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PE20120126A1 - Nuevas bencenosulfonamidas como bloqueadores de canales de calcio - Google Patents

Nuevas bencenosulfonamidas como bloqueadores de canales de calcio

Info

Publication number
PE20120126A1
PE20120126A1 PE2011001348A PE2011001348A PE20120126A1 PE 20120126 A1 PE20120126 A1 PE 20120126A1 PE 2011001348 A PE2011001348 A PE 2011001348A PE 2011001348 A PE2011001348 A PE 2011001348A PE 20120126 A1 PE20120126 A1 PE 20120126A1
Authority
PE
Peru
Prior art keywords
benzenosulphonamides
calcium channel
channel blockers
benzenosulfonamide
ylcarbonyl
Prior art date
Application number
PE2011001348A
Other languages
English (en)
Inventor
Qingwei Zhan
Andrew O Stewart
Zhiren Xia
Michael F Jarvis
Victoria E Scott
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796157&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120126(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of PE20120126A1 publication Critical patent/PE20120126A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE BENCENOSULFONAMIDAS DE FORMULAS (I) Y (II) DONDE R1 Y R2 SON CADA UNO X E Y, EN DONDE X ES UN COMPUESTO DE FORMULA (i) O (ii) DONDE m Y n SON CADA UNO 1 O 2; G1 ES AZETIDINILO, PIRROLIDINILO, MORFOLINILO, ENTRE OTROS; Y ES NRcAr1, NRcCH(Ar1)2, ENTRE OTROS, EN DONDE Ar1 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON ALCOXI, ALQUILO, CN, ENTRE OTROS; Rc ES H O ALQUILO; R3, R4, R5 Y R6 SON CADA UNO H, ALCOXI, ALQUILO O HALOGENO. SON COMPUESTOS PREFERIDOS: 3-[(8aR)-HEXAHIDROPIRROLO[1,2-a]PIRAZIN-2(1H)-ILCARBONIL]-N-[4-(TRIFLUOROMETIL)FENIL]BENCENOSULFONAMIDA; N-(2-FLUOROFENIL)-3-[(8aR)-HEXAHIDROPIRROLO[1,2-a]PIRAZIN-2(1H)-ILCARBONIL]BENCENOSULFONAMIDA; N-(3-FLUOROFENIL)-3-[(8aS)-HEXAHIDROPIRROLO[1,2-a]PIRAZIN-2(1H)-ILCARBONIL]BENCENOSULFONAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON BLOQUEADORES DE CANALES DE CALCIO SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR, EPILEPSIA, DEPRESION, ANSIEDAD, MIGRANA
PE2011001348A 2009-01-15 2010-01-14 Nuevas bencenosulfonamidas como bloqueadores de canales de calcio PE20120126A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14489909P 2009-01-15 2009-01-15

Publications (1)

Publication Number Publication Date
PE20120126A1 true PE20120126A1 (es) 2012-03-18

Family

ID=41796157

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001348A PE20120126A1 (es) 2009-01-15 2010-01-14 Nuevas bencenosulfonamidas como bloqueadores de canales de calcio

Country Status (22)

Country Link
US (3) US8101614B2 (es)
EP (1) EP2382191B1 (es)
JP (1) JP5619773B2 (es)
KR (1) KR20110110299A (es)
CN (1) CN102282131B (es)
AR (1) AR077440A1 (es)
AU (1) AU2010204753A1 (es)
BR (1) BRPI1005675A2 (es)
CA (1) CA2747752A1 (es)
CL (1) CL2011001714A1 (es)
CO (1) CO6400194A2 (es)
DO (1) DOP2011000217A (es)
ES (1) ES2527467T3 (es)
IL (1) IL213500A0 (es)
MX (1) MX337190B (es)
PE (1) PE20120126A1 (es)
RU (1) RU2011134052A (es)
SG (1) SG172308A1 (es)
TW (1) TW201028421A (es)
UY (1) UY32384A (es)
WO (1) WO2010083264A1 (es)
ZA (1) ZA201104715B (es)

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US8101614B2 (en) 2012-01-24
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