PE20151894A1 - Composiciones y metodos de variantes de inhibidor tisular de la metaloproteinasa tipo tres (timp 3) - Google Patents
Composiciones y metodos de variantes de inhibidor tisular de la metaloproteinasa tipo tres (timp 3)Info
- Publication number
- PE20151894A1 PE20151894A1 PE2015002011A PE2015002011A PE20151894A1 PE 20151894 A1 PE20151894 A1 PE 20151894A1 PE 2015002011 A PE2015002011 A PE 2015002011A PE 2015002011 A PE2015002011 A PE 2015002011A PE 20151894 A1 PE20151894 A1 PE 20151894A1
- Authority
- PE
- Peru
- Prior art keywords
- timp
- methods
- metaloproteinase
- compositions
- type
- Prior art date
Links
- 102000005406 Tissue Inhibitor of Metalloproteinase-3 Human genes 0.000 title abstract 2
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- General Chemical & Material Sciences (AREA)
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- Biomedical Technology (AREA)
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- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
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Abstract
Se describen muteinas TIMP-3, variantes y derivados, los acidos nucleicos que las codifican, y los metodos de fabricacion y uso de ellos
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782613P | 2013-03-14 | 2013-03-14 | |
| US201361798160P | 2013-03-15 | 2013-03-15 | |
| US201361802988P | 2013-03-18 | 2013-03-18 | |
| US201461940673P | 2014-02-17 | 2014-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20151894A1 true PE20151894A1 (es) | 2016-01-08 |
Family
ID=50473803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002011A PE20151894A1 (es) | 2013-03-14 | 2014-03-13 | Composiciones y metodos de variantes de inhibidor tisular de la metaloproteinasa tipo tres (timp 3) |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10189890B2 (es) |
| EP (1) | EP2970407B1 (es) |
| JP (6) | JP2016513666A (es) |
| KR (1) | KR102258564B1 (es) |
| CN (2) | CN105531285B (es) |
| AP (1) | AP2015008729A0 (es) |
| AU (5) | AU2014236683B2 (es) |
| BR (1) | BR112015022491A2 (es) |
| CA (1) | CA2906053C (es) |
| CL (1) | CL2015002663A1 (es) |
| EA (1) | EA034200B1 (es) |
| IL (1) | IL241246B (es) |
| MX (1) | MX380644B (es) |
| PE (1) | PE20151894A1 (es) |
| PH (1) | PH12015502059A1 (es) |
| SG (2) | SG11201507524TA (es) |
| TN (1) | TN2015000423A1 (es) |
| TW (3) | TWI685501B (es) |
| WO (1) | WO2014152012A2 (es) |
| ZA (2) | ZA201506746B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105764523A (zh) * | 2013-09-18 | 2016-07-13 | 詹姆斯库克大学 | 抗炎蛋白及使用方法 |
| CA3193070A1 (en) | 2014-05-07 | 2015-11-12 | Amgen Inc. | Autoinjector with shock reducing elements |
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| CA2956726C (en) * | 2014-08-27 | 2023-06-06 | Amgen Inc. | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
| JP6766040B2 (ja) | 2014-10-14 | 2020-10-07 | アムジエン・インコーポレーテツド | 視覚および可聴インジケータを備える薬剤注射装置 |
| US11357916B2 (en) | 2014-12-19 | 2022-06-14 | Amgen Inc. | Drug delivery device with live button or user interface field |
| WO2016133947A1 (en) | 2015-02-17 | 2016-08-25 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
| EP3261690B1 (en) | 2015-02-27 | 2021-12-15 | Amgen Inc. | Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement |
| WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
| EP3386573B1 (en) | 2015-12-09 | 2019-10-02 | Amgen Inc. | Auto-injector with signaling cap |
| US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
| ES2814287T3 (es) | 2016-03-15 | 2021-03-26 | Amgen Inc | Reducir la probabilidad de rotura de cristal en dispositivos de administración de fármaco |
| WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
| US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
| US10988284B2 (en) | 2016-05-13 | 2021-04-27 | Amgen Inc. | Vial sleeve assembly |
