PE20110154A1 - Derivados de (4-(fenil)-3,6-dihidropiridin-1-il)-(piperazinil con enlace puente)-1-alcanona y ((fenil)-2,5-dihidropirrol-1-il)-(piperazinil con enlace puente)-1-alcanona como inhibidores de p75 - Google Patents
Derivados de (4-(fenil)-3,6-dihidropiridin-1-il)-(piperazinil con enlace puente)-1-alcanona y ((fenil)-2,5-dihidropirrol-1-il)-(piperazinil con enlace puente)-1-alcanona como inhibidores de p75Info
- Publication number
- PE20110154A1 PE20110154A1 PE2010001120A PE2010001120A PE20110154A1 PE 20110154 A1 PE20110154 A1 PE 20110154A1 PE 2010001120 A PE2010001120 A PE 2010001120A PE 2010001120 A PE2010001120 A PE 2010001120A PE 20110154 A1 PE20110154 A1 PE 20110154A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- piperazinil
- trifluoromethyl
- alcanone
- pyridin
- Prior art date
Links
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 PIPERAZINYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- JTZSFNHHVULOGJ-UHFFFAOYSA-N 3-(trifluoromethyl)pyridine Chemical group FC(F)(F)C1=CC=CN=C1 JTZSFNHHVULOGJ-UHFFFAOYSA-N 0.000 abstract 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 1
- 238000006471 dimerization reaction Methods 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DERIVADO DE (PIPERAZINILO CON ENLACES PUENTE)-1-ALCANONA DE FORMULA (I) DONDE m ES 0-1; A Y B SON CADA UNO H O FENILO SUSTITUIDO POR R1 Y R2, TENIENDO EN CUENTA QUE SI A ES H; B ES FENILO DISUSTITUIDO Y VICEVERSA; R1 ES HALOGENO, ALQUILO C1-C4, TRIFLUOROMETIL, ENTRE OTROS; R2 ES H, HALOGENO, ALQUILO C1-C4, TRIFLUOROMETIL, ALCOXI C1-C4, CONH2, ENTRE OTROS; W ES UN HETEROCICLO COMO SE MUESTRA EN LA FIGURA; n ES 1-2; R5 ES 3-TRIFLUOROMETIL-PIRIDINA, PIRAZINA-2-IL, 5-BROMOPIRIMIDIN-2-IL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 1-[4-(3-TRIFLUOROMETIL-FENIL)-3,6-DIHIDRO-2H-PIRIDIN-1-IL]-2-[8-(5-TRIFLUOROMETIL-PIRIDIN-2-IL)-3,8-DIAZA-BICICLO[3.2.1]OCT-3-IL]ETANONA; 1-[4-(4-CLORO-FENIL)-3,6-DIHIDRO-2H-PIRIDIN-1-IL]-2-(8-PIRIMIDIN-2-IL-3,8-DIAZA-BICICLO[3.2.1]OCT-3-IL)-ETANONA; ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES INHIBIDOR DE LA DIMERIZACION DEL RECEPTOR p75NTR (NEUTROFINAS) UTIL EN EL TRATAMIENTO DE EPILEPSIA, ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0803299A FR2932482B1 (fr) | 2008-06-13 | 2008-06-13 | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110154A1 true PE20110154A1 (es) | 2011-03-14 |
Family
ID=40305395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001120A PE20110154A1 (es) | 2008-06-13 | 2009-06-12 | Derivados de (4-(fenil)-3,6-dihidropiridin-1-il)-(piperazinil con enlace puente)-1-alcanona y ((fenil)-2,5-dihidropirrol-1-il)-(piperazinil con enlace puente)-1-alcanona como inhibidores de p75 |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US8193190B2 (es) |
| EP (1) | EP2297148B8 (es) |
| JP (1) | JP5476373B2 (es) |
| KR (1) | KR101642526B1 (es) |
| CN (1) | CN102124006B (es) |
| AR (1) | AR072103A1 (es) |
| AT (1) | ATE540039T1 (es) |
| AU (1) | AU2009259121B2 (es) |
| BR (1) | BRPI0915126B8 (es) |
| CA (1) | CA2727669C (es) |
| CL (1) | CL2010001429A1 (es) |
| CO (1) | CO6280535A2 (es) |
| CR (1) | CR11832A (es) |
| CY (1) | CY1112610T1 (es) |
| DK (1) | DK2297148T3 (es) |
| DO (2) | DOP2010000380A (es) |
| EA (1) | EA019074B1 (es) |
| EC (1) | ECSP10010672A (es) |
| ES (1) | ES2379685T3 (es) |
| FR (1) | FR2932482B1 (es) |
| HR (1) | HRP20120290T1 (es) |
| IL (1) | IL209902A (es) |
| JO (1) | JO2774B1 (es) |
| MA (1) | MA32474B1 (es) |
| MX (1) | MX2010013695A (es) |
| MY (1) | MY150988A (es) |
| NI (1) | NI201000215A (es) |
| NZ (1) | NZ589840A (es) |
| PE (1) | PE20110154A1 (es) |
| PL (1) | PL2297148T3 (es) |
| PT (1) | PT2297148E (es) |
| RS (1) | RS52262B (es) |
| SI (1) | SI2297148T1 (es) |
| SV (1) | SV2010003755A (es) |
| TW (1) | TWI432433B (es) |
| UA (1) | UA101979C2 (es) |
| UY (1) | UY31893A (es) |
| WO (1) | WO2009150388A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2931223B1 (fr) | 2008-05-16 | 2010-08-20 | Air Liquide | Dispositif distributeur de gaz sous pression, ensemble comprenant un tel dispositif et dispositif de commande, recipient pourvu d'un tel dispositif distributeur |
