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PE20180693A1 - Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia contra el cancer epitelial de ovario y otros tipos de cancer - Google Patents

Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia contra el cancer epitelial de ovario y otros tipos de cancer

Info

Publication number
PE20180693A1
PE20180693A1 PE2018000052A PE2018000052A PE20180693A1 PE 20180693 A1 PE20180693 A1 PE 20180693A1 PE 2018000052 A PE2018000052 A PE 2018000052A PE 2018000052 A PE2018000052 A PE 2018000052A PE 20180693 A1 PE20180693 A1 PE 20180693A1
Authority
PE
Peru
Prior art keywords
peptides
cancer
new
lymphocytes
peptide
Prior art date
Application number
PE2018000052A
Other languages
English (en)
Inventor
Hans-Georg Rammensee
Heiko Schuster
Janet Peper
Philipp Wagner
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of PE20180693A1 publication Critical patent/PE20180693A1/es

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    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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Abstract

Esta referido a un peptido que comprende una secuencia de aminoacidos seleccionada entre el grupo consistente en la SEQ ID No. 1 a la SEQ ID No. 549, y secuencias variantes de las mismas que son como minimo homologas en un 88%, y en que dicha variante se une a una o varias moleculas del complejo mayor de histocompatibilidad (MHC) y/o induce la reaccion cruzada de linfocitos T con el peptido variante; estos, tambien pueden ser dianas de anticuerpos, de receptores de linfocitos T solubles, y de otras moleculas de union. Asimismo, los epitopos peptidicos para linfocitos T asociados a tumores, solos o en combinacion con otros peptidos asociados a tumores (TUMAP), pueden servir como principios activos farmaceuticos en composiciones vacunales destinadas a estimular respuestas inmunitarias antitumorales, o a estimular ex vivo linfocitos T que despues seran transferidos a los pacientes. Tambien se refiere a proteinas y celulas destinadas a la utilizacion en metodos inmunoterapeuticos; en particular, a la inmunoterapia contra el cancer
PE2018000052A 2015-07-15 2016-07-14 Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia contra el cancer epitelial de ovario y otros tipos de cancer PE20180693A1 (es)

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