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PE20170302A1 - Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington - Google Patents

Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington

Info

Publication number
PE20170302A1
PE20170302A1 PE2016002253A PE2016002253A PE20170302A1 PE 20170302 A1 PE20170302 A1 PE 20170302A1 PE 2016002253 A PE2016002253 A PE 2016002253A PE 2016002253 A PE2016002253 A PE 2016002253A PE 20170302 A1 PE20170302 A1 PE 20170302A1
Authority
PE
Peru
Prior art keywords
pridopidine
treatment
high doses
huntington disease
huntington
Prior art date
Application number
PE2016002253A
Other languages
English (en)
Inventor
Esther Lukasiewicz Hagai
Merav Bassan
Teige Wickenberg Anna Kristina Sveinsdotter
Eli Eyal
Original Assignee
Teva Pharmaceuticals Int Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52105289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20170302(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceuticals Int Gmbh filed Critical Teva Pharmaceuticals Int Gmbh
Publication of PE20170302A1 publication Critical patent/PE20170302A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se refiere a un metodo de tratamiento de un paciente humano afectado con enfermedad de Huntington que comprende la administracion periodica via oral de una composicion farmaceutica que comprende pridopidina o una sal farmaceuticamente aceptable de la misma, tal como clorhidrato; de tal manera que se administren mas de 135 mg de pridopidina al paciente al dia
PE2016002253A 2013-06-21 2014-06-19 Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington PE20170302A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361837928P 2013-06-21 2013-06-21
US201361877832P 2013-09-13 2013-09-13

Publications (1)

Publication Number Publication Date
PE20170302A1 true PE20170302A1 (es) 2017-03-31

Family

ID=52105289

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2015002618A PE20160195A1 (es) 2013-06-21 2014-06-19 Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington
PE2016002253A PE20170302A1 (es) 2013-06-21 2014-06-19 Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2015002618A PE20160195A1 (es) 2013-06-21 2014-06-19 Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington

Country Status (24)

Country Link
US (1) US10322119B2 (es)
EP (1) EP3010506B1 (es)
JP (1) JP2016523862A (es)
KR (1) KR102316933B1 (es)
CN (1) CN105592848A (es)
AU (1) AU2014281414A1 (es)
BR (1) BR112015029918A2 (es)
CA (1) CA2913781C (es)
CL (1) CL2015003690A1 (es)
DK (1) DK3010506T3 (es)
EA (1) EA201690069A1 (es)
ES (1) ES2879631T3 (es)
HK (1) HK1221646A1 (es)
HU (1) HUE054783T2 (es)
IL (1) IL242804B (es)
MX (1) MX384234B (es)
PE (2) PE20160195A1 (es)
PH (1) PH12015502691A1 (es)
PL (1) PL3010506T3 (es)
SG (1) SG11201509729YA (es)
TW (1) TW201529069A (es)
UA (1) UA122999C2 (es)
UY (1) UY35624A (es)
WO (1) WO2014205229A1 (es)

