[go: up one dir, main page]

PE20210475A1 - Anticuerpos especificos para el transcrito similar a la inmoglubina tipo 3 (ilt3) y sus usos - Google Patents

Anticuerpos especificos para el transcrito similar a la inmoglubina tipo 3 (ilt3) y sus usos

Info

Publication number
PE20210475A1
PE20210475A1 PE2020000691A PE2020000691A PE20210475A1 PE 20210475 A1 PE20210475 A1 PE 20210475A1 PE 2020000691 A PE2020000691 A PE 2020000691A PE 2020000691 A PE2020000691 A PE 2020000691A PE 20210475 A1 PE20210475 A1 PE 20210475A1
Authority
PE
Peru
Prior art keywords
ilt3
type
immoglubin
specific antibodies
similar transcript
Prior art date
Application number
PE2020000691A
Other languages
English (en)
Inventor
Michael A Meehl
Philip E Brandish
Laurence Fayadat-Dilman
Veronica Juan
Carl Mieczkowski
Latika Ingh
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20210475A1 publication Critical patent/PE20210475A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen anticuerpos monoclonales no promiscuos humanizados especificos para el transcrito similar a la inmunoglobulina tipo 3 (ILT3), tambien conocido como receptor de tipo inmunoglobulina de leucocitos de la subfamilia B miembro 4 (LILRB4).
PE2020000691A 2017-11-17 2018-11-15 Anticuerpos especificos para el transcrito similar a la inmoglubina tipo 3 (ilt3) y sus usos PE20210475A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762587604P 2017-11-17 2017-11-17
PCT/US2018/061165 WO2019099597A2 (en) 2017-11-17 2018-11-15 Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof

Publications (1)

Publication Number Publication Date
PE20210475A1 true PE20210475A1 (es) 2021-03-08

Family

ID=64572590

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000691A PE20210475A1 (es) 2017-11-17 2018-11-15 Anticuerpos especificos para el transcrito similar a la inmoglubina tipo 3 (ilt3) y sus usos

Country Status (26)

Country Link
US (6) US11111297B2 (es)
EP (1) EP3710479A2 (es)
JP (1) JP7194481B2 (es)
KR (1) KR102478433B1 (es)
CN (2) CN111712518B (es)
AR (1) AR113696A1 (es)
AU (1) AU2018367524B2 (es)
BR (1) BR112020009759A8 (es)
CA (1) CA3082409A1 (es)
CL (1) CL2020001240A1 (es)
CO (1) CO2020006405A2 (es)
CR (1) CR20200204A (es)
DO (1) DOP2020000074A (es)
EA (1) EA202091228A1 (es)
EC (1) ECSP20032082A (es)
GE (2) GEAP202315366A (es)
IL (1) IL274574A (es)
JO (1) JOP20200131A1 (es)
MA (1) MA50900A (es)
MX (2) MX2020005128A (es)
NI (1) NI202000036A (es)
PE (1) PE20210475A1 (es)
PH (1) PH12020550890A1 (es)
SG (1) SG11202004426SA (es)
TW (1) TWI816715B (es)
WO (1) WO2019099597A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
BR112020009759A8 (pt) * 2017-11-17 2023-01-31 Merck Sharp & Dohme Anticorpos específicos para transcrito 3 semelhante à imunoglobulina (ilt3) e usos dos mesmos
CN115746138A (zh) 2019-12-19 2023-03-07 恩格姆生物制药公司 Ilt3结合剂及其使用方法
PE20221894A1 (es) 2020-05-01 2022-12-13 Ngm Biopharmaceuticals Inc Agentes de union a ilt y metodos para su uso
AU2022239502A1 (en) * 2021-03-19 2023-10-05 Merck Sharp & Dohme Llc Methods for treating cancer with anti-ilt3 antibodies
US20250101097A1 (en) * 2021-07-28 2025-03-27 Merck Sharp & Dohme Llc Methods for treating acute myeloid leukemia with anti-ilt3 antibodies
CN116082502A (zh) * 2021-11-08 2023-05-09 复旦大学 Galectin8与LILRB4结合的调节剂及其应用
WO2023140875A1 (en) * 2022-01-19 2023-07-27 Ngm Biopharmaceuticals, Inc. Uses of ilt3-binding agents
JP2025510232A (ja) 2022-03-29 2025-04-14 エヌジーエム バイオファーマシューティカルス，インコーポレーテッド Ｉｌｔ３及びｃｄ３結合剤及びその使用方法
US20250277032A1 (en) 2022-04-25 2025-09-04 Biond Biologics Ltd. Anti-ilt3 antibodies and use thereof
WO2023235699A1 (en) 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof
CN115925942A (zh) * 2022-06-08 2023-04-07 北京科诺信诚科技有限公司 靶向人lilrb4的纳米抗体及其应用
CN119894934A (zh) 2023-05-18 2025-04-25 南京维立志博生物科技股份有限公司 结合lilrb4和cd3的抗体及其用途
WO2025062392A1 (en) 2023-09-20 2025-03-27 Biond Biologics Ltd. Anti-ilt3 blockade combinations
WO2025141589A1 (en) 2023-12-31 2025-07-03 Biond Biologics Ltd. Treatment of cancer with anti-ilt3 antibodies

