PE20110384A1 - DERIVATIVES OF ALKYLTIAZOLES CARBAMATES AND THEIR PREPARATION - Google Patents
DERIVATIVES OF ALKYLTIAZOLES CARBAMATES AND THEIR PREPARATIONInfo
- Publication number
- PE20110384A1 PE20110384A1 PE2011000070A PE2011000070A PE20110384A1 PE 20110384 A1 PE20110384 A1 PE 20110384A1 PE 2011000070 A PE2011000070 A PE 2011000070A PE 2011000070 A PE2011000070 A PE 2011000070A PE 20110384 A1 PE20110384 A1 PE 20110384A1
- Authority
- PE
- Peru
- Prior art keywords
- thiazol
- cyane
- ilmethyl
- tetrahydro
- bipyridinyl
- Prior art date
Links
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 abstract 4
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- AKZWRTCWNXHHFR-PDIZUQLASA-N [(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(5S)-5-benzyl-3-[(2R)-2-carbamoyloxy-2,3-dihydro-1H-inden-1-yl]-4-oxo-3H-pyrrol-5-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound NC(=O)O[C@@H]1Cc2ccccc2C1C1C=N[C@](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CCOC2)(Cc2ccccc2)C1=O AKZWRTCWNXHHFR-PDIZUQLASA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical group [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Virology (AREA)
- Diabetes (AREA)
Abstract
REFERIDA A UN DERIVADO DE CARBAMATO DE FORMULA (I), DONDE R2 ES H, F, OH, CIANO, TRIFLUOROMETILO, ENTRE OTROS; n ES UN ENTERO DE 1 A 3; m ES 1 O 2; A ES UN ENLACE COVALENTE O UN GRUPO ALQUILENO C1-C8; R1 ES R5 OPCIONALMENTE SUSTITUIDO CON R6 Y/O R7; R5 ES FENILO, PIRIDINILO, PIRIDACINILO, ENTRE OTROS; R6 ES HALOGENO, CIANO, NITRO, OH, ENTRE OTROS; R7 ES FURANILO, PIRROLILO, TIENILO, ENTRE OTROS; R3 ES H, F, ALQUILO C1-C6, TRIFLUOROMETILO; R4 ES TIAZOL OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C6, CIANO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6'-[TIOFEN-3-IL-3,4,5,6-TETRAHIDRO-2H-[1,2']BIPIRIDINIL-4-IL]-METILCARBAMATO DE TIAZOL-4-ILMETILO, 6'-(1-ISOBUTIL-1H-PIRAZOL-4-IL)-3,4,5,6-TETRAHIDRO-2H-[1,2']BIPIRIDINIL-4-IL]-METILCARBAMATO DE TIAZOL-4-ILMETILO, 2-(5''-FLUORO-3,4,5,6-TETRAHIDRO-2H-[1,2';6',3'']TERPIRIDIN-4-IL)-ETILCARBAMATO DE TIAZOL-2-ILMETILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ENZIMA FAAH Y SON UTILES EN EL TRATAMIENTO DEL DOLOR, ENFERMEDADES NEURODEGENERATIVAS, ENFERMEDADES ALERGICAS, ENTRE OTROSREFERRED TO A CARBAMATE DERIVATIVE OF FORMULA (I), WHERE R2 IS H, F, OH, CYANE, TRIFLUOROMETHYL, AMONG OTHERS; n IS AN INTEGER FROM 1 TO 3; m IS 1 O 2; A IS A COVALENT LINK OR A C1-C8 ALKYLENE GROUP; R1 IS R5 OPTIONALLY REPLACED WITH R6 AND / OR R7; R5 IS PHENYL, PYRIDINYL, PYRIDACINYL, AMONG OTHERS; R6 IS HALOGEN, CYANE, NITRO, OH, AMONG OTHERS; R7 IS FURANILO, PIRROLYL, TIENILO, AMONG OTHERS; R3 IS H, F, C1-C6 ALKYL, TRIFLUOROMETHYL; R4 IS THIAZOL OPTIONALLY SUBSTITUTED WITH C1-C6 ALKYL, CYANE, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 6 '- [THIOFEN-3-IL-3,4,5,6-TETRAHYDRO-2H- [1,2'] BIPYRIDINYL-4-IL] -THIAZOL-4-ILMETHYL METHYLCARBAMATE, 6'- (1-ISOBUTYL-1H-PYRAZOLE-4-IL) -3,4,5,6-TETRAHYDRO-2H- [1,2 '] BIPYRIDINYL-4-IL] -THIAZOL-4-ILMETHYL METHYLCARBAMATE, 2- ( 5 "-FLUORO-3,4,5,6-TETRAHYDRO-2H- [1,2 '; 6', 3"] TERPYRIDIN-4-IL) -THIAZOL-2-ILMETHYL ETHYLCARBAMATE, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS INHIBIT THE FAAH ENZYME AND ARE USEFUL IN THE TREATMENT OF PAIN, NEURODEGENERATIVE DISEASES, ALLERGIC DISEASES, AMONG OTHERS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0804179A FR2934265B1 (en) | 2008-07-23 | 2008-07-23 | ALKYLTHIAZOLE CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110384A1 true PE20110384A1 (en) | 2011-07-01 |
Family