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USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
PE20140105A1 (es) 2010-09-03 2014-02-14 Ivax Int Gmbh Analogos deuterados de pridopidina utiles como estabilizadores dopaminergicos
WO2013086425A1 (en) 2011-12-08 2013-06-13 IVAX International GmbH The hydrobromide salt of pridopidine
US11090297B2 (en) 2013-06-21 2021-08-17 Prilenia Neurotherapeutics Ltd. Pridopidine for treating huntington's disease
US20150202302A1 (en) * 2014-01-22 2015-07-23 IVAX International GmbH Modified release formulations of pridopidine
TW201613859A (en) 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
EP3236964A4 (en) 2014-12-22 2018-09-19 Teva Pharmaceuticals International GmbH L-tartrate salt of pridopidine
US11471449B2 (en) * 2015-02-25 2022-10-18 Prilenia Neurotherapeutics Ltd. Use of pridopidine to improve cognitive function and for treating Alzheimer's disease
EP4282479A3 (en) * 2015-02-25 2024-02-21 Prilenia Neurotherapeutics Ltd. Use of pridopidine to treat depression or anxiety
AR105434A1 (es) 2015-07-22 2017-10-04 Teva Pharmaceuticals Int Gmbh Proceso para preparar pridopidina
EP3324967A4 (en) * 2015-07-22 2019-03-20 Prilenia Therapeutics Development Ltd. PRIDOPIDINE-BASED FORMULATIONS AND USE OF THE SAME
WO2017147366A1 (en) 2016-02-24 2017-08-31 Teva Pharmaceuticals International Gmbh Treatment of neurodegenerative eye disease using pridopidine
BR112019003731A2 (pt) * 2016-08-24 2019-07-16 Prilenia Therapeutics Dev Ltd aplicação de pridopidina para tratamento de distonias
CA3035092C (en) * 2016-08-24 2022-05-31 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating functional decline
DK3512517T3 (da) 2016-09-15 2025-06-10 Prilenia Neurotherapeutics Ltd Anvendelse af pridopidin til behandling af angst og depression
CA3036984C (en) 2016-09-16 2023-07-18 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating rett syndrome
US12102627B2 (en) 2016-09-16 2024-10-01 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating rett syndrome
EP3570940B1 (en) 2017-01-20 2023-12-13 Prilenia Neurotherapeutics Ltd. Pridopidine for use in the treatment of fragile x syndrome
RS67438B1 (sr) * 2017-08-14 2025-12-31 Prilenia Neurotherapeutics Ltd Lečenje amiotrofne lateralne skleroze pridopidinom
MX2020002310A (es) 2017-08-30 2020-09-17 Prilenia Neurotherapeutics Ltd Formas de dosificacion de alta concentracion de pridopidina.
US12036213B2 (en) 2017-09-08 2024-07-16 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
MX383462B (es) 2017-09-08 2025-03-14 Prilenia Neurotherapeutics Ltd Pridopidina para el tratamiento de las discinesias inducidas por fármacos
CN113365551A (zh) * 2019-01-31 2021-09-07 豪夫迈·罗氏有限公司 评估亨廷顿氏病的进展
CN121489943A (zh) 2019-02-04 2026-02-10 普瑞尼亚神经治疗有限公司 用于帕金森氏病和与帕金森症相关的其它疾病的低剂量普利多匹定
CA3137633A1 (en) * 2019-06-12 2020-12-17 Prilenia Neurotherapeutics Ltd. Composition comprising pridopidine and analog thereof for treating huntington disease and symptoms thereof
EP4030993A4 (en) * 2019-09-17 2023-10-25 F. Hoffmann-La Roche AG Improvements in personalized healthcare for patients with movement disorders
WO2022094565A1 (en) * 2020-10-28 2022-05-05 Buck Institute For Research On Aging N-propargylglycine: a unique inhibitor of proline dehydrogenase with brain-enhancing mitohormesis properties capable of mitigating neurodegenerative disorders
WO2025181805A1 (en) * 2024-02-27 2025-09-04 Prilenia Neurotherapeutics Ltd. Pridopidine and sigma 2 antagonist agent for treating huntington disease and symptoms thereof

Family Cites Families (30)

