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PE20131219A1 - Metodo para la preparacion de acido montelukast en un medio liquido ionico - Google Patents

Metodo para la preparacion de acido montelukast en un medio liquido ionico

Info

Publication number
PE20131219A1
PE20131219A1 PE2013000260A PE2013000260A PE20131219A1 PE 20131219 A1 PE20131219 A1 PE 20131219A1 PE 2013000260 A PE2013000260 A PE 2013000260A PE 2013000260 A PE2013000260 A PE 2013000260A PE 20131219 A1 PE20131219 A1 PE 20131219A1
Authority
PE
Peru
Prior art keywords
ethyl
formula
preparation
liquid medium
ionic liquid
Prior art date
Application number
PE2013000260A
Other languages
English (en)
Inventor
Chul-Hyun Park
Eun-Ju Park
Choong-Hahn Kim
Suk Man Jang
Eun Jung Lim
Young Kil Chang
Gwan Sun Lee
Jaeheon Lee
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40549354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131219(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of PE20131219A1 publication Critical patent/PE20131219A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN METODO PARA PREPARAR ACIDO MONTELUKAST DE LA FORMULA (1), QUE COMPRENDE: ACOPLAR UN COMPUESTO DE TIOL DE FORMULA (2) CON UN MONTELUKAST INTERMEDIO DE FORMULA (3) EN PRESENCIA DE UNA BASE TAL COMO T-BUTILATO DE POTASIO, T-BUTILATO DE SODIO, NaH, NaOH Y KOH, EN UN MEDIO QUE CONTENGA UN COMPUESTO LIQUIDO IONICO SELECCIONADO DE 1-ETIL-3-METILIMIDAZOLIUM BROMURO, 1-ETIL-3-METILIMIDAZOLIUM HEXAFLUOROFOSFATO, N-BUTIL-N-METILPIRROLIDIUM, ENTRE OTROS; DONDE R1 ES H, METILO O ETILO. DICHO COMPUESTO BLOQUEA O INHIBE LA SINTESIS DE LEUCOTRIENOS Y ES DE UTILIDAD PARA TRASTORNOS INFLAMATORIOS
PE2013000260A 2007-10-09 2008-10-09 Metodo para la preparacion de acido montelukast en un medio liquido ionico PE20131219A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020070101486A KR101072896B1 (ko) 2007-10-09 2007-10-09 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법

Publications (1)

Publication Number Publication Date
PE20131219A1 true PE20131219A1 (es) 2013-11-16

Family

ID=40549354

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013000260A PE20131219A1 (es) 2007-10-09 2008-10-09 Metodo para la preparacion de acido montelukast en un medio liquido ionico
PE2008001742A PE20091369A1 (es) 2007-10-09 2008-10-09 Metodo para la preparacion de acido montelukast en un medio liquido ionico

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2008001742A PE20091369A1 (es) 2007-10-09 2008-10-09 Metodo para la preparacion de acido montelukast en un medio liquido ionico

Country Status (18)