ID=40289184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000070A PE20110384A1 (en) | 2008-07-23 | 2009-07-21 | DERIVATIVES OF ALKYLTIAZOLES CARBAMATES AND THEIR PREPARATION |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8912218B2 (en) |
| EP (1) | EP2344486B1 (en) |
| JP (1) | JP5452594B2 (en) |
| KR (1) | KR20110034020A (en) |
| CN (1) | CN102164920B (en) |
| AR (1) | AR072593A1 (en) |
| AU (1) | AU2009274355B2 (en) |
| BR (1) | BRPI0916385A2 (en) |
| CA (1) | CA2731789C (en) |
| CL (1) | CL2011000147A1 (en) |
| CO (1) | CO6351789A2 (en) |
| CY (1) | CY1114519T1 (en) |
| DK (1) | DK2344486T3 (en) |
| EA (1) | EA018995B1 (en) |
| ES (1) | ES2413304T3 (en) |
| FR (1) | FR2934265B1 (en) |
| HR (1) | HRP20130585T1 (en) |
| IL (1) | IL210747A0 (en) |
| MA (1) | MA32579B1 (en) |
| MX (1) | MX2011000882A (en) |
| PE (1) | PE20110384A1 (en) |
| PL (1) | PL2344486T3 (en) |
| PT (1) | PT2344486E (en) |
| SI (1) | SI2344486T1 (en) |
| SM (1) | SMT201300080B (en) |
| TW (1) | TW201008937A (en) |
| UY (1) | UY32004A (en) |
| WO (1) | WO2010010288A2 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2938537B1 (en) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | ALKYL-HETEROCYCLE CARBAMATE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
| FR2941696B1 (en) * | 2009-02-05 | 2011-04-15 | Sanofi Aventis | AZASPIRANYL-ALKYLCARBAMATES DERIVATIVES OF 5-CHAIN HETEROCYCLES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| FR2945533B1 (en) * | 2009-05-12 | 2011-05-27 | Sanofi Aventis | CYCLOPENTA® C! PYRROLYL-ALKYLCARBAMATE DERIVATIVES OF 5-CHAIN HETEROCYCLES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| FR2945534B1 (en) * | 2009-05-12 | 2012-11-16 | Sanofi Aventis | CYCLOPENTAL [c] PYRROLE-2-CARBOXYLATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| WO2011085216A2 (en) | 2010-01-08 | 2011-07-14 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating parkinson's disease and restless legs syndrome |
| WO2011123719A2 (en) | 2010-03-31 | 2011-10-06 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating abdominal, visceral and pelvic pain |
| BR112013006016A2 (en) | 2010-09-15 | 2016-06-07 | Hoffmann La Roche | azabenzothiazole compounds, compositions and methods of use |
| DE102012018115A1 (en) | 2012-09-13 | 2014-03-13 | Matthias Lehr | New aryl-N-(arylalkyl) carbamate compounds, used to prepare pharmaceutical composition for prophylactic and/or therapeutic treatment of diseases including e.g. acute and chronic neurogenic pain, and neurological and psychiatric diseases |
| DE102013016573A1 (en) | 2013-10-04 | 2015-04-09 | Matthias Lehr | 1-Tetrazolylpropan-2-ones as inhibitors of cytosolic phospholipase A2 and fatty acid amide hydrolase, in particular suitable for topical application |
| WO2020048831A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048830A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| CN113880774B (en) * | 2020-07-02 | 2023-12-08 | 沈阳中化农药化工研发有限公司 | A kind of preparation method of phenylisoxazoline compounds |
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| GB0417801D0 (en) * | 2004-08-10 | 2004-09-15 | Novartis Ag | Organic compounds |
| NZ552501A (en) * | 2004-08-11 | 2010-03-26 | Kyorin Seiyaku Kk | Novel cyclic aminobenzoic acid derivative |
| AR067354A1 (en) * | 2007-06-29 | 2009-10-07 | Sunesis Pharmaceuticals Inc | USEFUL COMPOUNDS AS INHIBITORS OF RAF QUINASA |
| FR2938537B1 (en) * | 2008-11-14 | 2012-10-26 | Sanofi Aventis | ALKYL-HETEROCYCLE CARBAMATE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
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