポレイテッド 外来性遺伝子の転写調節方法
ATE542137T1 (de) 2001-12-04 2012-02-15 Merck Patent Gmbh Immunocytokine mit modulierter selektivität
PT1871805T (pt) 2005-02-07 2019-12-02 Roche Glycart Ag Moléculas de ligação a antigénios que se ligam ao rfce, vetores que as codificam e as suas utilizações
CN101198698B (zh) 2005-03-31 2014-03-19 中外制药株式会社 通过调节多肽缔合制备多肽的方法
DK1999154T3 (da) 2006-03-24 2012-12-03 Merck Patent Gmbh Fremstillede heterodimere proteindomæner
EP2035456A1 (en) 2006-06-22 2009-03-18 Novo Nordisk A/S Production of bispecific antibodies
AU2009204501B2 (en) 2008-01-07 2015-02-12 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
WO2010129304A2 (en) 2009-04-27 2010-11-11 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
CN105693861A (zh) 2009-12-29 2016-06-22 新兴产品开发西雅图有限公司 异二聚体结合蛋白及其应用
JP6022444B2 (ja) 2010-05-14 2016-11-09 ライナット ニューロサイエンス コーポレイション ヘテロ二量体タンパク質ならびにそれを生産および精製するための方法
MA34519B1 (fr) 2010-08-13 2013-09-02 Roche Glycart Ag Anticorps anti-fap et procédés d'utilisation
HUE047228T2 (hu) 2010-11-05 2020-04-28 Zymeworks Inc Stabil heterodimer antitest-kialakítás az FC doménben mutációval
PL3489255T3 (pl) 2011-02-10 2021-11-22 Roche Glycart Ag Zmutowane polipeptydy interleukiny-2
BR112013024574B1 (pt) 2011-03-29 2022-08-09 Roche Glycart Ag Anticorpo e uso do anticorpo
EP3608394A1 (en) 2011-10-17 2020-02-12 Massachusetts Institute Of Technology Intracellular delivery
RS60499B1 (sr) 2011-12-20 2020-08-31 Medimmune Llc Modifikovani polipeptidi za bispecifične skelete antitela
WO2013157953A1 (en) 2012-04-20 2013-10-24 Merus B.V. Methods and means for the production of ig-like molecules
JP6502940B2 (ja) 2013-08-16 2019-04-17 マサチューセッツ インスティテュート オブ テクノロジー 細胞への物質の選択的送達
US11111472B2 (en) 2014-10-31 2021-09-07 Massachusetts Institute Of Technology Delivery of biomolecules to immune cells
CN107922911A (zh) 2015-07-09 2018-04-17 麻省理工学院 将物质递送至无核细胞
EP3344747B1 (en) 2015-09-04 2022-11-09 SQZ Biotechnologies Company Intracellular delivery of biomolecules mediated by a surface with pores
CA3023092A1 (en) 2016-05-03 2017-11-09 Sqz Biotechnologies Company Intracellular delivery of biomolecules to induce tolerance
CN109475577A (zh) 2016-05-03 2019-03-15 Sqz生物技术公司 细胞内递送生物分子以诱导耐受性
CN117003887A (zh) 2017-04-03 2023-11-07 豪夫迈·罗氏有限公司 抗pd-1抗体与突变体il-2或与il-15的免疫缀合物
KR20200130371A (ko) 2018-03-12 2020-11-18 에스큐지 바이오테크놀로지스 컴퍼니 Hpv-연관 질환을 치료하는 방법
AU2019234550B2 (en) 2018-03-12 2025-12-04 Sqz Biotechnologies Company Intracellular delivery of biomolecules to modify immune response
KR20210070338A (ko) 2018-10-04 2021-06-14 에스큐지 바이오테크놀로지스 컴퍼니 항원 제시 세포 기능을 증진시키기 위한 생체분자의 세포내 전달
US11692168B2 (en) * 2019-02-28 2023-07-04 Sqz Biotechnologies Company Delivery of biomolecules to PBMCs to modify an immune response

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