Country Link
US (1) US8426599B2 (es)
EP (1) EP2195295B1 (es)
JP (1) JP5210389B2 (es)
KR (1) KR101072896B1 (es)
CN (1) CN101808998B (es)
AR (1) AR068755A1 (es)
CA (1) CA2701912C (es)
CL (1) CL2008002996A1 (es)
DK (1) DK2195295T3 (es)
ES (1) ES2398732T3 (es)
HR (1) HRP20130103T1 (es)
MX (1) MX2010001864A (es)
PE (2) PE20131219A1 (es)
PL (1) PL2195295T3 (es)
PT (1) PT2195295E (es)
RU (1) RU2436774C1 (es)
TW (1) TWI350284B (es)
WO (1) WO2009048236A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP1000425A2 (en) 2010-08-11 2012-03-28 Richter Gedeon Nyrt Process for the production of montelukast sodium
CN103570618A (zh) * 2013-09-30 2014-02-12 浙江车头制药股份有限公司 一种孟鲁司特钠盐的制备方法
CN105294556A (zh) * 2014-06-06 2016-02-03 上海迪赛诺化学制药有限公司 一种制备孟鲁司特酸的方法
WO2020049505A1 (en) 2018-09-06 2020-03-12 Innopharmascreen Inc. Methods and compositions for treatment of asthma or parkinson's disease
KR102181155B1 (ko) * 2019-09-26 2020-11-20 대봉엘에스 주식회사 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법
CN111961083B (zh) * 2020-08-27 2022-11-25 鲁南制药集团股份有限公司 一种孟鲁司特钠中间体化合物
CN111892535B (zh) * 2020-08-27 2023-04-11 鲁南制药集团股份有限公司 一种孟鲁司特钠的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053209C (en) 1990-10-12 1998-12-08 Michel L. Belley Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
MY107767A (en) * 1992-04-10 1996-06-15 Merck Frosst Canada Inc Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
TW416948B (en) 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
US5523477A (en) 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
JP2007518826A (ja) * 2004-01-30 2007-07-12 テバ ファーマシューティカル インダストリーズ リミティド モンテルカスト遊離酸多形体
DE602005015174D1 (de) 2004-04-21 2009-08-13 Teva Pharma Verfahren zur herstellung von montelukast-natrium
JP2006089463A (ja) * 2004-08-24 2006-04-06 Sumitomo Chemical Co Ltd アリールエーテル類の製造方法
WO2006064269A2 (en) * 2004-12-17 2006-06-22 Cipla Limited Salts of leukotriene antagonist montelukast
GB0500029D0 (en) * 2005-01-04 2005-02-09 Univ Belfast Basic ionic liquids
CN101326275B (zh) 2005-10-07 2013-06-05 阿拉巴马大学 多功能离子液体组合物
EP1783117A1 (en) 2005-11-04 2007-05-09 Esteve Quimica, S.A. Process for the preparation of a leukotriene antagonist and intermediates thereof
WO2007069261A1 (en) * 2005-12-13 2007-06-21 Msn Laboratories Limited An improved process for the preparation of montelukast and its pharmaceutically acceptable salts
CA2632954A1 (en) * 2005-12-23 2007-06-28 Glade Organics Private Limited An improved process for the manufacture of montelukast sodium
IL181607A0 (en) * 2006-02-27 2007-07-04 Chemagis Ltd Novel process for preparing montelukast and salts thereof
KR100774088B1 (ko) 2006-12-14 2007-11-06 한미약품 주식회사 몬테루카스트의 제조방법 및 이에 사용되는 중간체

Also Published As

Publication number Publication date
KR20090036349A (ko) 2009-04-14
US8426599B2 (en) 2013-04-23
DK2195295T3 (da) 2013-05-06
PE20091369A1 (es) 2009-10-01
RU2436774C1 (ru) 2011-12-20
TW200920737A (en) 2009-05-16
US20110105757A1 (en) 2011-05-05
PT2195295E (pt) 2013-02-28
JP5210389B2 (ja) 2013-06-12
AR068755A1 (es) 2009-12-02
CA2701912C (en) 2013-04-02
CL2008002996A1 (es) 2009-04-13
ES2398732T3 (es) 2013-03-21
CA2701912A1 (en) 2009-04-16
CN101808998B (zh) 2012-10-24
TWI350284B (en) 2011-10-11
WO2009048236A1 (en) 2009-04-16
HRP20130103T1 (hr) 2013-02-28
JP2011500555A (ja) 2011-01-06
PL2195295T3 (pl) 2013-06-28
KR101072896B1 (ko) 2011-10-17
EP2195295A1 (en) 2010-06-16
MX2010001864A (es) 2010-03-15
EP2195295A4 (en) 2011-04-13
EP2195295B1 (en) 2013-01-23
CN101808998A (zh) 2010-08-18

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