| FR2932481B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
| FR2953836B1 (fr) * | 2009-12-14 | 2012-03-16 | Sanofi Aventis | Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2953839A1 (fr) | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| EP2606894A1 (en) * | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3236243A1 (de) * | 1982-09-30 | 1984-04-05 | Merck Patent Gmbh, 6100 Darmstadt | Schwefelhaltige indolderivate |
| FR2744448B1 (fr) * | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| US6613942B1 (en) * | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| AU749271B2 (en) * | 1997-07-01 | 2002-06-20 | Agouron Pharmaceuticals, Inc. | Glucagon antagonists/inverse agonists |
| EP1165522A1 (en) | 1999-04-06 | 2002-01-02 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic thio substituted pyrimidines |
| UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| FR2862967B1 (fr) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique |
| FR2862968B1 (fr) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique |
| FR2932481B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
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2008
- 2008-06-13 FR FR0803299A patent/FR2932482B1/fr not_active Expired - Fee Related
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2009
- 2009-06-04 JO JO2009204A patent/JO2774B1/en active
- 2009-06-11 TW TW098119564A patent/TWI432433B/zh active
- 2009-06-11 AR ARP090102110A patent/AR072103A1/es active IP Right Grant
- 2009-06-12 MY MYPI20105850 patent/MY150988A/en unknown
- 2009-06-12 BR BRPI0915126A patent/BRPI0915126B8/pt active Search and Examination
- 2009-06-12 RS RS20120137A patent/RS52262B/sr unknown
- 2009-06-12 UA UAA201100370A patent/UA101979C2/ru unknown
- 2009-06-12 JP JP2011513038A patent/JP5476373B2/ja active Active
- 2009-06-12 HR HR20120290T patent/HRP20120290T1/hr unknown
- 2009-06-12 WO PCT/FR2009/051118 patent/WO2009150388A1/fr not_active Ceased
- 2009-06-12 CN CN200980131366.XA patent/CN102124006B/zh active Active
- 2009-06-12 AT AT09761939T patent/ATE540039T1/de active
- 2009-06-12 EA EA201170016A patent/EA019074B1/ru not_active IP Right Cessation
- 2009-06-12 DK DK09761939.9T patent/DK2297148T3/da active
- 2009-06-12 CA CA2727669A patent/CA2727669C/fr active Active
- 2009-06-12 PE PE2010001120A patent/PE20110154A1/es not_active Application Discontinuation
- 2009-06-12 MX MX2010013695A patent/MX2010013695A/es active IP Right Grant
- 2009-06-12 PL PL09761939T patent/PL2297148T3/pl unknown
- 2009-06-12 SI SI200930220T patent/SI2297148T1/sl unknown
- 2009-06-12 PT PT09761939T patent/PT2297148E/pt unknown
- 2009-06-12 KR KR1020117000792A patent/KR101642526B1/ko active Active
- 2009-06-12 EP EP09761939A patent/EP2297148B8/fr active Active
- 2009-06-12 ES ES09761939T patent/ES2379685T3/es active Active
- 2009-06-12 NZ NZ589840A patent/NZ589840A/xx not_active IP Right Cessation
- 2009-06-12 UY UY0001031893A patent/UY31893A/es not_active Application Discontinuation
- 2009-06-12 AU AU2009259121A patent/AU2009259121B2/en active Active
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2010
- 2010-12-08 CR CR11832A patent/CR11832A/es unknown
- 2010-12-08 DO DO2010000380A patent/DOP2010000380A/es unknown
- 2010-12-09 SV SV2010003755A patent/SV2010003755A/es unknown
- 2010-12-09 IL IL209902A patent/IL209902A/en active IP Right Grant
- 2010-12-10 NI NI201000215A patent/NI201000215A/es unknown
- 2010-12-10 EC EC2010010672A patent/ECSP10010672A/es unknown
- 2010-12-13 CL CL2010001429A patent/CL2010001429A1/es unknown
- 2010-12-13 CO CO10156029A patent/CO6280535A2/es active IP Right Grant
- 2010-12-13 US US12/966,413 patent/US8193190B2/en active Active
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2011
- 2011-01-13 MA MA33517A patent/MA32474B1/fr unknown
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2012
- 2012-04-04 CY CY20121100339T patent/CY1112610T1/el unknown
- 2012-05-17 US US13/473,885 patent/US8519143B2/en active Active
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2013
- 2013-06-04 DO DO2013000124A patent/DOP2013000124A/es unknown
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