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PE20212158A1 - Composicion farmaceutica acuosa de anticuerpo anti-il17a y su uso - Google Patents

Composicion farmaceutica acuosa de anticuerpo anti-il17a y su uso

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Publication number
PE20212158A1
PE20212158A1 PE2021001668A PE2021001668A PE20212158A1 PE 20212158 A1 PE20212158 A1 PE 20212158A1 PE 2021001668 A PE2021001668 A PE 2021001668A PE 2021001668 A PE2021001668 A PE 2021001668A PE 20212158 A1 PE20212158 A1 PE 20212158A1
Authority
PE
Peru
Prior art keywords
compositions
il17a
il17a antibody
pharmaceutical composition
variable domain
Prior art date
Application number
PE2021001668A
Other languages
English (en)
Inventor
Ekaterina Valerevna Cherniaeva
Ekaterina Aleksandrovna Lomkova
Antonina Vasilevna Artemeva
Anna Viktorovna Eremeeva
Roman Alekseevich Ivanov
Anastasiya Mikhajlovna Ryakhovskaya
Viktoriia Olegovna Shitikova
Aleksandr Olegovich Iakovlev
Dmitry Valentinovich Morozov
Original Assignee
Biocad Joint Stock Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Joint Stock Co filed Critical Biocad Joint Stock Co
Publication of PE20212158A1 publication Critical patent/PE20212158A1/es

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    • A61K39/39591—Stabilisation, fragmentation
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

Esta divulgacion se refiere a composiciones acuosas de anticuerpos anti-IL17a y, particularmente, a composiciones acuosas de anticuerpos anti-IL17a con un dominio variable VHH y un dominio variable VL. Estas composiciones pueden ser utilizadas como agentes medicinales para tratar enfermedades mediadas por IL-17A. Tambien se refiere a una composicion farmaceutica acuosa para administracion parenteral a un sujeto para inhibir la actividad de la proteina IL17a que comprende: un anticuerpo anti-IL17a que comprende un dominio derivado de VHH y un dominio VL variable; un agente tampon a base de histidina; y una cantidad eficaz de un alcohol a base de azucar como un agente osmotico. Estas composiciones se emplean en el tratamiento de artritis reumatoide, enfermedad de Crohn, psoriasis, asma, entre otras.
PE2021001668A 2019-04-02 2020-04-02 Composicion farmaceutica acuosa de anticuerpo anti-il17a y su uso PE20212158A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2019109641A RU2754760C2 (ru) 2019-04-02 2019-04-02 Водная фармацевтическая композиция анти-il17a антитела и ее применение
PCT/RU2020/050065 WO2020204765A1 (en) 2019-04-02 2020-04-02 Aqueous pharmaceutical composition of an anti-il17a antibody and use thereof

Publications (1)

Publication Number Publication Date
PE20212158A1 true PE20212158A1 (es) 2021-11-09

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US (1) US12534525B2 (es)
EP (1) EP3946454A4 (es)
JP (2) JP2022528119A (es)
KR (1) KR20220010483A (es)
CN (1) CN110898220B (es)
AR (1) AR118571A1 (es)
AU (1) AU2020255987A1 (es)
BR (1) BR112021019903A2 (es)
CA (1) CA3135357A1 (es)
CL (1) CL2021002574A1 (es)
CO (1) CO2021013244A2 (es)
CR (1) CR20210507A (es)
EC (1) ECSP21074141A (es)
IL (1) IL286867A (es)
JO (1) JOP20210269A1 (es)
MA (1) MA54663A1 (es)
MX (1) MX2021011995A (es)
PE (1) PE20212158A1 (es)
PH (1) PH12021552521A1 (es)
RU (1) RU2754760C2 (es)
SG (1) SG11202110848TA (es)
TW (2) TWI844034B (es)
UY (1) UY38629A (es)
WO (1) WO2020204765A1 (es)
ZA (1) ZA202107587B (es)

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RU2745814C1 (ru) * 2020-06-05 2021-04-01 Закрытое Акционерное Общество "Биокад" Водная фармацевтическая композиция левилимаба и ее применение
CN115746132B (zh) * 2021-09-03 2023-09-08 三优生物医药(上海)有限公司 抗il-17a抗体及其用途
CN116510006A (zh) * 2022-01-31 2023-08-01 拜奥卡德联合股份公司 抗trbv9抗体的药物组合物及其用途
WO2024240224A1 (zh) * 2023-05-23 2024-11-28 再鼎医药(上海)有限公司 包含抗ccr8抗体的制剂及其用途
CN116593718B (zh) * 2023-07-18 2023-09-15 军科正源（北京）药物研究有限责任公司 用于检测司库奇尤单抗抗药性抗体的试剂
CN117820475B (zh) * 2023-12-21 2024-10-29 北京贝来生物科技有限公司 针对il-17a的新型纳米抗体、药物、制备、方法及应用
CN118078988A (zh) * 2024-04-19 2024-05-28 正大天晴药业集团南京顺欣制药有限公司 包含靶向il-17a的抗体药物组合物

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