PE20181378A1 - DIHYDROQUINOLINE-2-ONA DERIVATIVE BICYCLE COMPOUNDS AS CYP11B INHIBITORS - Google Patents
DIHYDROQUINOLINE-2-ONA DERIVATIVE BICYCLE COMPOUNDS AS CYP11B INHIBITORSInfo
- Publication number
- PE20181378A1 PE20181378A1 PE2018001330A PE2018001330A PE20181378A1 PE 20181378 A1 PE20181378 A1 PE 20181378A1 PE 2018001330 A PE2018001330 A PE 2018001330A PE 2018001330 A PE2018001330 A PE 2018001330A PE 20181378 A1 PE20181378 A1 PE 20181378A1
- Authority
- PE
- Peru
- Prior art keywords
- dihydroquinoline
- cyp11b
- ona
- inhibitors
- derivative
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102100024329 Cytochrome P450 11B2, mitochondrial Human genes 0.000 title 1
- 101000761960 Homo sapiens Cytochrome P450 11B1, mitochondrial Proteins 0.000 title 1
- 101000761956 Homo sapiens Cytochrome P450 11B2, mitochondrial Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000016998 Conn syndrome Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 125000005347 halocycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- LVDKZTHQIJVVBW-UHFFFAOYSA-N n-[4-(1-methyl-2-oxo-3,4-dihydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl]ethanesulfonamide Chemical compound CN1C(=O)CCC2=CC(C3=CN=CC4=C3CCCC4NS(=O)(=O)CC)=CC=C21 LVDKZTHQIJVVBW-UHFFFAOYSA-N 0.000 abstract 1
- VDEUDSRUMNAXJG-UHFFFAOYSA-N n-[4-(1-methyl-2-oxo-3,4-dihydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide Chemical compound CN1C(=O)CCC2=CC(C3=CN=CC4=C3CCCC4NC(=O)CC)=CC=C21 VDEUDSRUMNAXJG-UHFFFAOYSA-N 0.000 abstract 1
- 208000013846 primary aldosteronism Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se refiere compuestos biciclicos derivados de dihidroquinolina-2-ona de formula I en los que R1, R2, R3, R4, R5, R8, R9, R10 son H, alquilo, haloalquilo, cicloalquilo, halocicloalquilo; R6, R7, R12, son H, halogeno, alquilo, haloalquilo, cicloalquilo, entre otros; A1 es N o CR13; A2 es NR14, entre otros; A3 es N o CR17; n es cero, 1 o 2. Dichos compuestos son utiles para terapia o profilaxis de enfermedad renal cronica, fallo cardiaco congestivo, hipertension, aldosteronismo primario, entre otros. Entre los compuestos preferidos tenemos los siguientes: (rac)-N-[4-(1-metil-2-oxo-1,2,3,4-tetrahidro-quinolin-6-il)-5,6,7,8-tetrahidro-isoquinolin-8-il)propionamida; (rac)-N-[4-(1-metil-2-oxo-1,2,3,4-tetrahidroquinolin-6-il)-5,6,7,8-tetrahidroisoquinolin-8-il)etanosulfonamida; entre otros.It refers to bicyclic compounds derived from dihydroquinoline-2-one of formula I in which R1, R2, R3, R4, R5, R8, R9, R10 are H, alkyl, haloalkyl, cycloalkyl, halocycloalkyl; R6, R7, R12, are H, halogen, alkyl, haloalkyl, cycloalkyl, among others; A1 is N or CR13; A2 is NR14, among others; A3 is N or CR17; n is zero, 1 or 2. Said compounds are useful for therapy or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism, among others. Among the preferred compounds we have the following: (rac) -N- [4- (1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl) -5,6,7,8 -tetrahydro-isoquinolin-8-yl) propionamide; (rac) -N- [4- (1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl) -5,6,7,8-tetrahydroisoquinolin-8-yl) ethanesulfonamide; among others.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011080078 | 2011-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181378A1 true PE20181378A1 (en) | 2018-09-05 |
Family
ID=46963698
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000393A PE20141042A1 (en) | 2011-09-23 | 2012-09-20 | NEW BICYCLE DERIVATIVES OF DIHYDROQUINOLINE-2-ONA |
| PE2018001330A PE20181378A1 (en) | 2011-09-23 | 2012-09-20 | DIHYDROQUINOLINE-2-ONA DERIVATIVE BICYCLE COMPOUNDS AS CYP11B INHIBITORS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000393A PE20141042A1 (en) | 2011-09-23 | 2012-09-20 | NEW BICYCLE DERIVATIVES OF DIHYDROQUINOLINE-2-ONA |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9353081B2 (en) |
| EP (1) | EP2758388B1 (en) |
| JP (1) | JP6012737B2 (en) |
| KR (1) | KR101723276B1 (en) |
| CN (1) | CN103827101B (en) |
| AR (1) | AR087984A1 (en) |