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042924B1 (en) 1980-06-30 1984-03-21 International Business Machines Corporation Data transfer apparatus
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
WO1993011161A1 (en) 1991-11-25 1993-06-10 Enzon, Inc. Multivalent antigen-binding proteins
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6096002A (en) 1998-11-18 2000-08-01 Bioject, Inc. NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
CN1214043C (zh) 1998-12-01 2005-08-10 蛋白质设计实验室股份有限公司 抗γ－干扰素的人化抗体
AU2002345878A1 (en) * 2001-06-25 2003-01-08 The Trustees Of Columbia University In The City Of New York Ilt3 and ilt4-related compositions and methods
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
CA2391438A1 (en) 2002-05-01 2003-11-01 Procyon Biopharma Inc. Psp94 diagnostic reagents and assays
JP4511943B2 (ja) 2002-12-23 2010-07-28 ワイス エルエルシー Ｐｄ−１に対する抗体およびその使用
WO2006033811A2 (en) * 2004-09-03 2006-03-30 The Trustees Of Columbia University In The City Of New York Ilt3 polypeptides and uses thereof
EP2439273B1 (en) 2005-05-09 2019-02-27 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
CA2611519A1 (en) 2005-06-17 2006-12-28 Tolerx, Inc. Ilt3 binding molecules and uses therefor
HRP20151102T1 (xx) 2005-07-01 2015-11-20 E. R. Squibb & Sons, L.L.C. Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1)
RU2456298C2 (ru) * 2005-12-20 2012-07-20 ЭсБиАй БАЙОТЕК КО., ЛТД. Антитело против ilt17
US20090202544A1 (en) 2006-02-02 2009-08-13 The Trustees Of Columbia University In The City Of New York Methods of Treating Diseases by Targeting Silt3
JP5597793B2 (ja) 2006-06-19 2014-10-01 メルク・シャープ・アンド・ドーム・コーポレーション Ｉｌｔ３結合分子およびその使用
GB0705775D0 (en) 2007-03-26 2007-05-02 Affitech As Product
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
WO2009036379A2 (en) 2007-09-14 2009-03-19 Adimab, Inc. Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
ES2639857T3 (es) 2008-02-11 2017-10-30 Cure Tech Ltd. Anticuerpos monoclonales para el tratamiento del tumor
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
AU2009288730B2 (en) 2008-08-25 2013-06-20 Amplimmune, Inc. Compositions of PD-1 antagonists and methods of use
EA201170375A1 (ru) 2008-08-25 2012-03-30 Эмплиммьюн, Инк. Антагонисты pd-1 и способы их применения
SMT202500126T1 (it) 2008-12-09 2025-05-12 Hoffmann La Roche Anticorpi anti-pd-l1 e loro uso per potenziare la funzione dei linfociti t
ES2629337T3 (es) 2009-02-09 2017-08-08 Inserm - Institut National De La Santé Et De La Recherche Médicale Anticuerpos contra PD-1 y anticuerpos contra PD-L1 y usos de los mismos
CN101830978A (zh) * 2009-03-09 2010-09-15 中国科学院微生物研究所 一种人免疫球蛋白样受体突变体及其应用
