PE20151092A1 - Compuestos derivados de quinolina y quinoxalina como agentes antivirales - Google Patents
Compuestos derivados de quinolina y quinoxalina como agentes antiviralesInfo
- Publication number
- PE20151092A1 PE20151092A1 PE2015001204A PE2015001204A PE20151092A1 PE 20151092 A1 PE20151092 A1 PE 20151092A1 PE 2015001204 A PE2015001204 A PE 2015001204A PE 2015001204 A PE2015001204 A PE 2015001204A PE 20151092 A1 PE20151092 A1 PE 20151092A1
- Authority
- PE
- Peru
- Prior art keywords
- dihydro
- methoxy
- tert
- butyl
- quinoxaline
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 title 2
- 239000003443 antiviral agent Substances 0.000 title 1
- VBBNOSRXGVGKLE-UHFFFAOYSA-N 2-[6-tert-butyl-5-methoxy-8-(2-oxo-1h-pyridin-3-yl)quinolin-3-yl]benzoic acid Chemical compound C12=NC=C(C=3C(=CC=CC=3)C(O)=O)C=C2C(OC)=C(C(C)(C)C)C=C1C1=CC=CNC1=O VBBNOSRXGVGKLE-UHFFFAOYSA-N 0.000 abstract 1
- VYFLZTVXPVTQDD-UHFFFAOYSA-N n-[4-[6-tert-butyl-2-methoxy-3-(2-oxo-1h-pyridin-3-yl)quinolin-8-yl]phenyl]methanesulfonamide Chemical compound COC1=NC2=C(C=3C=CC(NS(C)(=O)=O)=CC=3)C=C(C(C)(C)C)C=C2C=C1C1=CC=CNC1=O VYFLZTVXPVTQDD-UHFFFAOYSA-N 0.000 abstract 1
- KGISHOZEUVOVTB-UHFFFAOYSA-N n-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1h-pyridin-3-yl)quinolin-3-yl]phenyl]methanesulfonamide Chemical compound O=C1NC(OC)=CC=C1C1=CC(C(C)(C)C)=C(OC)C2=CC(C=3C=CC(NS(C)(=O)=O)=CC=3)=CN=C12 KGISHOZEUVOVTB-UHFFFAOYSA-N 0.000 abstract 1
- KDJNKCFVCQPGNF-UHFFFAOYSA-N n-[4-[6-tert-butyl-8-(2,4-dioxopyrimidin-1-yl)-5-methoxyquinolin-3-yl]phenyl]methanesulfonamide Chemical compound C12=NC=C(C=3C=CC(NS(C)(=O)=O)=CC=3)C=C2C(OC)=C(C(C)(C)C)C=C1N1C=CC(=O)NC1=O KDJNKCFVCQPGNF-UHFFFAOYSA-N 0.000 abstract 1
- IFTUXRMJLDMGDN-UHFFFAOYSA-N n-[4-[7-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-3-methylquinoxalin-2-yl]-3-chlorophenyl]methanesulfonamide Chemical compound CC1=NC2=C(N3C(NC(=O)C=C3)=O)C=C(C(C)(C)C)C=C2N=C1C1=CC=C(NS(C)(=O)=O)C=C1Cl IFTUXRMJLDMGDN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
Referida a compuestos especificos tales como N-{4-[6-tert-butil-2-metoxi-3-(2-oxo-1,2-dihidro-piridin-3-il) -quinolin-8-il] -fenil} -metanosulfonamida; N-{4-[6-tert-butil-8- (2,4-dioxo-3,4-dihidro-2H-pirimidin-1-il)-5-metoxi-quinolin-3-il]-fenil} -metanosulfonamida; N-{4-[6-tert-butil-5-metoxi-8-(6-metoxi-2-oxo-1,2-dihidro-piridin-3-il)-quinolin-3-il]-fenil} -metanosulfonamida; acido 2-[6-tert-butil-5-metoxi-8-(2-oxo-1,2-dihidro-piridin-3-il)-quinolin-3-il]-benzoico; N-{4-[7-tert-butil-5-(2,4-dioxo-3,4-dihidro-2H-pirimidin-1-il)-3-metil-quinoxalin-2-il]-3-cloro-fenil}-metano-sulfonamida; entre otros
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18546009P | 2009-06-09 | 2009-06-09 | |
| US26335109P | 2009-11-21 | 2009-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20151092A1 true PE20151092A1 (es) | 2015-08-06 |
Family
ID=42288900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011002042A PE20120937A1 (es) | 2009-06-09 | 2010-06-08 | Compuestos derivados de quinolina y quinoxalina como agentes antivirales |
| PE2015001204A PE20151092A1 (es) | 2009-06-09 | 2010-06-08 | Compuestos derivados de quinolina y quinoxalina como agentes antivirales |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011002042A PE20120937A1 (es) | 2009-06-09 | 2010-06-08 | Compuestos derivados de quinolina y quinoxalina como agentes antivirales |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8026253B2 (es) |
