PE20151718A1 - Compuestos piridinilpirazoloquinolina - Google Patents
Compuestos piridinilpirazoloquinolinaInfo
- Publication number
- PE20151718A1 PE20151718A1 PE2015001977A PE2015001977A PE20151718A1 PE 20151718 A1 PE20151718 A1 PE 20151718A1 PE 2015001977 A PE2015001977 A PE 2015001977A PE 2015001977 A PE2015001977 A PE 2015001977A PE 20151718 A1 PE20151718 A1 PE 20151718A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- group
- pyridinylpirazoloquinoline
- pyridinylpyrazoloquinoline
- methyltetrahydro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- -1 4-methoxycyclohexyl group Chemical group 0.000 abstract 1
- 101001117256 Drosophila melanogaster High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Proteins 0.000 abstract 1
- FAVYXMCEBCIYKB-UHFFFAOYSA-N N1=C(C=CC=C1)C=1NC2=C3C(C=CC2=CC1)=NN=C3 Chemical compound N1=C(C=CC=C1)C=1NC2=C3C(C=CC2=CC1)=NN=C3 FAVYXMCEBCIYKB-UHFFFAOYSA-N 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Referida a un compuesto derivado de piridinilpirazoloquinolina representado por la formula (I), o una sal farmaceuticamente aceptable del mismo, donde R1 es un grupo a), b) o c), y R2 es un grupo 3-metiltetrahidro-2H-piran-4-ilo o un grupo 4-metoxiciclohexilo. Dichos compuestos tienen actividad inhibidora contra la fosfodiesterasa 9 (PDE 9), y son utiles en el tratamiento de deficiencias cognitivas como el Alzheimer
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809118P | 2013-04-05 | 2013-04-05 | |
| US201361809095P | 2013-04-05 | 2013-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20151718A1 true PE20151718A1 (es) | 2015-11-22 |
Family
ID=51658437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015001977A PE20151718A1 (es) | 2013-04-05 | 2014-04-03 | Compuestos piridinilpirazoloquinolina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9550776B2 (es) |
| EP (1) | EP2982674B1 (es) |
| JP (1) | JP6244353B2 (es) |
| KR (1) | KR102234131B1 (es) |
| CN (1) | CN105189496B (es) |
| AU (1) | AU2014250391B2 (es) |
| BR (1) | BR112015024075B1 (es) |
| CA (1) | CA2904820C (es) |
| CL (1) | CL2015002837A1 (es) |
| ES (1) | ES2654094T3 (es) |
| HK (1) | HK1219100A1 (es) |
| IL (1) | IL241695B (es) |
| MX (1) | MX363258B (es) |
| PE (1) | PE20151718A1 (es) |
| PH (1) | PH12015502178A1 (es) |
| RU (1) | RU2655172C2 (es) |
| SG (1) | SG11201507733YA (es) |
| TW (1) | TW201439091A (es) |
| WO (1) | WO2014163146A1 (es) |
| ZA (1) | ZA201507044B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201406486D0 (en) | 2014-04-10 | 2014-05-28 | Redx Pharma Ltd | Antibacterial compounds |
| WO2017046606A1 (en) * | 2015-09-18 | 2017-03-23 | Redx Pharma Plc | Antibacterial compounds |
| US11311530B2 (en) | 2017-06-01 | 2022-04-26 | Eisai R&D Management Co., Ltd. | Lewy body disease therapeutic agent containing pyrazoloquinoline derivative |
| US11512067B2 (en) | 2017-09-14 | 2022-11-29 | Daiichi Sankyo Company, Limited | Compound having cyclic structure |
| US11530218B2 (en) | 2020-01-20 | 2022-12-20 | Incyte Corporation | Spiro compounds as inhibitors of KRAS |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| CR20240059A (es) | 2021-07-07 | 2024-03-21 | Incyte Corp | Compuestos tricíclicos como inhibidores de kras. |
| CA3229855A1 (en) | 2021-08-31 | 2023-03-09 | Incyte Corporation | Naphthyridine compounds as inhibitors of kras |
| WO2023049697A1 (en) | 2021-09-21 | 2023-03-30 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of kras |
| JP2024537824A (ja) | 2021-10-01 | 2024-10-16 | インサイト・コーポレイション | ピラゾロキノリンｋｒａｓ阻害剤 |
| WO2023064857A1 (en) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05132484A (ja) | 1991-04-26 | 1993-05-28 | Otsuka Pharmaceut Factory Inc | ピラゾロキノリン及びピラゾロナフチリジン誘導体 |
| RU2145606C1 (ru) | 1994-05-24 | 2000-02-20 | Ф.Хоффманн-Ля Рош Аг | Трициклические дикарбонильные производные и лекарственный препарат на их основе |