JP2013512251A (ja) 2009-11-24 2013-04-11 アンプリミューン、インコーポレーテッド Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害
MX341925B (es) 2010-03-29 2016-09-07 Zymeworks Inc Anticuerpos con funcion efectora suprimida o mejorada.
NZ701408A (en) 2010-04-16 2016-01-29 Medvet Science Pty Ltd Proteins that bind pi16 and uses thereof
BR112013024574B1 (pt) 2011-03-29 2022-08-09 Roche Glycart Ag Anticorpo e uso do anticorpo
WO2013033734A1 (en) * 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand
WO2013043569A1 (en) 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
US20150174203A1 (en) 2012-05-30 2015-06-25 Icahn School Of Medicine At Mount Sinai Compositions And Methods For Modulating Pro-Inflammatory Immune Response
US20140242077A1 (en) 2013-01-23 2014-08-28 Abbvie, Inc. Methods and compositions for modulating an immune response
IL242088B2 (en) 2013-05-20 2023-12-01 Genentech Inc Anti-transferrin receptor antibodies and methods of use
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
EA034921B1 (ru) 2014-09-28 2020-04-07 Зе Реджентс Оф Зе Юниверсити Оф Калифорния Модуляция стимулирующих и нестимулирующих миелоидных клеток
CN106063395B (zh) 2015-02-15 2019-06-11 华为技术有限公司 电子设备外壳的加工方法、电子设备外壳及电子设备
WO2016144728A2 (en) 2015-03-06 2016-09-15 The Board Of Regents Of The University Of Texas System Anti-lilrb antibodies and their use in detecting and treating cancer
US10765742B2 (en) 2015-07-17 2020-09-08 The Trustees Of Columbia University In The City Of New York Methods of treating CD166-expressing cancer
WO2017087589A2 (en) 2015-11-18 2017-05-26 Merck Sharp & Dohme Corp. Pd1 and/or lag3 binders
CN109906381B (zh) 2016-08-31 2023-03-31 新加坡科技研究局 鉴别、靶向以及分离人树突细胞(dc)前体“前dc”的方法及其用途
EP3538141A4 (en) * 2016-11-10 2020-07-15 Merck Sharp & Dohme Corp. LIGAND ILT3
CA3053164A1 (en) 2017-02-09 2018-08-16 Bluefin Biomedicine, Inc. Anti-ilt3 antibodies and antibody drug conjugates
BR112020009759A8 (pt) * 2017-11-17 2023-01-31 Merck Sharp & Dohme Anticorpos específicos para transcrito 3 semelhante à imunoglobulina (ilt3) e usos dos mesmos
AU2022239502A1 (en) * 2021-03-19 2023-10-05 Merck Sharp & Dohme Llc Methods for treating cancer with anti-ilt3 antibodies
US20250101097A1 (en) * 2021-07-28 2025-03-27 Merck Sharp & Dohme Llc Methods for treating acute myeloid leukemia with anti-ilt3 antibodies
IL310769A (en) * 2021-08-11 2024-04-01 Oncohost Ltd Predicting patient response
US20250179173A1 (en) * 2022-02-17 2025-06-05 Immune-Onc Therapeutics, Inc. Combination therapy of lilrb antagonist and pd-1/pd-l1 axis inhibitor
WO2023235699A1 (en) * 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof
EP4561623A1 (en) * 2022-07-28 2025-06-04 Merck Sharp & Dohme LLC Methods for treating chronic myelomonocytic leukemia with anti-ilt3 antibodies

