PE20161408A1 - Composiciones de insulina de rapida accion - Google Patents
Composiciones de insulina de rapida accionInfo
- Publication number
- PE20161408A1 PE20161408A1 PE2016002179A PE2016002179A PE20161408A1 PE 20161408 A1 PE20161408 A1 PE 20161408A1 PE 2016002179 A PE2016002179 A PE 2016002179A PE 2016002179 A PE2016002179 A PE 2016002179A PE 20161408 A1 PE20161408 A1 PE 20161408A1
- Authority
- PE
- Peru
- Prior art keywords
- insulin
- acting insulin
- fast acting
- insulin compositions
- treprostinil
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se refiere a una composicion farmaceutica que comprende: a) insulina tal como insulina humana, insulina lispro, insulina aspartica e insulina glulisina; a una concentracion de 40 UI/mL a 500 UI/mL; b) treprostinilo en una concentracion de 0,01 uM a 30 uM; c) conservantes tal como fenol, meta-cresol y alcohol bencilico; d) un agente de tonicidad tal como glicerol o cloruro de sodio; e) un agente estabilizante tal como zinc, cloruro de sodio, cloruro de calcio y arginina; y f) un agente amortiguador. Es una composicion preferida: insulina lispro de 40 UI/mL a 500 UI/mL; treprostinilo de 0,01 uM a 30 uM; meta-cresol de 2,5 mg/mL a 3,8 mg/mL; glicerol de 5 mg/mL a 20 mg/mL; zinc de 0,00525 mg/mL a 0,131 mg/mL y pH de 7,0 a 7,8. Tambien se refiere a un metodo de tratamiento. Dicha composicion es util en el tratamiento de la diabetes
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461990402P | 2014-05-08 | 2014-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20161408A1 true PE20161408A1 (es) | 2016-12-28 |
Family
ID=53189204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016002179A PE20161408A1 (es) | 2014-05-08 | 2015-05-04 | Composiciones de insulina de rapida accion |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US9439952B2 (es) |
| EP (3) | EP3536380B8 (es) |
| JP (1) | JP6050902B2 (es) |
| KR (1) | KR101858890B1 (es) |
| CN (1) | CN106456717B (es) |
| AP (1) | AP2016009525A0 (es) |
| AR (1) | AR100155A1 (es) |
| AU (1) | AU2015256355B2 (es) |
| BR (1) | BR112016024357B1 (es) |
| CA (1) | CA2945188C (es) |
| CL (1) | CL2016002772A1 (es) |
| CY (2) | CY1121669T1 (es) |
| DK (2) | DK3536380T3 (es) |
| EA (1) | EA031134B1 (es) |
| ES (2) | ES2891983T3 (es) |
| HR (2) | HRP20190777T1 (es) |
| HU (2) | HUE044370T2 (es) |
| IL (1) | IL248350B (es) |
| JO (1) | JO3624B1 (es) |
| LT (2) | LT3140008T (es) |
| MA (1) | MA39441A1 (es) |
| ME (1) | ME03384B (es) |
| MX (1) | MX367521B (es) |
| NZ (1) | NZ724919A (es) |
| PE (1) | PE20161408A1 (es) |
| PH (1) | PH12016502195A1 (es) |
| PL (2) | PL3140008T3 (es) |
| PT (2) | PT3140008T (es) |
| RS (2) | RS62291B1 (es) |
| SG (1) | SG11201608424WA (es) |
| SI (2) | SI3140008T1 (es) |
| TN (1) | TN2016000443A1 (es) |
| TR (1) | TR201906843T4 (es) |
| TW (1) | TWI685348B (es) |
| UA (1) | UA124919C2 (es) |
| WO (1) | WO2015171484A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5749155B2 (ja) | 2008-03-18 | 2015-07-15 | ノボ・ノルデイスク・エー／エス | プロテアーゼ安定化アシル化インスリンアナログ |
| JP6322642B2 (ja) | 2012-11-13 | 2018-05-09 | アドシア | 置換されたアニオン性化合物を含有する速効型インスリン製剤 |
| ES2805367T3 (es) | 2013-01-11 | 2021-02-11 | Corsair Pharma Inc | Profármacos de treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| WO2017015760A1 (en) * | 2015-07-28 | 2017-02-02 | Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines, S.E.C. | A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| CA3199504A1 (en) * | 2016-01-29 | 2017-08-03 | Mannkind Corporation | Dry powder inhaler |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| CN110678174A (zh) | 2016-09-26 | 2020-01-10 | 联合治疗学有限公司 | 曲前列环素的前药 |