| AU (1) | AU2012311582B2 (en) |
| BR (1) | BR112014006660B1 (en) |
| CA (1) | CA2845170C (en) |
| CL (1) | CL2014000663A1 (en) |
| CO (1) | CO6870035A2 (en) |
| CR (1) | CR20140089A (en) |
| DK (1) | DK2758388T3 (en) |
| EA (1) | EA035108B1 (en) |
| EC (1) | ECSP14013264A (en) |
| ES (1) | ES2666802T3 (en) |
| HR (1) | HRP20180592T1 (en) |
| HU (1) | HUE038773T2 (en) |
| IL (1) | IL230874A (en) |
| LT (1) | LT2758388T (en) |
| MX (1) | MX366095B (en) |
| MY (1) | MY186165A (en) |
| NO (1) | NO2758388T3 (en) |
| PE (2) | PE20141042A1 (en) |
| PH (1) | PH12014500584A1 (en) |
| PL (1) | PL2758388T3 (en) |
| PT (1) | PT2758388T (en) |
| RS (1) | RS57139B1 (en) |
| SG (1) | SG2014010599A (en) |
| SI (1) | SI2758388T1 (en) |
| TW (1) | TWI576342B (en) |
| UA (1) | UA115972C2 (en) |
| WO (1) | WO2013041591A1 (en) |
| ZA (1) | ZA201401577B (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117092C2 (en) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Amino-substituted imidazopyridazines |
| KR20150001828A (en) * | 2012-04-17 | 2015-01-06 | 에프. 호프만-라 로슈 아게 | New phenyl-tetrahydroisoquinoline derivatives |
| EP2920176B1 (en) | 2012-11-19 | 2017-09-13 | Bayer Pharma Aktiengesellschaft | Aminoimidazopyridazines as mknk1 kinase inhibitors |
| EP2970198B1 (en) * | 2013-03-14 | 2020-08-05 | F.Hoffmann-La Roche Ag | Dihydroquinoline-2-one derivatives for use as aldosterone synthase inhibitors |
| RS59739B1 (en) * | 2013-05-27 | 2020-02-28 | Hoffmann La Roche | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
| MX368759B (en) * | 2013-05-27 | 2019-10-15 | Hoffmann La Roche | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1- one compounds. |
| EP3004089B1 (en) * | 2013-05-27 | 2020-05-06 | F.Hoffmann-La Roche Ag | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
| JP6484616B2 (en) | 2013-10-17 | 2019-03-13 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthetase |
| EP3057941B1 (en) * | 2013-10-17 | 2019-11-20 | F.Hoffmann-La Roche Ag | New phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors |
| CN105593212B (en) * | 2013-10-17 | 2019-06-04 | 豪夫迈·罗氏有限公司 | Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors |
| EP3212638B1 (en) | 2014-10-31 | 2019-11-20 | F.Hoffmann-La Roche Ag | New dihydroquinoline pyrazolyl compounds as aldosterone synthase inhibitors |
| WO2016066597A1 (en) * | 2014-10-31 | 2016-05-06 | F. Hoffmann-La Roche Ag | New dihydroquinoline pyrazolyl compounds |
| EP3212631B1 (en) * | 2014-10-31 | 2020-02-12 | F.Hoffmann-La Roche Ag | Pyrazolyl-3,4-dihydroquinolin-2-one aldosterone synthase inhibitors |
| WO2016089800A1 (en) * | 2014-12-02 | 2016-06-09 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
| KR20190016971A (en) | 2016-06-10 | 2019-02-19 | 니혼 메디피직스 가부시키가이샤 | Noninvasive diagnostic imaging of heart disease |
| US11958818B2 (en) | 2019-05-01 | 2024-04-16 | Boehringer Ingelheim International Gmbh | (R)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate |
| BR112023027025A2 (en) * | 2021-06-24 | 2024-03-12 | Cincor Pharma Inc | METHODS OF USE OF ALDOSTERONE SYNTHASE INHIBITORS |
| WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| MX2024007335A (en) | 2021-12-14 | 2024-06-26 | Boehringer Ingelheim Int | Aldosterone synthase inhibitors for treating chronic kidney disease. |
| EP4580630A1 (en) | 2022-09-02 | 2025-07-09 | Apnimed, Inc. (Delaware) | Methods and compositions for treating sleep apnea |
| WO2024061371A1 (en) * | 2022-09-23 | 2024-03-28 | 广州威诺森医药科技有限公司 | Annelated pyridine steroid synthetase inhibitor, preparation method therefor, and use thereof |
| EP4624464A1 (en) * | 2022-11-23 | 2025-10-01 | Shanghai Hansoh Biomedical Co., Ltd. | Pyridine polycyclic compound inhibitor, preparation method therefor and use thereof |
| TW202446391A (en) * | 2023-04-28 | 2024-12-01 | 大陸商長春金賽藥業有限責任公司 | Cyp11b2 inhibitor compound, pharmaceutical composition thereof, and use thereof |
| WO2024235165A1 (en) * | 2023-05-12 | 2024-11-21 | 南京明德新药研发有限公司 | Nitrogen-containing heterocyclic compound and use thereof |