Also Published As

Publication number Publication date
US12441792B2 (en) 2025-10-14
TWI816715B (zh) 2023-10-01
US20220025042A1 (en) 2022-01-27
MX2020005128A (es) 2020-07-27
NI202000036A (es) 2020-09-24
IL274574A (en) 2020-06-30
CL2020001240A1 (es) 2020-12-18
AU2018367524B2 (en) 2022-09-15
WO2019099597A3 (en) 2019-06-13
CR20200204A (es) 2020-06-18
CN120058946A (zh) 2025-05-30
GEP20237565B (en) 2023-11-10
BR112020009759A8 (pt) 2023-01-31
JP2021503280A (ja) 2021-02-12
CO2020006405A2 (es) 2020-06-09
BR112020009759A2 (pt) 2020-11-03
US20190153093A1 (en) 2019-05-23
KR102478433B1 (ko) 2022-12-15
JP7194481B2 (ja) 2022-12-22
AR113696A1 (es) 2020-06-03
MA50900A (fr) 2020-09-23
US11111297B2 (en) 2021-09-07
US12435133B2 (en) 2025-10-07
SG11202004426SA (en) 2020-06-29
US20220033497A1 (en) 2022-02-03
GEAP202315366A (en) 2023-07-25
US20220025043A1 (en) 2022-01-27
KR20200083598A (ko) 2020-07-08
PH12020550890A1 (en) 2021-04-12
US20220010011A1 (en) 2022-01-13
JOP20200131A1 (ar) 2020-05-28
TW201922786A (zh) 2019-06-16
DOP2020000074A (es) 2020-08-31
US20220010010A1 (en) 2022-01-13
MX2025000940A (es) 2025-03-07
ECSP20032082A (es) 2020-08-31
CA3082409A1 (en) 2019-05-23
EP3710479A2 (en) 2020-09-23
CN111712518B (zh) 2025-03-25
CN111712518A (zh) 2020-09-25
AU2018367524A1 (en) 2020-06-11
EA202091228A1 (ru) 2020-08-12
WO2019099597A2 (en) 2019-05-23

Similar Documents

Publication Publication Date Title
ECSP20032082A (es) Anticuerpos específicos para el transcrito similar a la inmunoglobulina tipo 3 (ilt3) y sus usos
ZA202211577B (en) Multivalent and multispecific 41bb-binding fusion proteins
BR112022010206A2 (pt) Receptores de antígeno quiméricos e usos dos mesmos
CL2020000938A1 (es) Anticuerpos anti-tigit, sus composiciones y uso. (divisional solicitud 201800744)
MX2021012720A (es) Celulas t de receptor de antigeno quimerico co-estimulador que toman como diana a il13r-alfa-2.
AR105767A1 (es) Proteínas de fusión de unión a gitr multivalentes y multiespecíficas
CL2019000628A1 (es) Anticuerpos anti-pd-1 y sus usos.
ECSP17083779A (es) Agentes de unión a inmunorreceptor de células t con dominios ig y motivo de inhibición basado en tirosina de inmunorreceptor (tigit) y usos de los mismos
CO2017006740A2 (es) Anticuerpos anti–cd79b
MX389021B (es) Inmunoreceptores especificos de claudina-18.2 y epitopos de celulas t.
MX2018001530A (es) Anticuerpos anti-pd-l1 novedosos.
MX376026B (es) Inmunoreceptores especificos de claudina-6 y epitopos de celulas t.
MX389547B (es) Moleculas de union que inhibe el crecimiento de cancer.
MX385156B (es) Receptores de antígeno quimérico que se dirigen al receptor acoplado a la proteína g y sus usos.
MX2020003132A (es) Anticuerpos anti-ctla4 y usos de los mismos.
MX2018001398A (es) Anticuerpos monoclonales contra bcma.
MX385456B (es) Anticuerpos cd123 y conjugados de los mismos.
MX2023002379A (es) Proteinas de fusion de union a dr5 multivalentes y multiespecificas.
CY1123046T1 (el) Ζωα εκτος του ανθρωπου που εχουν ανθρωποποιημενους υποδοχεις fc-γ
UY36942A (es) Proteínas de unión a antígeno que activan el receptor de leptina
CL2018002898A1 (es) Nuevos anticuerpos anti-sirpa y sus aplicaciones terapéuticas.
MX2019011225A (es) Células t modificadas por el receptor de antígeno quimérico dirigidas a cs1 para el tratamiento de la amiloidosis al.
CO2019012756A2 (es) Anticuerpos agonistas contra btla y sus usos
BR112018009097A8 (pt) spodoptera frugiperda resistente a vip3a
MX384990B (es) Selectividad eficaz de proteínas recombinantes.