PE20121183A1 - COMPOUND (R) -N- (6- (1H-IMIDAZOL-1-IL) PYRIMIDIN-4-IL) -4H-1´-AZASPIRO [OXAZOL-5,3´-BICICLO [2.2.2] OCTAN] -2 -AMINE AS LIGANDS OF ACETYLCHOLINE NICOTINE ALPHA-7 RECEPTOR - Google Patents
COMPOUND (R) -N- (6- (1H-IMIDAZOL-1-IL) PYRIMIDIN-4-IL) -4H-1´-AZASPIRO [OXAZOL-5,3´-BICICLO [2.2.2] OCTAN] -2 -AMINE AS LIGANDS OF ACETYLCHOLINE NICOTINE ALPHA-7 RECEPTORInfo
- Publication number
- PE20121183A1 PE20121183A1 PE2012000594A PE2012000594A PE20121183A1 PE 20121183 A1 PE20121183 A1 PE 20121183A1 PE 2012000594 A PE2012000594 A PE 2012000594A PE 2012000594 A PE2012000594 A PE 2012000594A PE 20121183 A1 PE20121183 A1 PE 20121183A1
- Authority
- PE
- Peru
- Prior art keywords
- octan
- azaspiro
- oxazol
- amine
- biciclo
- Prior art date
Links
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 2
- POPPVIRYGJQIOF-UHFFFAOYSA-N 2-acetyloxyethyl(trimethyl)azanium;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CC(=O)OCC[N+](C)(C)C.CN1CCCC1C1=CC=CN=C1 POPPVIRYGJQIOF-UHFFFAOYSA-N 0.000 title 1
- YBGBTGGBNZEUJS-UHFFFAOYSA-N 5-chloro-1,3-thiazole Chemical compound ClC1=CN=CS1 YBGBTGGBNZEUJS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE QUINUCLIDINA DE FORMULAS: a) (R)-N-(3,5-DICLOROPIRIDIN-2-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA, b) (R)-N-(5-CLOROTIAZOLO[5,4-b]PIRIDIN-2-IL)-4H-1'-AZASPIRO-OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA, c) (R)-N-(6-(1H-PIRAZOL-1-IL)PIRIMIDIN-4-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS, AGONISTAS Y AGONISTAS PARCIALES DEL RECEPTOR ALFA 7 NICOTINICO Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRALREFERRING TO COMPOUNDS DERIVED FROM QUINUCLIDINE FROM FORMULAS: a) (R) -N- (3,5-DICHLOROPYRIDIN-2-IL) -4H-1'-AZASPIRO [OXAZOL-5,3'-BICICLO [2.2.2] OCTAN ] -2-AMINE, b) (R) -N- (5-CHLOROTHIAZOLE [5,4-b] PYRIDIN-2-IL) -4H-1'-AZASPIRO-OXAZOL-5,3'-BICYCLE [2.2. 2] OCTAN] -2-AMINE, c) (R) -N- (6- (1H-PIRAZOL-1-IL) PYRIMIDIN-4-IL) -4H-1'-AZASPIRO [OXAZOL-5,3'- BICYCLE [2.2.2] OCTAN] -2-AMINE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE LIGANDS, AGONISTS AND PARTIAL AGONISTS OF THE ALPHA 7 NICOTINUM RECEPTOR AND ARE USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2012000594A PE20121183A1 (en) | 2009-10-29 | 2009-10-29 | COMPOUND (R) -N- (6- (1H-IMIDAZOL-1-IL) PYRIMIDIN-4-IL) -4H-1´-AZASPIRO [OXAZOL-5,3´-BICICLO [2.2.2] OCTAN] -2 -AMINE AS LIGANDS OF ACETYLCHOLINE NICOTINE ALPHA-7 RECEPTOR |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2012000594A PE20121183A1 (en) | 2009-10-29 | 2009-10-29 | COMPOUND (R) -N- (6- (1H-IMIDAZOL-1-IL) PYRIMIDIN-4-IL) -4H-1´-AZASPIRO [OXAZOL-5,3´-BICICLO [2.2.2] OCTAN] -2 -AMINE AS LIGANDS OF ACETYLCHOLINE NICOTINE ALPHA-7 RECEPTOR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121183A1 true PE20121183A1 (en) | 2012-09-10 |
Family
ID=47010067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000594A PE20121183A1 (en) | 2009-10-29 | 2009-10-29 | COMPOUND (R) -N- (6- (1H-IMIDAZOL-1-IL) PYRIMIDIN-4-IL) -4H-1´-AZASPIRO [OXAZOL-5,3´-BICICLO [2.2.2] OCTAN] -2 -AMINE AS LIGANDS OF ACETYLCHOLINE NICOTINE ALPHA-7 RECEPTOR |
Country Status (1)
| Country | Link |
|---|---|
| PE (1) | PE20121183A1 (en) |
-
2009
- 2009-10-29 PE PE2012000594A patent/PE20121183A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |