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PE20121467A1 - Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica - Google Patents

Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica

Info

Publication number
PE20121467A1
PE20121467A1 PE2012000851A PE2012000851A PE20121467A1 PE 20121467 A1 PE20121467 A1 PE 20121467A1 PE 2012000851 A PE2012000851 A PE 2012000851A PE 2012000851 A PE2012000851 A PE 2012000851A PE 20121467 A1 PE20121467 A1 PE 20121467A1
Authority
PE
Peru
Prior art keywords
pulmonary disease
chronic obstructive
obstructive pulmonary
aerosol formulation
composition
Prior art date
Application number
PE2012000851A
Other languages
English (en)
Inventor
Sauro Bonelli
Francesca Usberti
Enrico Zambelli
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42046446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121467(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20121467A1 publication Critical patent/PE20121467A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B65B31/04Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied
    • B65B31/06Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied the nozzle being arranged for insertion into, and withdrawal from, the mouth of a filled container and operating in conjunction with means for sealing the container mouth
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B65B31/10Adding propellants in solid form to aerosol containers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA EN FORMA DE SOLUCIONES EN AEROSOL QUE COMPRENDE: A) BROMURO DE GLICOPIRRONIO DISUELTO EN UN PROPULSOR DE HIDROFLUOROALCANO EN UNA CANTIDAD DE 0.005% A 0.14% P/P DE LA COMPOSICION; B) UN COSOLVENTE TAL COMO ETANOL; C) ACIDO CLORHIDRICO 1M EN UNA CANTIDAD DE 0.005 ug/ul A 1.0 ug/ul; D) UNO O MAS PRINCIPIOS ACTIVOS TALES COMO FUMARATO DE FORMOTEROL, DIPROPIONATO DE BECLOMETASONA, ENTRE OTROS. DICHA COMPOSICION MEJORA LA ESTABILIDAD DEL BROMURO DE GLICOPIRRONIO SIENDO UTIL EN EL TRATAMIENTO DE ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
PE2012000851A 2009-12-23 2010-12-22 Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica PE20121467A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09015980 2009-12-23

Publications (1)

Publication Number Publication Date
PE20121467A1 true PE20121467A1 (es) 2012-11-07

Family

ID=42046446

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000851A PE20121467A1 (es) 2009-12-23 2010-12-22 Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica

Country Status (31)

Country Link
US (5) US20110150783A1 (es)
EP (1) EP2515854B1 (es)
JP (1) JP5800829B2 (es)
KR (1) KR101747474B1 (es)
CN (1) CN102665680B (es)
AU (2) AU2010334858A1 (es)
CA (1) CA2785317C (es)
CL (1) CL2012001668A1 (es)
CO (1) CO6551734A2 (es)
CY (1) CY1115109T1 (es)
DK (1) DK2515854T3 (es)
EA (1) EA021604B1 (es)
ES (1) ES2464520T3 (es)
GE (1) GEP20166479B (es)
HR (1) HRP20140550T1 (es)
IL (1) IL220534A0 (es)
MA (1) MA33821B1 (es)
MX (1) MX340264B (es)
MY (1) MY156950A (es)
NZ (1) NZ600789A (es)
PE (1) PE20121467A1 (es)
PH (1) PH12012501063A1 (es)
PL (1) PL2515854T3 (es)
PT (1) PT2515854E (es)
RS (1) RS53355B (es)
SG (1) SG181870A1 (es)
SI (1) SI2515854T1 (es)
TN (1) TN2012000261A1 (es)
UA (1) UA106098C2 (es)
WO (1) WO2011076842A2 (es)
ZA (1) ZA201204613B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS53355B (sr) * 2009-12-23 2014-10-31 Chiesi Farmaceutici S.P.A. Aerosolna formulacija za copd (hronične obstruktivne pulmonarne bolesti)
CN102665678B (zh) * 2009-12-23 2014-07-02 奇斯药制品公司 用于copd的联合治疗
PE20121396A1 (es) 2009-12-23 2012-10-24 Chiesi Farma Spa Composicion farmaceutica que comprende bromuro de glicopirronio y formoterol
SI3089735T1 (sl) * 2013-12-30 2018-10-30 Chiesi Farmaceutici S.P.A. Sestavek stabilne aerosolne raztopine pod tlakom, ki vsebuje glikopironijev bromid in formoterol
PL3096737T3 (pl) * 2013-12-30 2018-08-31 Chiesi Farmaceutici S.P.A. Stabilna kompozycja w postaci ciśnieniowego roztworu aerozolowego kombinacji bromku glikopironium i formoterolu
US11559505B2 (en) 2015-12-04 2023-01-24 Mexichem Fluor S.A. De C.V. Pharmaceutical composition
CA3037092C (en) * 2016-09-19 2022-06-21 Mexichem Fluor S.A. De C.V. Stable pharmaceutical compositions comprising glycopyrrolate and 1,1-difluoroethane (hfa-152a) suitable for use in metered dose inhalers (mdis)
WO2020084549A1 (en) * 2018-10-25 2020-04-30 Glenmark Specialty S.A. Nebulization composition comprising glycopyrrolate and formoterol
AU2021314977B2 (en) 2020-07-31 2025-03-13 Chemo Research, S.L. Combination therapy for inhalation administration
CN112051346A (zh) * 2020-09-24 2020-12-08 珠海瑞思普利生物制药有限公司 一种同时测定茚达特罗和格隆溴铵含量的hplc方法
PE20240629A1 (es) 2020-10-09 2024-03-26 Chiesi Farm Spa Formulacion farmaceutica para inhalador presurizado de dosis medidas
JP2025517809A (ja) 2022-05-27 2025-06-10 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量噴霧吸入器のための医薬製剤

