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PE20150024A1 - Compuestos que inhiben la actividad de catecol o-metiltransferasa - Google Patents

Compuestos que inhiben la actividad de catecol o-metiltransferasa

Info

Publication number
PE20150024A1
PE20150024A1 PE2014002055A PE2014002055A PE20150024A1 PE 20150024 A1 PE20150024 A1 PE 20150024A1 PE 2014002055 A PE2014002055 A PE 2014002055A PE 2014002055 A PE2014002055 A PE 2014002055A PE 20150024 A1 PE20150024 A1 PE 20150024A1
Authority
PE
Peru
Prior art keywords
activity
compounds
catecol
methyltransferase
inhibit
Prior art date
Application number
PE2014002055A
Other languages
English (en)
Inventor
Marko Ahlmark
Belle David Din
Mika Kauppala
Anne Luiro
Taina Pajunen
Jarmo Pystynen
Eija Tiainen
Matti Vaismaa
Josef Messinger
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48669995&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20150024(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corp filed Critical Orion Corp
Publication of PE20150024A1 publication Critical patent/PE20150024A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDER1 ES ALQUILO (C1-C6), ALQUENILO (C2-C6), ALQUINILO (C2-C6). SON COMPUESTOS PREFERIDOS 2-BROMO-4,5-DIHIDROXIISOFTALONITRILO; 4,5-DIHIDROXI-2-(FENILETINIL)ISOFTALONITRILO, ENTRE OTROS. DICHO COMPUESTO EXHIBE ACTIVIDAD QUE INHIBE LA ENZIMA COMT Y DE ESTA MANERA SON UTILES COMO INHIBIDORES COMT
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