PE20142331A1 - METHOD OF PREPARING A COMPOUND BY THE ADDITION REACTION OF MICHAEL NOVEDOSA USING WATER OR VARIOUS ACIDS AS ADDITIVE - Google Patents
METHOD OF PREPARING A COMPOUND BY THE ADDITION REACTION OF MICHAEL NOVEDOSA USING WATER OR VARIOUS ACIDS AS ADDITIVEInfo
- Publication number
- PE20142331A1 PE20142331A1 PE2014001218A PE2014001218A PE20142331A1 PE 20142331 A1 PE20142331 A1 PE 20142331A1 PE 2014001218 A PE2014001218 A PE 2014001218A PE 2014001218 A PE2014001218 A PE 2014001218A PE 20142331 A1 PE20142331 A1 PE 20142331A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- michael
- preparing
- formula
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000007259 addition reaction Methods 0.000 title 1
- 239000000654 additive Substances 0.000 title 1
- 230000000996 additive effect Effects 0.000 title 1
- -1 t-BUTYL Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 229940125782 compound 2 Drugs 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
- C07B37/02—Addition
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/64—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/62—Use of additives, e.g. for stabilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA A UN METODO PARA PREPARAR UN COMPUESTO DE FORMULA 1 QUE COMPRENDE ADICIONAR AGUA O ACIDO O UNA MEZCLA DE LOS MISMOS A UNA MEZCLA DE REACCION PARA PREPARAR EL COMPUESTO 1 A TRAVES DE LA REACCION DE ADICION DE MICHAEL ENTRE EL COMPUESTO DE FORMULA 2 Y EL COMPUESTO DE FORMULA 3 EN PRESENCIA DE COBRE, DONDE A ES R1-C(=O), NITRILO, ALQUILSULFONILO C1-C10, ENTRE OTROS; R1 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C10, ENTRE OTROS; R2, R3 Y R4 SON H, ALQUILO C1-C10, CICLOALQUILO C3-C10, ARILO C6-C10, ENTRE OTROS; R5 Y R6 SON H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; P1 ES BENCILO, METILO, ETILO, i-PROPILO O t-BUTILO; X ES UN HALOGENO. eL ACIDO ES UN ACIDO INORGANICO TAL COMO ACIDO CLORHIDRICO, SULFURICO, NITRICO, ENTRE OTROS O UN ACIDO ORGANICO TAL COMO ACIDO FORMICO, ACETICO Y TARTARICOREFERRING TO A METHOD FOR PREPARING A COMPOUND OF FORMULA 1 WHICH INCLUDES ADDING WATER OR ACID OR A MIX OF THE SAME TO A REACTION MIXTURE TO PREPARE COMPOUND 1 THROUGH THE REACTION OF ADDITION OF MICHAEL AND FORMULA 2 BETWEEN THE COMPOUND 2 OF FORMULA 2 COMPOUND OF FORMULA 3 IN THE PRESENCE OF COPPER, WHERE A IS R1-C (= O), NITRILE, C1-C10 ALKYLSULFONYL, AMONG OTHERS; R1 IS H, C1-C10 ALKYL, C3-C10 CYCLOALKYL, AMONG OTHERS; R2, R3 AND R4 ARE H, C1-C10 ALKYL, C3-C10 CYCLOALKYL, C6-C10 ARYL, AMONG OTHERS; R5 AND R6 ARE H, HALOGEN, C1-C4 ALKYL, AMONG OTHERS; P1 IS BENZYL, METHYL, ETHYL, i-PROPYL OR t-BUTYL; X IS A HALOGEN. THE ACID IS AN INORGANIC ACID SUCH AS HYDROCHLORIC, SULFURIC, NITRIC ACID, AMONG OTHERS OR AN ORGANIC ACID SUCH AS FORMIC, ACETIC AND TARTARIC ACIDS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20120011317 | 2012-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20142331A1 true PE20142331A1 (en) | 2015-01-17 |
Family
ID=48905559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014001218A PE20142331A1 (en) | 2012-02-03 | 2013-02-01 | METHOD OF PREPARING A COMPOUND BY THE ADDITION REACTION OF MICHAEL NOVEDOSA USING WATER OR VARIOUS ACIDS AS ADDITIVE |
Country Status (16)
| Country | Link |
|---|---|
| KR (1) | KR101539761B1 (en) |
| CN (1) | CN104159884B (en) |
| AU (1) | AU2013215796B2 (en) |
| BR (1) | BR112014018985B1 (en) |