| EP (1) | EP2440528B1 (es) |
| JP (1) | JP5612678B2 (es) |
| KR (1) | KR101431343B1 (es) |
| CN (1) | CN102803216B (es) |
| AR (1) | AR077004A1 (es) |
| AU (1) | AU2010257592B2 (es) |
| BR (1) | BRPI1010852A2 (es) |
| CA (1) | CA2764141C (es) |
| CO (1) | CO6400218A2 (es) |
| CR (1) | CR20110605A (es) |
| EC (1) | ECSP11011513A (es) |
| ES (1) | ES2525254T3 (es) |
| IL (1) | IL216412A (es) |
| MA (1) | MA33360B1 (es) |
| MX (1) | MX2011013209A (es) |
| MY (1) | MY157435A (es) |
| NZ (1) | NZ596646A (es) |
| PE (2) | PE20120937A1 (es) |
| RU (1) | RU2540332C2 (es) |
| SG (1) | SG176762A1 (es) |
| TW (1) | TWI428332B (es) |
| WO (1) | WO2010142656A1 (es) |
| ZA (1) | ZA201108921B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG174252A1 (en) * | 2009-03-06 | 2011-10-28 | Hoffmann La Roche | Heterocyclic antiviral compounds |
| ES2481411T3 (es) * | 2010-07-07 | 2014-07-30 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
| BR112013003113A2 (pt) * | 2010-08-13 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| WO2013090929A1 (en) * | 2011-12-15 | 2013-06-20 | Gilead Sciences, Inc. | Amino quinoline derivatives inhibitors of hcv |
| US20140128431A1 (en) | 2012-04-03 | 2014-05-08 | Hoffmann-Laroche Inc. | Pharmaceutical composition with improved bioavailability, safety and tolerability |
| SG11201502369XA (en) | 2012-10-16 | 2015-05-28 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ror-gamma-t |
| WO2014062655A1 (en) | 2012-10-16 | 2014-04-24 | Janssen Pharmaceutica Nv | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt |
| ES2628365T3 (es) | 2012-10-16 | 2017-08-02 | Janssen Pharmaceutica N.V. | Moduladores de quinolinilo unidos a fenilo de ROR-GAMA-T |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| KR20160068956A (ko) | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | RORyT의 퀴놀리닐 조절제 |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| KR20160070133A (ko) | 2013-10-15 | 2016-06-17 | 얀센 파마슈티카 엔.브이. | RORyt의 알킬 결합 퀴놀리닐 조절제 |
| SG11201607973XA (en) * | 2014-03-24 | 2016-11-29 | Guangdong Zhongsheng Pharmaceutical Co Ltd | Quinoline derivatives as smo inhibitors |
| CN108137514A (zh) * | 2015-07-30 | 2018-06-08 | 百时美施贵宝公司 | 芳基取代的二环杂芳基化合物 |
| US11613543B2 (en) | 2018-03-26 | 2023-03-28 | Novartis Ag | Substituted pyrrolo[2,3-d]pyrimidines as Bruton's Tyrosine Kinase inhibitors |
| MX2021009764A (es) | 2019-02-15 | 2021-09-08 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona sustituidos y usos de los mismos. |
| EP4031243A1 (en) * | 2019-09-16 | 2022-07-27 | Novartis AG | Glue degraders and methods of use thereof |
| WO2021198981A1 (en) | 2020-04-01 | 2021-10-07 | Janssen Biopharma, Inc. | Antiviral compounds and uses thereof |
| CN111777549A (zh) * | 2020-07-07 | 2020-10-16 | 中瀚(齐河县)生物医药科技有限公司 | 一种2-甲氧基-3-溴-5-氟吡啶的合成工艺 |
| JP2023549738A (ja) * | 2020-10-30 | 2023-11-29 | １シーバイオ， インコーポレイテッド | エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼ－１（ｅｎｐｐ１）阻害物質及びそれらの使用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB558009A (en) * | 1942-05-08 | 1943-12-15 | Harold Coates | Quinoline derivatives |
