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PE20151145A1 - Piridopirazinas sustituidas como inhibidores de syk - Google Patents

Piridopirazinas sustituidas como inhibidores de syk

Info

Publication number
PE20151145A1
PE20151145A1 PE2015000743A PE2015000743A PE20151145A1 PE 20151145 A1 PE20151145 A1 PE 20151145A1 PE 2015000743 A PE2015000743 A PE 2015000743A PE 2015000743 A PE2015000743 A PE 2015000743A PE 20151145 A1 PE20151145 A1 PE 20151145A1
Authority
PE
Peru
Prior art keywords
pyridopyrazines
substituted
syk inhibitors
syk
inhibitors
Prior art date
Application number
PE2015000743A
Other languages
English (en)
Inventor
Wei-Guo Su
Wei Deng
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50882786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20151145(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of PE20151145A1 publication Critical patent/PE20151145A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

La presente invencion se refiere a compuestos con actividad sobre la quinasa SYK derivados de piridopirazina de formula (I) composiciones farmaceuticas de los mismos, en donde R1, R2, R3, L, m, p y W son como se definen en la especificacion
PE2015000743A 2012-12-07 2013-12-06 Piridopirazinas sustituidas como inhibidores de syk PE20151145A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/086144 WO2014086032A1 (en) 2012-12-07 2012-12-07 Substituted pyridopyrazines as syk inhibitors

Publications (1)

Publication Number Publication Date
PE20151145A1 true PE20151145A1 (es) 2015-08-03

Family

ID=50882786

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015000743A PE20151145A1 (es) 2012-12-07 2013-12-06 Piridopirazinas sustituidas como inhibidores de syk

Country Status (17)

Country Link
US (2) US20150307491A1 (es)
EP (1) EP2928888A4 (es)
JP (1) JP6105745B2 (es)
KR (1) KR20150091169A (es)
AU (1) AU2013354552B2 (es)
BR (1) BR112015012825A2 (es)
CA (1) CA2891725A1 (es)
CL (1) CL2015001516A1 (es)
EA (1) EA201590787A1 (es)
HK (1) HK1210178A1 (es)
IL (1) IL239153A0 (es)
MX (1) MX2015007126A (es)
PE (1) PE20151145A1 (es)
PH (1) PH12015501175A1 (es)
SG (1) SG11201503848UA (es)
TW (1) TW201422616A (es)
WO (2) WO2014086032A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10251565B2 (en) * 2015-04-30 2019-04-09 Dna Medicine Institute, Inc. Multi-channel vitals device
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
CA3036384A1 (en) 2016-09-14 2018-03-22 Gilead Sciences, Inc. Syk inhibitors
WO2018195471A1 (en) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Syk inhibitors in combination with hypomethylating agents
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
WO2021080551A1 (en) 2019-10-21 2021-04-29 Devarasetty Pratyush Pavan Systems, devices, and methods for detecting physical distress in infant tracheostomy patients
WO2021089395A1 (en) 2019-11-08 2021-05-14 Nerviano Medical Sciences S.R.L. Gem-disubstituted heterocyclic compounds and their use as idh inhibitors
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
JP2025511779A (ja) * 2022-04-07 2025-04-16 ユニクエスト ピーティーワイ リミテッド 脾臓チロシンキナーゼ阻害剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101115479A (zh) * 2005-02-14 2008-01-30 默克公司 Akt活性抑制剂
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
US8604049B2 (en) * 2008-08-05 2013-12-10 Boehringer Ingelheim International Gmbh 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments
US20110201608A1 (en) * 2008-08-05 2011-08-18 Boehringer Ingelheim International Gmbh Substituted naphthyridines and use thereof as medicines
EP2459558A2 (en) * 2009-07-30 2012-06-06 Irm Llc Compounds and compositions as syk kinase inhibitors
EA201201052A1 (ru) * 2010-01-29 2013-02-28 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные нафтиридины и их применение в качестве ингибиторов киназы syk
WO2012123312A1 (en) * 2011-03-11 2012-09-20 Glaxo Group Limited Pyrido[3,4-b]pyrazine derivatives as syk inhibitors
WO2012167423A1 (en) * 2011-06-08 2012-12-13 Hutchison Medipharma Limited Substituted pyridopyrazines as novel syk inhibitors

Also Published As

Publication number Publication date
MX2015007126A (es) 2015-10-14
WO2014086032A1 (en) 2014-06-12
EP2928888A4 (en) 2016-04-20
US20170152258A9 (en) 2017-06-01
IL239153A0 (en) 2015-07-30
JP6105745B2 (ja) 2017-03-29
US20150307491A1 (en) 2015-10-29
US20160002221A1 (en) 2016-01-07
KR20150091169A (ko) 2015-08-07
AU2013354552A1 (en) 2015-07-23
SG11201503848UA (en) 2015-06-29
BR112015012825A2 (pt) 2017-07-11
TW201422616A (zh) 2014-06-16
WO2014086316A1 (en) 2014-06-12
EA201590787A1 (ru) 2015-11-30
EP2928888A1 (en) 2015-10-14
HK1210178A1 (en) 2016-04-15
JP2016501237A (ja) 2016-01-18
CL2015001516A1 (es) 2015-10-23
PH12015501175A1 (en) 2015-08-17
CA2891725A1 (en) 2014-06-12
AU2013354552B2 (en) 2016-09-29

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