| CL (1) | CL2014002029A1 (en) |
| CO (1) | CO7030967A2 (en) |
| EA (1) | EA026411B1 (en) |
| MA (1) | MA35906B1 (en) |
| MX (1) | MX355336B (en) |
| MY (1) | MY168411A (en) |
| PE (1) | PE20142331A1 (en) |
| PH (1) | PH12014501704B1 (en) |
| SG (1) | SG11201404396TA (en) |
| TN (1) | TN2014000329A1 (en) |
| WO (1) | WO2013115595A1 (en) |
| ZA (1) | ZA201405598B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9774740B2 (en) | 2008-01-28 | 2017-09-26 | Afiniti Europe Technologies Limited | Techniques for benchmarking pairing strategies in a contact center system |
| CN108191647B (en) * | 2018-02-22 | 2020-09-29 | 江苏尚莱特医药化工材料有限公司 | Synthesis method of 2, 2-difluoro dicarboxylic acid dialkyl ester |
| CN113149823B (en) * | 2021-03-29 | 2023-12-08 | 上海青平药业有限公司 | 2-R 1 Process for preparing valeric acid |
| CN113354495A (en) * | 2021-05-20 | 2021-09-07 | 上海应用技术大学 | Difluorone carbonyl substituted asymmetric nitrile compound and preparation and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS573159B2 (en) * | 1973-12-05 | 1982-01-20 | ||
| EP0188256B1 (en) * | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
| DE60225199T2 (en) * | 2001-03-07 | 2009-03-05 | Firmenich S.A. | Process for the preparation of Michael adducts |
| AU2008341352B2 (en) * | 2007-12-21 | 2013-08-01 | Lg Chem, Ltd. | Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent |
-
2013
- 2013-02-01 AU AU2013215796A patent/AU2013215796B2/en active Active
- 2013-02-01 MY MYPI2014702072A patent/MY168411A/en unknown
- 2013-02-01 KR KR1020130011722A patent/KR101539761B1/en active Active
- 2013-02-01 SG SG11201404396TA patent/SG11201404396TA/en unknown
- 2013-02-01 WO PCT/KR2013/000829 patent/WO2013115595A1/en not_active Ceased
- 2013-02-01 BR BR112014018985-4A patent/BR112014018985B1/en active IP Right Grant
- 2013-02-01 PE PE2014001218A patent/PE20142331A1/en active IP Right Grant
- 2013-02-01 MX MX2014009309A patent/MX355336B/en active IP Right Grant
- 2013-02-01 EA EA201491463A patent/EA026411B1/en active IP Right Grant
- 2013-02-01 CN CN201380007885.1A patent/CN104159884B/en active Active
-
2014
- 2014-07-28 PH PH12014501704A patent/PH12014501704B1/en unknown
- 2014-07-29 ZA ZA2014/05598A patent/ZA201405598B/en unknown
- 2014-07-30 CL CL2014002029A patent/CL2014002029A1/en unknown
- 2014-07-31 TN TNP2014000329A patent/TN2014000329A1/en unknown
- 2014-08-12 MA MA37281A patent/MA35906B1/en unknown
- 2014-08-12 CO CO14176211A patent/CO7030967A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201405598B (en) | 2015-09-30 |
| MY168411A (en) | 2018-11-09 |
| PH12014501704A1 (en) | 2014-10-13 |
| AU2013215796B2 (en) | 2016-09-15 |
| BR112014018985A2 (en) | 2017-06-20 |
| EA026411B1 (en) | 2017-04-28 |
| MX2014009309A (en) | 2014-11-10 |
| TN2014000329A1 (en) | 2015-12-21 |
| MA35906B1 (en) | 2014-12-01 |
| BR112014018985B1 (en) | 2021-01-19 |
| WO2013115595A1 (en) | 2013-08-08 |
| PH12014501704B1 (en) | 2014-10-13 |
| KR101539761B1 (en) | 2015-07-28 |
| CL2014002029A1 (en) | 2014-12-26 |
| CN104159884B (en) | 2016-01-13 |
| SG11201404396TA (en) | 2015-06-29 |
| AU2013215796A1 (en) | 2014-08-21 |
| MX355336B (en) | 2018-04-16 |
| CN104159884A (en) | 2014-11-19 |
| CO7030967A2 (en) | 2014-08-21 |
| EA201491463A1 (en) | 2014-11-28 |
| KR20130090360A (en) | 2013-08-13 |
| BR112014018985A8 (en) | 2017-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |