PE20160522A1 - Tilmicosina de accion prolongada mejorada de la misma en el tratamiento del complejo respiratorio bovino (crb) y en el periodo de la vaca seca - Google Patents
Tilmicosina de accion prolongada mejorada de la misma en el tratamiento del complejo respiratorio bovino (crb) y en el periodo de la vaca secaInfo
- Publication number
- PE20160522A1 PE20160522A1 PE2015002390A PE2015002390A PE20160522A1 PE 20160522 A1 PE20160522 A1 PE 20160522A1 PE 2015002390 A PE2015002390 A PE 2015002390A PE 2015002390 A PE2015002390 A PE 2015002390A PE 20160522 A1 PE20160522 A1 PE 20160522A1
- Authority
- PE
- Peru
- Prior art keywords
- acting
- improved long
- thilmicosin
- crb
- treatment
- Prior art date
Links
- 241000283690 Bos taurus Species 0.000 title 2
- 230000000241 respiratory effect Effects 0.000 title 1
- 239000006184 cosolvent Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- JTSDBFGMPLKDCD-XVFHVFLVSA-N tilmicosin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C[C@H](C)C[C@H](C)C1)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O JTSDBFGMPLKDCD-XVFHVFLVSA-N 0.000 abstract 2
- 229960000223 tilmicosin Drugs 0.000 abstract 2
- NESIVXZOSKKUDP-ARVJLQODSA-N (4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3s,5r)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13 Chemical compound OP(O)(O)=O.O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C[C@H](C)C[C@H](C)C1)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O NESIVXZOSKKUDP-ARVJLQODSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 125000005909 ethyl alcohol group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229960000757 tilmicosin phosphate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describe una formulacion de tilmicosina de accion o liberacion prolongada mejorada que comprende: fosfato de tilmicosina en una concentracion que va de 35 a 50% en peso de la composicion total; un primer co-solvente en una concentracion que va de 8 a 20% en volumen, en donde dicho primer co-solvente es propilenglicol; un segundo co-solvente en una concentracion que va de 5 a 15% en volumen, en donde dicho segundo co-solvente es alcohol etilico; y, un emulsificante una concentracion de 1.5 a 15 % en peso del total de la composicion, en donde dicho emulsificante es polxamero. Asimismo, se describe el metodo de obtencion de dicha formulacion de tilmicosina de accion prolongada mejorada
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2014001907A MX364800B (es) | 2014-02-18 | 2014-02-18 | Tilmicosina de accion prolongada mejorada y el uso de la misma en el tratamiento del complejo respiratorio bovino (crb) y en el periodo de la vaca seca. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160522A1 true PE20160522A1 (es) | 2016-06-09 |
Family
ID=53878632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002390A PE20160522A1 (es) | 2014-02-18 | 2015-02-18 | Tilmicosina de accion prolongada mejorada de la misma en el tratamiento del complejo respiratorio bovino (crb) y en el periodo de la vaca seca |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20160367580A1 (es) |
| MX (1) | MX364800B (es) |
| PE (1) | PE20160522A1 (es) |
| WO (1) | WO2015126233A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176680A (zh) * | 2016-08-17 | 2016-12-07 | 广州格雷特生物科技有限公司 | 一种肠溶替米考星缓释微囊及其制备方法 |
| CN107308110B (zh) * | 2017-06-14 | 2020-07-07 | 王荻 | 一种替米考星无水胶束溶液及其制备方法 |
| CN107375316B (zh) * | 2017-06-29 | 2020-08-04 | 南京农业大学 | 一种结构脂质载体的制备方法及结构脂质载体 |
| CN107375247B (zh) * | 2017-08-25 | 2020-05-26 | 重庆市畜牧科学院 | 替米考星膜控肠溶缓释制剂及其制备方法 |
| CN109985019B (zh) * | 2017-12-29 | 2021-05-11 | 瑞普（天津）生物药业有限公司 | 一种可控释放的替米考星肠溶微囊及其制备方法 |
| CN108042491B (zh) * | 2018-01-23 | 2021-02-09 | 山东迅达康兽药有限公司 | 一种替米考星纳米乳及其制备方法 |
| CN108653205B (zh) * | 2018-07-26 | 2021-02-26 | 日照市牧邦畜牧科技有限公司 | 一种稳定长效复方替米考星溶液 |
| CN112535664A (zh) * | 2019-09-23 | 2021-03-23 | 江西邦诚动物药业有限公司 | 一种水溶性替米考星预混剂及其制备方法 |
| CN115626941B (zh) * | 2022-12-20 | 2023-07-21 | 山东久隆恒信药业有限公司 | 一种磷酸替米考星的合成方法 |
| CN118178336A (zh) * | 2024-04-03 | 2024-06-14 | 上海同仁药业股份有限公司 | 一种制备高效替米考星预混剂的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946137B2 (en) * | 2001-10-19 | 2005-09-20 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
| US7282487B2 (en) * | 2004-10-28 | 2007-10-16 | Idexx Laboratories | Method for treating bacterial infections in horses or pigs with tilmicosin |
| WO2008030469A2 (en) * | 2006-09-07 | 2008-03-13 | Merial Limited | Soft chewable, tablet, and long-acting injectable veterinary antibiotic formulations |
| CN101422432B (zh) * | 2008-07-09 | 2011-04-27 | 西北农林科技大学 | 一种替米考星纳米乳抗菌药物的制备方法 |
| CN101703776B (zh) * | 2009-09-28 | 2012-07-11 | 洛阳惠中兽药有限公司 | 一种抗感染剂长效注射液的制备方法 |
-
2014
- 2014-02-18 MX MX2014001907A patent/MX364800B/es active IP Right Grant
-
2015
- 2015-02-18 US US14/890,827 patent/US20160367580A1/en not_active Abandoned
- 2015-02-18 WO PCT/MX2015/000031 patent/WO2015126233A1/es not_active Ceased
- 2015-02-18 PE PE2015002390A patent/PE20160522A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015126233A1 (es) | 2015-08-27 |
| US20160367580A1 (en) | 2016-12-22 |
| MX364800B (es) | 2019-04-26 |
| MX2014001907A (es) | 2015-08-18 |
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