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PE20190967A1 - MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USE - Google Patents

MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USE

Info

Publication number
PE20190967A1
PE20190967A1 PE2019001065A PE2019001065A PE20190967A1 PE 20190967 A1 PE20190967 A1 PE 20190967A1 PE 2019001065 A PE2019001065 A PE 2019001065A PE 2019001065 A PE2019001065 A PE 2019001065A PE 20190967 A1 PE20190967 A1 PE 20190967A1
Authority
PE
Peru
Prior art keywords
streptomyces fungicidicus
isolates
compositions
amino acid
modified isolated
Prior art date
Application number
PE2019001065A
Other languages
Spanish (es)
Inventor
Mark T Zabriskie
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of PE20190967A1 publication Critical patent/PE20190967A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Referido a un aislado de Streptomyces fungicidicus modificado que codifica una proteina Orf2798 que tiene un 95% o mas de identidad de secuencia de aminoacidos con la secuencia SEQ ID NO:2 y comprende un residuo de serina en la posicion de aminoacido 2; obteniendose una produccion mejorada de enduracina (enramicina) en comparacion con el obtenido con una cepa Streptomyces fungicidicus de tipo silvestre. Tambien se refiere a composiciones que comprenden estos aislados, y metodos para usar tales aislados y composiciones para sintetizar biologicamente la enduracidina que facilitan su produccion de una manera mas eficienteReferred to a modified Streptomyces fungicidicus isolate encoding an Orf2798 protein that has a 95% or more amino acid sequence identity with the sequence SEQ ID NO: 2 and comprises a serine residue at amino acid position 2; obtaining an improved production of enduracin (enramycin) compared to that obtained with a Streptomyces fungicidicus strain of wild type. It also refers to compositions comprising these isolates, and methods for using such isolates and compositions to biologically synthesize enduracidin that facilitate their production in a more efficient manner.

PE2019001065A 2016-12-06 2017-09-20 MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USE PE20190967A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662430455P 2016-12-06 2016-12-06

Publications (1)

Publication Number Publication Date
PE20190967A1 true PE20190967A1 (en) 2019-07-08

Family

ID=60043150

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019001065A PE20190967A1 (en) 2016-12-06 2017-09-20 MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USE

Country Status (11)

Country Link
JP (2) JP2020500509A (en)
CN (1) CN110072881A (en)
BR (1) BR112019011603A2 (en)
CO (1) CO2019005540A2 (en)
MX (1) MX2019006586A (en)
MY (1) MY194438A (en)
PE (1) PE20190967A1 (en)
PH (1) PH12019501225A1 (en)
TW (1) TWI770070B (en)
UA (1) UA127451C2 (en)
WO (1) WO2018103905A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019006522A (en) 2016-12-06 2020-02-20 Univ Oregon State Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus.
CN115261258A (en) * 2022-06-07 2022-11-01 四川汇邦环保科技有限公司 Microbial agent for degrading duramycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617881C2 (en) 1965-10-13 1984-07-05 Takeda Chemical Industries, Ltd., Osaka Antibiotic enduracidin and its manufacture
AT269354B (en) * 1965-10-13 1969-03-10 Takeda Chemical Industries Ltd Process for the production of a new antibiotic
US3577530A (en) 1969-07-24 1971-05-04 Squibb & Sons Inc Janiemycin
JPS6038120B2 (en) * 1980-10-31 1985-08-30 武田薬品工業株式会社 Production method of the antibiotic enzyuracydin
WO2008054945A2 (en) * 2006-09-29 2008-05-08 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Enduracidin biosynthetic gene cluster from streptomyces fungicidicus
CN101974469B (en) * 2010-10-22 2012-05-23 安徽丰原发酵技术工程研究有限公司 Streptomyces fungicidious mutant strain and application thereof
CN103374537B (en) * 2012-04-25 2015-01-07 牡丹江佰佳信生物科技有限公司 Method for preparing enduracidin and strain produced thereby
CN102864114B (en) * 2012-10-19 2013-11-06 河北圣雪大成制药有限责任公司 Strain for highly yielding enramycin, and preparation method and application thereof
CN103740612A (en) * 2013-12-19 2014-04-23 河北圣雪大成制药有限责任公司 High-yield enramycin strain and screening method thereof

Also Published As

Publication number Publication date
JP2020500509A (en) 2020-01-16
BR112019011603A2 (en) 2020-08-18
MY194438A (en) 2022-11-30
WO2018103905A1 (en) 2018-06-14
MX2019006586A (en) 2019-08-22
JP2023012549A (en) 2023-01-25
PH12019501225A1 (en) 2019-09-23
RU2019117260A (en) 2021-01-11
TW201827590A (en) 2018-08-01
TWI770070B (en) 2022-07-11
CO2019005540A2 (en) 2019-05-31
RU2019117260A3 (en) 2021-01-29
UA127451C2 (en) 2023-08-30
CN110072881A (en) 2019-07-30

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PE20190967A1 (en) MODIFIED ISOLATED STREPTOMYCES FUNGICIDICUS AND ITS USE