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US2956062A (en) 1959-02-26 1960-10-11 Robins Co Inc A H Esters of amino alcohols
RO117414B1 (ro) 1992-12-09 2002-03-29 Jager Paul D Waterbury Compozitie farmaceutica de aerosol in solutie
EP1102579B1 (de) 1998-08-04 2003-03-19 Jago Research Ag Medizinische aerosolformulierungen
IT1317720B1 (it) 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
HU230804B1 (hu) * 2000-05-22 2018-06-28 Chiesi Farmaceutici S.P.A Gyógyászati célú stabil aeroszol összetétel, inhalátor az aeroszol pontos adagolásához és eljárás ennek feltöltésére
US20060257324A1 (en) * 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
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HUE049426T2 (hu) 2002-03-01 2020-09-28 Chiesi Farm Spa Szuperfinom formoterolkészítmény
KR20050085650A (ko) 2002-12-16 2005-08-29 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 타이오트로피움 함유 hfc 용액 제형
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PE20121396A1 (es) * 2009-12-23 2012-10-24 Chiesi Farma Spa Composicion farmaceutica que comprende bromuro de glicopirronio y formoterol
CN102665678B (zh) 2009-12-23 2014-07-02 奇斯药制品公司 用于copd的联合治疗
RS53355B (sr) * 2009-12-23 2014-10-31 Chiesi Farmaceutici S.P.A. Aerosolna formulacija za copd (hronične obstruktivne pulmonarne bolesti)
ES2628891T3 (es) * 2010-08-03 2017-08-04 Chiesi Farmaceutici S.P.A. Formulación farmacéutica que comprende un inhibidor de fosfodiesterasa
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PL3096737T3 (pl) 2013-12-30 2018-08-31 Chiesi Farmaceutici S.P.A. Stabilna kompozycja w postaci ciśnieniowego roztworu aerozolowego kombinacji bromku glikopironium i formoterolu
SI3089735T1 (sl) * 2013-12-30 2018-10-30 Chiesi Farmaceutici S.P.A. Sestavek stabilne aerosolne raztopine pod tlakom, ki vsebuje glikopironijev bromid in formoterol

Also Published As

Publication number Publication date
PT2515854E (pt) 2014-05-27
NZ600789A (en) 2014-09-26
MX2012006879A (es) 2012-07-04
CN102665680B (zh) 2014-07-30
US20230157951A1 (en) 2023-05-25
TN2012000261A1 (en) 2013-12-12
WO2011076842A3 (en) 2011-12-01
GEP20166479B (en) 2016-05-25
US20150306026A1 (en) 2015-10-29
US12357568B2 (en) 2025-07-15
JP2013515695A (ja) 2013-05-09
IL220534A0 (en) 2012-08-30
US20110150783A1 (en) 2011-06-23
DK2515854T3 (da) 2014-05-26
US11590074B2 (en) 2023-02-28
ZA201204613B (en) 2013-09-25
CO6551734A2 (es) 2012-10-31
SI2515854T1 (sl) 2014-07-31
PH12012501063A1 (en) 2013-02-04
KR101747474B1 (ko) 2017-06-14
CN102665680A (zh) 2012-09-12
PL2515854T3 (pl) 2014-08-29
ES2464520T3 (es) 2014-06-03
UA106098C2 (uk) 2014-07-25
CY1115109T1 (el) 2016-12-14
WO2011076842A2 (en) 2011-06-30
EA021604B1 (ru) 2015-07-30
US20210000738A1 (en) 2021-01-07
HRP20140550T1 (hr) 2014-07-18
MX340264B (es) 2016-07-04
KR20120120160A (ko) 2012-11-01
RS53355B (sr) 2014-10-31
BR112012015336A2 (pt) 2016-03-15
EA201290374A1 (ru) 2013-01-30
HK1174568A1 (en) 2013-06-14
CA2785317A1 (en) 2011-06-30
SG181870A1 (en) 2012-07-30
EP2515854B1 (en) 2014-03-19
EP2515854A2 (en) 2012-10-31
MA33821B1 (fr) 2012-12-03
CA2785317C (en) 2018-02-27
AU2016234894B2 (en) 2018-02-22
US10806701B2 (en) 2020-10-20
CL2012001668A1 (es) 2012-12-07
US20250262151A1 (en) 2025-08-21
AU2010334858A1 (en) 2012-07-12
MY156950A (en) 2016-04-15
JP5800829B2 (ja) 2015-10-28
AU2016234894A1 (en) 2016-10-13

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