| WO2025002335A1 (en) * | 2023-06-29 | 2025-01-02 | 苏州科睿思制药有限公司 | Crystal form of baxdrostat, and preparation method therefor and use thereof |
| TW202504603A (en) * | 2023-07-21 | 2025-02-01 | 大陸商上海翰森生物醫藥科技有限公司 | Tricyclic ring compounds, preparing method thereof, and use thereof |
| WO2025054172A1 (en) | 2023-09-05 | 2025-03-13 | E-Star Biotech, LLC | Formulations of manp and uses thereof |
| CN117247371A (en) * | 2023-09-18 | 2023-12-19 | 上海相辉医药科技有限公司 | Preparation method of CYP11B2 inhibitor BAXDROSTAT |
| TW202519227A (en) * | 2023-11-10 | 2025-05-16 | 大陸商上海齊魯製藥研究中心有限公司 | Condensed ring derivative, preparation method thereof and application thereof in medicine |
| TW202525278A (en) | 2023-12-15 | 2025-07-01 | 愛爾蘭商阿斯特捷利康愛爾蘭有限公司 | Methods of treating chronic kidney disease and hypertension |
| CN120289471B (en) * | 2024-03-01 | 2025-10-17 | 浙江扬厉医药技术有限公司 | Pyranopyridine compound, preparation method thereof, pharmaceutical composition and application |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| GB8709448D0 (en) | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| US5246944A (en) * | 1991-08-13 | 1993-09-21 | Merck & Co., Inc. | Quinoline angiotensin ii antagonists incorporating a substituted benzyl element |
| WO2005065050A2 (en) * | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | Bicyclic compound |
| AU2006326662B2 (en) | 2005-12-09 | 2011-07-28 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
| DE102008022221A1 (en) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitors of human aldosterone synthase CYP11B2 |
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2012
- 2012-09-14 US US13/615,901 patent/US9353081B2/en active Active
- 2012-09-20 DK DK12766628.7T patent/DK2758388T3/en active
- 2012-09-20 MX MX2014002624A patent/MX366095B/en active IP Right Grant
- 2012-09-20 MY MYPI2014700679A patent/MY186165A/en unknown
- 2012-09-20 EP EP12766628.7A patent/EP2758388B1/en active Active
- 2012-09-20 UA UAA201404207A patent/UA115972C2/en unknown
- 2012-09-20 WO PCT/EP2012/068472 patent/WO2013041591A1/en not_active Ceased
- 2012-09-20 KR KR1020147010662A patent/KR101723276B1/en active Active
- 2012-09-20 CA CA2845170A patent/CA2845170C/en active Active
- 2012-09-20 HU HUE12766628A patent/HUE038773T2/en unknown
- 2012-09-20 LT LTEP12766628.7T patent/LT2758388T/en unknown
- 2012-09-20 PE PE2014000393A patent/PE20141042A1/en active IP Right Grant
- 2012-09-20 CN CN201280045785.3A patent/CN103827101B/en active Active
- 2012-09-20 PH PH1/2014/500584A patent/PH12014500584A1/en unknown
- 2012-09-20 PE PE2018001330A patent/PE20181378A1/en unknown
- 2012-09-20 EA EA201490567A patent/EA035108B1/en not_active IP Right Cessation
- 2012-09-20 SI SI201231277T patent/SI2758388T1/en unknown
- 2012-09-20 JP JP2014531214A patent/JP6012737B2/en active Active
- 2012-09-20 RS RS20180446A patent/RS57139B1/en unknown
- 2012-09-20 ES ES12766628.7T patent/ES2666802T3/en active Active
- 2012-09-20 BR BR112014006660-4A patent/BR112014006660B1/en active IP Right Grant
- 2012-09-20 NO NO12766628A patent/NO2758388T3/no unknown
- 2012-09-20 HR HRP20180592TT patent/HRP20180592T1/en unknown
- 2012-09-20 SG SG2014010599A patent/SG2014010599A/en unknown
- 2012-09-20 AU AU2012311582A patent/AU2012311582B2/en active Active
- 2012-09-20 PL PL12766628T patent/PL2758388T3/en unknown
- 2012-09-20 PT PT127666287T patent/PT2758388T/en unknown
- 2012-09-21 TW TW101134790A patent/TWI576342B/en active
- 2012-09-21 AR ARP120103485A patent/AR087984A1/en active IP Right Grant
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2014
- 2014-01-31 CO CO14020664A patent/CO6870035A2/en active IP Right Grant
- 2014-02-06 IL IL230874A patent/IL230874A/en active IP Right Grant
- 2014-02-25 CR CR20140089A patent/CR20140089A/en unknown
- 2014-02-28 ZA ZA2014/01577A patent/ZA201401577B/en unknown
- 2014-03-19 CL CL2014000663A patent/CL2014000663A1/en unknown
- 2014-03-21 EC ECSP14013264 patent/ECSP14013264A/en unknown
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