| WO2017200989A1 (en) | 2016-05-16 | 2017-11-23 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
| WO2017209899A1 (en) | 2016-06-03 | 2017-12-07 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
| US11285266B2 (en) | 2016-07-01 | 2022-03-29 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
| US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
| WO2018081234A1 (en) | 2016-10-25 | 2018-05-03 | Amgen Inc. | On-body injector |
| CA3049780A1 (en) | 2017-01-17 | 2018-07-26 | Amgen Inc. | Injection devices and related methods of use and assembly |
| CA3052204A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Insertion mechanism for drug delivery device |
| US11752258B2 (en) | 2017-02-17 | 2023-09-12 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
| AU2018231107B2 (en) | 2017-03-06 | 2023-04-20 | Amgen Inc. | Drug delivery device with activation prevention feature |
| WO2018164829A1 (en) | 2017-03-07 | 2018-09-13 | Amgen Inc. | Needle insertion by overpressure |
| IL303449B2 (en) | 2017-03-09 | 2024-08-01 | Amgen Inc | Insertion mechanism for a drug delivery device |
| LT3600491T (lt) | 2017-03-28 | 2023-10-10 | Amgen Inc. | Stūmoklio koto ir švirkšto konstrukcinė sistema ir būdas |
| AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
| US11904143B2 (en) | 2017-06-08 | 2024-02-20 | Amgen Inc. | Torque driven drug delivery device |
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| US11395880B2 (en) | 2017-06-23 | 2022-07-26 | Amgen Inc. | Electronic drug delivery device |
| EP3651832B1 (en) | 2017-07-14 | 2023-12-13 | Amgen Inc. | Needle insertion-retraction system having dual torsion spring system |
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| WO2019022950A1 (en) | 2017-07-25 | 2019-01-31 | Amgen Inc. | DRUG DELIVERY DEVICE WITH CONTAINER ACCESS SYSTEM AND ASSEMBLY METHOD THEREOF |
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| EP3668567A1 (en) | 2017-08-18 | 2020-06-24 | Amgen Inc. | Wearable injector with sterile adhesive patch |
| US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
| EP3691717B1 (en) | 2017-10-04 | 2023-02-08 | Amgen Inc. | Flow adapter for drug delivery device |
| WO2019070552A1 (en) | 2017-10-06 | 2019-04-11 | Amgen Inc. | DRUG DELIVERY DEVICE COMPRISING A LOCKOUT ASSEMBLY AND ASSOCIATED ASSEMBLY METHOD |
| MA50348A (fr) | 2017-10-09 | 2020-08-19 | Amgen Inc | Dispositif d'administration de médicament comprenant un ensemble d'entraînement et procédé d'assemblage associé |
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| MA50569A (fr) | 2017-11-06 | 2020-09-16 | Amgen Inc | Ensembles de remplissage-finition et procédés associés |
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| US6562596B1 (en) | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
| JPH09235300A (ja) * | 1996-02-29 | 1997-09-09 | Fuji Yakuhin Kogyo Kk | ヒトｔｉｍｐ−３及び抗ヒトｔｉｍｐ−３モノクローナル抗体並びにその用途 |
| JP5025045B2 (ja) * | 2001-02-02 | 2012-09-12 | マルホ株式会社 | 多硫酸化多糖類によるｔｉｍｐ産生の亢進 |
| US7183256B2 (en) | 2003-03-21 | 2007-02-27 | Cleveland Clinic Foundation | TIMP3 as VEGF inhibitor |
| US7641643B2 (en) | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| KR101451620B1 (ko) * | 2005-05-12 | 2014-10-21 | 글락소 그룹 리미티드 | 백신 조성물 |
| AU2006275554A1 (en) | 2005-07-29 | 2007-02-08 | Imperial Innovations Limited | Mutant timp-3 |
| EP2136831B1 (en) * | 2007-03-02 | 2012-09-12 | The Cleveland Clinic Foundation | Anti-angiogenic peptides |
| EP2811017A2 (en) * | 2008-04-21 | 2014-12-10 | Novo Nordisk Health Care AG | Hyperglycosylated human coagulation factor IX |
| EP2370581B1 (en) * | 2008-12-04 | 2016-08-03 | CuRNA, Inc. | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
| AU2010278959A1 (en) * | 2009-07-31 | 2012-02-02 | Amgen Inc. | Polypeptides that bind tissue inhibitor of metalloproteinase type three (TIMP-3), compositions and methods |
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