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PE20161440A1 - Variantes del anticuerpo anti-factor d y sus usos - Google Patents

Variantes del anticuerpo anti-factor d y sus usos

Info

Publication number
PE20161440A1
PE20161440A1 PE2016002153A PE2016002153A PE20161440A1 PE 20161440 A1 PE20161440 A1 PE 20161440A1 PE 2016002153 A PE2016002153 A PE 2016002153A PE 2016002153 A PE2016002153 A PE 2016002153A PE 20161440 A1 PE20161440 A1 PE 20161440A1
Authority
PE
Peru
Prior art keywords
seq
factor
amino acid
hvr
antibody
Prior art date
Application number
PE2016002153A
Other languages
English (en)
Inventor
Devin Tesar
Philip E Hass
Robert F Kelley
Lookeren-Campagne Menno Van
Justin M Scheer
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20161440A1 publication Critical patent/PE20161440A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21046—Complement factor D (3.4.21.46)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se refiere a una variante del anticuerpo anti-factor D con mejor estabilidad y sin perdida significativa de la afinidad de union del factor D cuando se compara con el anticuerpo anti-factor D de referencia, esta variante comprende la sustitucion de al menos un residuo de acido aspartico blanco (D o Asp) dentro de una region hipervariable de un anticuerpo anti-factor D de referencia, donde dicho residuo es propenso a la isomerizacion y la sustitucion es Asp a Acido glutamico (E o Glu). El anticuerpo anti-factor D de referencia comprende regiones hipervariables livianas HVR-1 de SEQ ID NO: 5, HVR-2 de SEQ ID NO: 6, HVR-3 de SEQ ID NO 7 y regiones hipervariables pesadas HVR-1 de SEQ ID NO: 8, HVR-2 de SEQ ID NO:9, HVR-3 de SEQ ID NO:10, y donde dicha sustitucion es: a) aminoacido en la posicion 5 de la SEQ ID NO: 5 es S, b) aminoacido en la posicion 7 de la SEQ ID NO: 5 es E, c) aminoacido en la posicion 8 de la SEQ ID NO: 5 es S, d) aminoacido en la posicion 13 de la SEQ ID NO: 9 es E, e) aminoacido en la posicion 4 de la SEQ ID NO:7 es E o f) aminoacido en la posicion 5 de la SEQ ID NO: 10 es S. Tambien se refiere a un metodo, una formulacion farmaceutica y un dispositivo de administracion. Dichas variantes de anticuerpos son utiles en el tratamiento de enfermedades oculares tales como degeneracion macular relacionada con la edad, retinopatia diabetica, entre otras
PE2016002153A 2014-05-01 2015-04-30 Variantes del anticuerpo anti-factor d y sus usos PE20161440A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461987298P 2014-05-01 2014-05-01
US201462076372P 2014-11-06 2014-11-06

Publications (1)

Publication Number Publication Date
PE20161440A1 true PE20161440A1 (es) 2017-01-26

Family

ID=53059539

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016002153A PE20161440A1 (es) 2014-05-01 2015-04-30 Variantes del anticuerpo anti-factor d y sus usos

Country Status (19)

Country Link
US (1) US10179821B2 (es)
EP (1) EP3137503A1 (es)
JP (1) JP2017515811A (es)
KR (1) KR20160147855A (es)
CN (1) CN106536561A (es)
AU (1) AU2015253042A1 (es)
BR (1) BR112016025312A2 (es)
CA (1) CA2944712A1 (es)
CL (1) CL2016002738A1 (es)
CR (1) CR20160561A (es)
EA (1) EA201692109A1 (es)
IL (1) IL248042A0 (es)
MA (1) MA39934A (es)
MX (1) MX2016014160A (es)
PE (1) PE20161440A1 (es)
PH (1) PH12016502015A1 (es)
SG (1) SG11201608868PA (es)
TW (1) TW201623337A (es)
WO (1) WO2015168468A1 (es)

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