| IL265609B2 (en) | 2016-09-29 | 2024-02-01 | Arecor Ltd | An aqueous pharmaceutical preparation containing insulin, ionic zinc and a non-ionic surfactant and a medical device containing this preparation |
| HUE060149T2 (hu) | 2016-12-16 | 2023-02-28 | Novo Nordisk As | Inzulint tartalmazó gyógyászati készítmények |
| GB201707187D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| GB201707189D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| GB201707188D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| IL270975B2 (en) | 2017-06-01 | 2024-02-01 | Lilly Co Eli | Fast-acting insulin preparations |
| IL277731B2 (en) | 2018-04-04 | 2024-03-01 | Arecor Ltd | Medical infusion pump system for the delivery of an insulin compound |
| EP3773473A1 (en) | 2018-04-04 | 2021-02-17 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| WO2019193353A1 (en) | 2018-04-04 | 2019-10-10 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| FR3083985A1 (fr) | 2018-07-23 | 2020-01-24 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| WO2019243627A1 (fr) | 2018-06-23 | 2019-12-26 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| KR102659451B1 (ko) * | 2018-09-18 | 2024-04-23 | 일라이 릴리 앤드 캄파니 | 트레프로스티닐의 에르부민 염 |
| US10799564B1 (en) * | 2019-05-06 | 2020-10-13 | Baxter International Inc. | Insulin premix formulation and product, methods of preparing same, and methods of using same |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
| CN114616225A (zh) | 2019-08-23 | 2022-06-10 | 联合治疗公司 | 曲前列环素前药 |
| GB202004814D0 (en) | 2020-04-01 | 2020-05-13 | Arecor Ltd | Novel formulations |
| EP4135707A1 (en) | 2020-04-17 | 2023-02-22 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
| US11793780B2 (en) | 2020-06-09 | 2023-10-24 | United Therapeutics Corporation | Prodrugs of treprosiinil |
| CN115697379A (zh) * | 2020-06-30 | 2023-02-03 | 江苏恒瑞医药股份有限公司 | 速效胰岛素组合物及其医药用途 |
| CN117062605A (zh) | 2020-12-14 | 2023-11-14 | 联合治疗公司 | 使用曲前列环素前药治疗疾病的方法 |
| KR20240012354A (ko) | 2021-03-03 | 2024-01-29 | 유나이티드 쎄러퓨틱스 코포레이션 | (e)-3,6-비스[4-(n-카보닐-2-프로페닐)아미도부틸]-2,5-디케토피페라진(fdkp)을 추가로 포함하는, 트레프로스티닐 및 이의 프로드러그의 건조 분말 조성물 |
| KR20250002687A (ko) * | 2022-04-29 | 2025-01-07 | 자오커 파마슈티컬 (광저우) 컴퍼니., 리미티드 | 트레프로스티닐 소프트 미스트 흡입제 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE2740953A1 (de) | 1977-09-12 | 1979-03-22 | Thera Ges Fuer Patente | Verwendung von prostaglandinen zur senkung des blutzuckerspiegels |
| JPH10251146A (ja) * | 1997-03-11 | 1998-09-22 | Toray Ind Inc | 糖尿病性神経障害の治療方法 |
| US7238663B2 (en) * | 2001-08-28 | 2007-07-03 | Eli Lilly And Company | Pre-mixes of GLP-1 and basal insulin |
| EP1506230B1 (en) * | 2002-05-07 | 2011-01-19 | Novo Nordisk A/S | Soluble formulations comprising monomeric insulin and acylated insulin |
| JP2007532663A (ja) * | 2004-04-12 | 2007-11-15 | ユナイテッド セラピューティクス インコーポレイテッド | ニューロパシー性の糖尿病性足潰瘍を治療するためのトレプロスチニルの使用 |
| EP2190433A2 (en) * | 2007-08-22 | 2010-06-02 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
| EP2328636B1 (en) | 2008-08-28 | 2013-06-12 | Medingo Ltd. | Device for enhanced subcutaneous insulin absorption |
| KR20110081204A (ko) * | 2008-09-25 | 2011-07-13 | 아라다임 코포레이션 | 트레프로스티닐의 폐 심부 전달 |
| KR101775000B1 (ko) | 2009-06-26 | 2017-09-04 | 노보 노르디스크 에이/에스 | 인슐린, 니코틴아미드 및 아미노산을 포함하는 제제 |
| KR101701943B1 (ko) * | 2009-11-13 | 2017-02-02 | 도레이 카부시키가이샤 | 당뇨병의 치료 또는 예방약 |
| CN103328006A (zh) | 2010-12-14 | 2013-09-25 | 诺沃—诺迪斯克有限公司 | 包含胰岛素、烟酰胺和氨基酸的制剂 |
| JP6092867B2 (ja) * | 2011-08-12 | 2017-03-08 | アセンディス ファーマ エー／エス | 担体連結しているトレプロスチニルプロドラッグ |
| US9381247B2 (en) * | 2012-04-16 | 2016-07-05 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