| RU2029472C1 (ru) * | 1989-09-26 | 1995-02-27 | Сумитомо Кемикал Компани Лимитед | Производные урацила, промежуточные соединения, гербицидная композиция и способ борьбы с сорняками |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| EP1292310A1 (en) * | 2000-05-10 | 2003-03-19 | SmithKline Beecham Corporation | Novel anti-infectives |
| WO2009032123A2 (en) | 2007-08-29 | 2009-03-12 | Schering Corporation | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| MX2010002318A (es) | 2007-08-29 | 2010-03-22 | Schering Corp | Derivados azaindol 2,3-sustituidos para tratar infecciones virales. |
| TW200924751A (en) | 2007-08-29 | 2009-06-16 | Schering Corp | 2,3-substituted indole derivatives and methods of use thereof |
| ES2453591T3 (es) | 2007-09-17 | 2014-04-08 | Abbvie Bahamas Ltd. | Derivado de uracilo o timina para el tratamiento de la hepatitis C |
| HRP20110809T1 (hr) | 2007-09-17 | 2011-12-31 | Abbott Laboratories | Protuupalni pirimidini i njihove uporabe |
| EP2548873A1 (en) | 2007-09-17 | 2013-01-23 | Abbott Laboratories | N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors |
| US8765757B2 (en) | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| CA2705587A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| CN105924386A (zh) | 2009-03-25 | 2016-09-07 | Abbvie 公司 | 抗病毒化合物和其用途 |
| WO2010111437A1 (en) | 2009-03-25 | 2010-09-30 | Abbott Laboratories | Antiviral compounds and uses thereof |
-
2010
- 2010-06-07 AR ARP100101992A patent/AR077004A1/es unknown
- 2010-06-07 TW TW099118427A patent/TWI428332B/zh not_active IP Right Cessation
- 2010-06-08 ES ES10720797.9T patent/ES2525254T3/es active Active
- 2010-06-08 EP EP10720797.9A patent/EP2440528B1/en active Active
- 2010-06-08 BR BRPI1010852A patent/BRPI1010852A2/pt not_active IP Right Cessation
- 2010-06-08 SG SG2011091212A patent/SG176762A1/en unknown
- 2010-06-08 CN CN201080025186.6A patent/CN102803216B/zh not_active Expired - Fee Related
- 2010-06-08 KR KR1020127000604A patent/KR101431343B1/ko not_active Expired - Fee Related
- 2010-06-08 JP JP2012514440A patent/JP5612678B2/ja not_active Expired - Fee Related
- 2010-06-08 RU RU2011153788/04A patent/RU2540332C2/ru not_active IP Right Cessation
- 2010-06-08 MY MYPI2011005928A patent/MY157435A/en unknown
- 2010-06-08 MA MA34447A patent/MA33360B1/fr unknown
- 2010-06-08 PE PE2011002042A patent/PE20120937A1/es active IP Right Grant
- 2010-06-08 AU AU2010257592A patent/AU2010257592B2/en not_active Ceased
- 2010-06-08 WO PCT/EP2010/057958 patent/WO2010142656A1/en not_active Ceased
- 2010-06-08 NZ NZ596646A patent/NZ596646A/en not_active IP Right Cessation
- 2010-06-08 MX MX2011013209A patent/MX2011013209A/es active IP Right Grant
- 2010-06-08 PE PE2015001204A patent/PE20151092A1/es not_active Application Discontinuation
- 2010-06-08 CA CA2764141A patent/CA2764141C/en not_active Expired - Fee Related
- 2010-06-09 US US12/797,308 patent/US8026253B2/en not_active Expired - Fee Related
-
2011
- 2011-08-18 US US13/212,742 patent/US8487103B2/en not_active Expired - Fee Related
- 2011-11-16 CR CR20110605A patent/CR20110605A/es unknown
- 2011-11-17 IL IL216412A patent/IL216412A/en not_active IP Right Cessation
- 2011-11-24 CO CO11161639A patent/CO6400218A2/es active IP Right Grant
- 2011-12-05 ZA ZA2011/08921A patent/ZA201108921B/en unknown
- 2011-12-09 EC EC2011011513A patent/ECSP11011513A/es unknown
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