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Publication number Priority date Publication date Assignee Title
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
EP1713486A4 (en) 2003-12-02 2009-04-29 Sheldon Leslie James COMBINED THERAPY FOR THE TREATMENT OF DEMENTIA, DEPRESSION AND APATHY
ES2659577T3 (es) 2004-10-13 2018-03-16 Teva Pharmaceuticals International Gmbh Proceso para la síntesis de 4-(3-metanosulfonilfenil)-1-N-propil-piperidina
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NZ580856A (en) 2007-04-12 2011-11-25 Nsab Af Neurosearch Sweden Ab N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles
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WO2011107583A1 (en) * 2010-03-04 2011-09-09 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
PE20140105A1 (es) 2010-09-03 2014-02-14 Ivax Int Gmbh Analogos deuterados de pridopidina utiles como estabilizadores dopaminergicos
AU2012306386B2 (en) 2011-09-07 2017-06-15 Teva Pharmaceuticals International Gmbh Polymorphic form of pridopidine hydrochloride
WO2013086425A1 (en) 2011-12-08 2013-06-13 IVAX International GmbH The hydrobromide salt of pridopidine
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
EP2844346B1 (en) 2012-04-04 2020-01-01 Prilenia Neurotherapeutics Ltd. Pharmaceutical compositions for combination therapy
MX2015003608A (es) 2012-09-27 2015-06-05 Teva Pharma Combinacion de laquinimod y pridopidina para tratar trastornos neurodegenerativos.
BR112015006093A2 (pt) 2012-09-27 2017-07-04 Teva Pharma combinação de rasagilina e pridopidine para o tratamento de desordens neurodegenerativas, particularmente na doença de huntington
US20150202302A1 (en) 2014-01-22 2015-07-23 IVAX International GmbH Modified release formulations of pridopidine
TW201613859A (en) 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
EP3236964A4 (en) 2014-12-22 2018-09-19 Teva Pharmaceuticals International GmbH L-tartrate salt of pridopidine
EP4282479A3 (en) 2015-02-25 2024-02-21 Prilenia Neurotherapeutics Ltd. Use of pridopidine to treat depression or anxiety
WO2016138135A1 (en) 2015-02-25 2016-09-01 Teva Pharmaceuticals International Gmbh Sigma-1 receptor modulators for treating huntington's disease
EP3324967A4 (en) 2015-07-22 2019-03-20 Prilenia Therapeutics Development Ltd. PRIDOPIDINE-BASED FORMULATIONS AND USE OF THE SAME
AR105434A1 (es) 2015-07-22 2017-10-04 Teva Pharmaceuticals Int Gmbh Proceso para preparar pridopidina
WO2017048457A1 (en) 2015-09-18 2017-03-23 Teva Pharmaceuticals Industries Ltd. Combination of laquinimod and pridopidine to treat multiple sclerosis
BR112019003731A2 (pt) 2016-08-24 2019-07-16 Prilenia Therapeutics Dev Ltd aplicação de pridopidina para tratamento de distonias
CA3035092C (en) * 2016-08-24 2022-05-31 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating functional decline
DK3512517T3 (da) 2016-09-15 2025-06-10 Prilenia Neurotherapeutics Ltd Anvendelse af pridopidin til behandling af angst og depression
CA3036984C (en) 2016-09-16 2023-07-18 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating rett syndrome
WO2018053275A1 (en) 2016-09-16 2018-03-22 Teva Pharmaceuticals International Gmbh Use of pridopidine for the treatment of familial dysautonomia

Also Published As

Publication number Publication date
EP3010506B1 (en) 2021-05-12
EP3010506A1 (en) 2016-04-27
US10322119B2 (en) 2019-06-18
BR112015029918A2 (pt) 2017-07-25
CA2913781C (en) 2022-05-10
JP2016523862A (ja) 2016-08-12
DK3010506T3 (da) 2021-07-12
US20140378508A1 (en) 2014-12-25
MX384234B (es) 2025-03-14
PH12015502691A1 (en) 2016-03-14
KR20160055122A (ko) 2016-05-17
EP3010506A4 (en) 2017-02-08
WO2014205229A8 (en) 2015-04-09
HUE054783T2 (hu) 2021-09-28
AU2014281414A1 (en) 2016-01-21
ES2879631T3 (es) 2021-11-22
CL2015003690A1 (es) 2016-10-28
WO2014205229A1 (en) 2014-12-24
MX2015017307A (es) 2016-08-03
CA2913781A1 (en) 2014-12-24
PL3010506T3 (pl) 2021-11-02
PE20160195A1 (es) 2016-05-14
UY35624A (es) 2015-01-30
IL242804B (en) 2022-02-01
TW201529069A (zh) 2015-08-01
EA201690069A1 (ru) 2016-06-30
KR102316933B1 (ko) 2021-10-26
SG11201509729YA (en) 2015-12-30
CN105592848A (zh) 2016-05-18
UA122999C2 (uk) 2021-02-03
HK1221646A1 (zh) 2017-06-09

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