| US20150065423A1 (en) | 2013-08-30 | 2015-03-05 | Perosphere, Inc. | Rapid acting injectable formulations |
| US20150273022A1 (en) | 2014-02-10 | 2015-10-01 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
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2015
- 2015-04-21 TW TW104112752A patent/TWI685348B/zh active
- 2015-04-21 JO JOP/2015/0079A patent/JO3624B1/ar active
- 2015-04-22 AR ARP150101208A patent/AR100155A1/es not_active Application Discontinuation
- 2015-05-04 ES ES19161129T patent/ES2891983T3/es active Active
- 2015-05-04 MX MX2016014643A patent/MX367521B/es active IP Right Grant
- 2015-05-04 SG SG11201608424WA patent/SG11201608424WA/en unknown
- 2015-05-04 PL PL15723388T patent/PL3140008T3/pl unknown
- 2015-05-04 EA EA201691911A patent/EA031134B1/ru active Protection Beyond IP Right Term
- 2015-05-04 DK DK19161129.2T patent/DK3536380T3/da active
- 2015-05-04 HR HRP20190777TT patent/HRP20190777T1/hr unknown
- 2015-05-04 US US14/781,342 patent/US9439952B2/en active Active
- 2015-05-04 MA MA39441A patent/MA39441A1/fr unknown
- 2015-05-04 EP EP19161129.2A patent/EP3536380B8/en active Active
- 2015-05-04 EP EP21183262.1A patent/EP3943155A1/en not_active Withdrawn
- 2015-05-04 BR BR112016024357-9A patent/BR112016024357B1/pt active IP Right Grant
- 2015-05-04 PT PT15723388T patent/PT3140008T/pt unknown
- 2015-05-04 HU HUE15723388 patent/HUE044370T2/hu unknown
- 2015-05-04 NZ NZ724919A patent/NZ724919A/en unknown
- 2015-05-04 TN TN2016000443A patent/TN2016000443A1/en unknown
- 2015-05-04 PE PE2016002179A patent/PE20161408A1/es unknown
- 2015-05-04 ES ES15723388T patent/ES2733639T3/es active Active
- 2015-05-04 SI SI201530716T patent/SI3140008T1/sl unknown
- 2015-05-04 AP AP2016009525A patent/AP2016009525A0/en unknown
- 2015-05-04 ME MEP-2019-126A patent/ME03384B/me unknown
- 2015-05-04 PL PL19161129T patent/PL3536380T3/pl unknown
- 2015-05-04 PT PT191611292T patent/PT3536380T/pt unknown
- 2015-05-04 TR TR2019/06843T patent/TR201906843T4/tr unknown
- 2015-05-04 DK DK15723388.3T patent/DK3140008T3/da active
- 2015-05-04 CN CN201580024110.4A patent/CN106456717B/zh active Active
- 2015-05-04 RS RS20211085A patent/RS62291B1/sr unknown
- 2015-05-04 CA CA2945188A patent/CA2945188C/en active Active
- 2015-05-04 AU AU2015256355A patent/AU2015256355B2/en active Active
- 2015-05-04 EP EP15723388.3A patent/EP3140008B1/en active Active
- 2015-05-04 KR KR1020167031043A patent/KR101858890B1/ko active Active
- 2015-05-04 SI SI201531655T patent/SI3536380T1/sl unknown
- 2015-05-04 UA UAA201611280A patent/UA124919C2/uk unknown
- 2015-05-04 LT LTEP15723388.3T patent/LT3140008T/lt unknown
- 2015-05-04 HU HUE19161129A patent/HUE055742T2/hu unknown
- 2015-05-04 WO PCT/US2015/029010 patent/WO2015171484A1/en not_active Ceased
- 2015-05-04 JP JP2015563152A patent/JP6050902B2/ja active Active
- 2015-05-04 LT LTEP19161129.2T patent/LT3536380T/lt unknown
- 2015-05-04 RS RS20190582A patent/RS58726B1/sr unknown
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2016
- 2016-09-08 US US15/259,101 patent/US10172922B2/en active Active
- 2016-10-13 IL IL248350A patent/IL248350B/en active IP Right Grant
- 2016-11-02 CL CL2016002772A patent/CL2016002772A1/es unknown
- 2016-11-04 PH PH12016502195A patent/PH12016502195A1/en unknown
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2019
- 2019-05-31 CY CY20191100581T patent/CY1121669T1/el unknown
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2021
- 2021-08-20 CY CY20211100747T patent/CY1124454T1/el unknown
- 2021-09-07 HR HRP20211415TT patent/HRP20211415T1/hr unknown
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