| DE102004004142A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
| WO2005118583A1 (en) | 2004-05-28 | 2005-12-15 | Millennium Pharmaceuticals, Inc. | 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors |
| JP2006045118A (ja) | 2004-08-04 | 2006-02-16 | Mochida Pharmaceut Co Ltd | 新規ピラゾロキノロン誘導体 |
| CN101268073B (zh) | 2005-09-15 | 2011-10-19 | Aska制药株式会社 | 杂环化合物、制备方法及其用途 |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| JP5578786B2 (ja) | 2006-12-13 | 2014-08-27 | あすか製薬株式会社 | キノキサリン誘導体 |
| SI2152712T1 (sl) | 2007-05-11 | 2012-03-30 | Pfizer | Amino heterociklične spojine |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| KR20110132559A (ko) | 2009-03-05 | 2011-12-08 | 아스텔라스세이야쿠 가부시키가이샤 | 퀴녹살린 화합물 |
| BRPI1011533A2 (pt) | 2009-03-31 | 2016-03-29 | Boehringer Ingelheim Int | derivados de 1-heterocicil-1 5- diidro-pirazolo [3,4--d] pirimidin-4-ona e seu uso como moduladores de pde9a. |
| SI2615089T1 (sl) | 2010-09-07 | 2016-08-31 | Astellas Pharma Inc. | Spojine pirazolokinolina |
| JP6042060B2 (ja) | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| EP2573073B1 (en) * | 2011-09-26 | 2014-10-22 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
| CN103930423B (zh) * | 2011-10-07 | 2015-09-16 | 卫材Rd管理有限公司 | 吡唑并喹啉衍生物 |
-
2014
- 2014-04-03 RU RU2015140669A patent/RU2655172C2/ru active
- 2014-04-03 SG SG11201507733YA patent/SG11201507733YA/en unknown
- 2014-04-03 TW TW103112618A patent/TW201439091A/zh unknown
- 2014-04-03 HK HK16107121.9A patent/HK1219100A1/en unknown
- 2014-04-03 US US14/778,202 patent/US9550776B2/en active Active
- 2014-04-03 CA CA2904820A patent/CA2904820C/en active Active
- 2014-04-03 MX MX2015013446A patent/MX363258B/es unknown
- 2014-04-03 WO PCT/JP2014/059852 patent/WO2014163146A1/ja not_active Ceased
- 2014-04-03 EP EP14780073.4A patent/EP2982674B1/en active Active
- 2014-04-03 PE PE2015001977A patent/PE20151718A1/es not_active Application Discontinuation
- 2014-04-03 CN CN201480016592.4A patent/CN105189496B/zh active Active
- 2014-04-03 KR KR1020157026010A patent/KR102234131B1/ko active Active
- 2014-04-03 BR BR112015024075-5A patent/BR112015024075B1/pt active IP Right Grant
- 2014-04-03 AU AU2014250391A patent/AU2014250391B2/en active Active
- 2014-04-03 ES ES14780073.4T patent/ES2654094T3/es active Active
- 2014-04-03 JP JP2015510131A patent/JP6244353B2/ja active Active
-
2015
- 2015-09-17 PH PH12015502178A patent/PH12015502178A1/en unknown
- 2015-09-17 IL IL241695A patent/IL241695B/en active IP Right Grant
- 2015-09-22 ZA ZA2015/07044A patent/ZA201507044B/en unknown
- 2015-09-23 CL CL2015002837A patent/CL2015002837A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6244353B2 (ja) | 2017-12-06 |
| BR112015024075A2 (pt) | 2017-10-24 |
| CN105189496B (zh) | 2017-03-29 |
| RU2015140669A3 (es) | 2018-03-21 |
| AU2014250391B2 (en) | 2017-11-02 |
| US9550776B2 (en) | 2017-01-24 |
| RU2015140669A (ru) | 2017-05-11 |
| CA2904820A1 (en) | 2014-10-09 |
| TW201439091A (zh) | 2014-10-16 |
| CN105189496A (zh) | 2015-12-23 |
| SG11201507733YA (en) | 2015-10-29 |
| HK1219100A1 (en) | 2017-03-24 |
| IL241695B (en) | 2019-06-30 |
| ZA201507044B (en) | 2017-02-22 |
| US20160289225A1 (en) | 2016-10-06 |
| WO2014163146A1 (ja) | 2014-10-09 |
| KR20150138204A (ko) | 2015-12-09 |
| RU2655172C2 (ru) | 2018-05-24 |
| AU2014250391A1 (en) | 2015-10-15 |
| EP2982674A4 (en) | 2016-08-31 |
| MX2015013446A (es) | 2016-01-12 |
| JPWO2014163146A1 (ja) | 2017-02-16 |
| KR102234131B1 (ko) | 2021-04-01 |
| ES2654094T3 (es) | 2018-02-12 |
| CA2904820C (en) | 2021-05-18 |
| BR112015024075B1 (pt) | 2022-05-03 |
| EP2982674A1 (en) | 2016-02-10 |
| MX363258B (es) | 2019-03-19 |
| CL2015002837A1 (es) | 2016-04-22 |
| EP2982674B1 (en) | 2017-10-25 |
| PH12015502178A1 (en) | 2016-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |