PE20100051A1 - Nuevo procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-oa y aplicacion en la sintesis de ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable - Google Patents
Nuevo procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-oa y aplicacion en la sintesis de ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptableInfo
- Publication number
- PE20100051A1 PE20100051A1 PE2009000809A PE2009000809A PE20100051A1 PE 20100051 A1 PE20100051 A1 PE 20100051A1 PE 2009000809 A PE2009000809 A PE 2009000809A PE 2009000809 A PE2009000809 A PE 2009000809A PE 20100051 A1 PE20100051 A1 PE 20100051A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- synthesis
- dimetoxi
- dihidro
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title abstract 2
- 229960003825 ivabradine Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical compound C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 abstract 1
- CZLMRJZAHXYRIX-UHFFFAOYSA-N 1,3-dioxepane Chemical compound C1CCOCOC1 CZLMRJZAHXYRIX-UHFFFAOYSA-N 0.000 abstract 1
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 230000001351 cycling effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN PROCEDIMIENTO PARA LA SINTESIS DE 7,8-DIMETOXI-1,3-DIHIDRO-2H-3-BENZAZEPIN-2-ONA DE FORMULA (I), DONDE DICHO PROCEDIMIENTO CONSISTE EN TRANSFORMAR EL ACIDO (3,4-DIMETOXIFENIL)ACETICO CON CLORURO DE TIONILO, EN PRESENCIA DE UN DISOLVENTE DE DICLOROMETANO Y A UNA TEMPERATURA ENTRE 20ºC A 40ºC, EN UN COMPUESTO DE FORMULA (VI), SEGUIDO DE UNA CONDENSACION DEL COMPUESTO (VI) CON UN COMPUESTO H2N-CH2-CHR1R2, PARA DAR LUGAR A UN COMPUESTO DE FORMULA (V), EL CUAL SE SOMETE A UNA CICLACION EN MEDIO ACIDO DADO POR EL ACIDO SULFURICO CONCENTRADO, QUE LUEGO DE UN AISLAMIENTO SE OBTIENE EL COMPUESTO DE FORMULA (I). X ES HALOGENO O UN GRUPO OCOR3; R3 ES ALQUILO C1-C6, FENILO, BENCILO, ENTRE OTROS; R1 Y R2 SON ALCOXI C1-C6 O JUNTOS AL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN CICLO 1,3-DIOXANO, 1,3-DIOXOLANO O 1,3-DIOXEPANO. DICHO COMPUESTO DE FORMULA (I) ES UN INTERMEDIARIO PARA LA FORMACION DE IVABRADINA O SALES DE LA MISMA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0803452A FR2932800B1 (fr) | 2008-06-20 | 2008-06-20 | Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20100051A1 true PE20100051A1 (es) | 2010-02-06 |
Family
ID=40347797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000809A PE20100051A1 (es) | 2008-06-20 | 2009-06-09 | Nuevo procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-oa y aplicacion en la sintesis de ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7928223B2 (es) |
| EP (1) | EP2135861B2 (es) |
| JP (1) | JP5216697B2 (es) |
| KR (1) | KR101119296B1 (es) |
| CN (1) | CN101607939B (es) |
| AR (1) | AR072175A1 (es) |
| AU (1) | AU2009202314B2 (es) |
| BR (1) | BRPI0902105A2 (es) |
| CA (1) | CA2668524C (es) |
| CL (1) | CL2009001414A1 (es) |
| CY (1) | CY1115623T1 (es) |
| DK (1) | DK2135861T4 (es) |
| EA (1) | EA017333B1 (es) |
| ES (1) | ES2522625T5 (es) |
| FR (1) | FR2932800B1 (es) |
| GE (1) | GEP20125407B (es) |
| HR (1) | HRP20140928T4 (es) |
| JO (1) | JO3806B1 (es) |
| MA (1) | MA31071B1 (es) |
| ME (1) | ME00814B (es) |
| MX (1) | MX2009006288A (es) |
| MY (1) | MY146245A (es) |
| NZ (1) | NZ577540A (es) |
| PE (1) | PE20100051A1 (es) |
| PL (1) | PL2135861T5 (es) |
| PT (1) | PT2135861E (es) |
| RS (1) | RS53495B2 (es) |
| SA (1) | SA109300396B1 (es) |
| SG (1) | SG158026A1 (es) |
| SI (1) | SI2135861T2 (es) |
| TW (1) | TWI374134B (es) |
| UA (1) | UA107779C2 (es) |
| UY (1) | UY31883A (es) |
| WO (1) | WO2009153461A2 (es) |
| ZA (1) | ZA200904316B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8212026B2 (en) * | 2007-05-30 | 2012-07-03 | Ind-Swift Laboratories Limited | Process for the preparation of ivabradine hydrochloride and polymorph thereof |
| CN101774969B (zh) * | 2009-01-13 | 2012-07-04 | 江苏恒瑞医药股份有限公司 | 硫酸伊伐布雷定及其i型结晶的制备方法 |
| WO2011098582A2 (en) | 2010-02-12 | 2011-08-18 | Krka, D.D., Novo Mesto | Novel forms of ivabradine hydrochloride |
| FR2956401B1 (fr) | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| WO2011104723A2 (en) * | 2010-02-23 | 2011-09-01 | Ind-Swift Laboratories Limited | Acid addition salts of ivabradine and preparation thereof |
| HUP1000245A2 (en) * | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
| FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR3003859B1 (fr) * | 2013-03-26 | 2015-03-13 | Servier Lab | "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine" |
| HU230826B1 (hu) * | 2014-11-19 | 2018-07-30 | Richter Gedeon Nyrt. | Eljárás benzazepin származékok előállítására |
| EP3101010A1 (en) | 2015-06-03 | 2016-12-07 | Urquima S.A. | New method for the preparation of highly pure ivabradine base and salts thereof |
| CN108424389A (zh) * | 2017-02-13 | 2018-08-21 | 浙江京新药业股份有限公司 | 一种伊伐布雷定杂质的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
| ZA84758B (en) * | 1983-02-04 | 1985-09-25 | Lilly Co Eli | Benzazepines |
| DE3343801A1 (de) * | 1983-12-03 | 1985-06-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3418271A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0204349A3 (de) * | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| UA77165C2 (en) * | 2000-11-17 | 2006-11-15 | Lilly Co Eli | (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition |
| WO2002074746A1 (en) * | 2001-03-16 | 2002-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Benzazepine derivatives |
| EP1680127B1 (en) * | 2003-10-23 | 2008-10-15 | F. Hoffmann-La Roche Ag | Benzazepine derivatives as mao-b inhibitors |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| NZ565111A (en) * | 2005-07-15 | 2011-10-28 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
-
2008
- 2008-06-20 FR FR0803452A patent/FR2932800B1/fr active Active
-
2009
- 2009-06-08 SG SG200903913-2A patent/SG158026A1/en unknown
- 2009-06-09 NZ NZ577540A patent/NZ577540A/en unknown
- 2009-06-09 PE PE2009000809A patent/PE20100051A1/es not_active Application Discontinuation
- 2009-06-09 CA CA2668524A patent/CA2668524C/fr active Active
- 2009-06-09 UY UY0001031883A patent/UY31883A/es unknown
- 2009-06-10 AU AU2009202314A patent/AU2009202314B2/en active Active
- 2009-06-11 MY MYPI20092391A patent/MY146245A/en unknown
- 2009-06-12 MX MX2009006288A patent/MX2009006288A/es active IP Right Grant
- 2009-06-15 CL CL2009001414A patent/CL2009001414A1/es unknown
- 2009-06-15 MA MA31996A patent/MA31071B1/fr unknown
- 2009-06-17 GE GEAP200911317A patent/GEP20125407B/en unknown
- 2009-06-17 US US12/456,437 patent/US7928223B2/en active Active
- 2009-06-17 SA SA109300396A patent/SA109300396B1/ar unknown
- 2009-06-18 ME MEP-2009-230A patent/ME00814B/me unknown
- 2009-06-18 AR ARP090102210A patent/AR072175A1/es active IP Right Grant
- 2009-06-18 JO JOP/2009/0217A patent/JO3806B1/ar active
- 2009-06-18 UA UAA200906350A patent/UA107779C2/ru unknown
- 2009-06-19 KR KR1020090054857A patent/KR101119296B1/ko active Active
- 2009-06-19 JP JP2009145931A patent/JP5216697B2/ja active Active
- 2009-06-19 DK DK09290466.3T patent/DK2135861T4/da active
- 2009-06-19 PL PL09290466.3T patent/PL2135861T5/pl unknown
- 2009-06-19 ES ES09290466T patent/ES2522625T5/es active Active
- 2009-06-19 ZA ZA200904316A patent/ZA200904316B/xx unknown
- 2009-06-19 EP EP09290466.3A patent/EP2135861B2/fr active Active
- 2009-06-19 WO PCT/FR2009/000738 patent/WO2009153461A2/fr not_active Ceased
- 2009-06-19 RS RS20140439A patent/RS53495B2/sr unknown
- 2009-06-19 TW TW098120697A patent/TWI374134B/zh active
- 2009-06-19 CN CN2009101504175A patent/CN101607939B/zh active Active
- 2009-06-19 SI SI200931020T patent/SI2135861T2/sl unknown
- 2009-06-19 PT PT92904663T patent/PT2135861E/pt unknown
- 2009-06-19 BR BRPI0902105-1A patent/BRPI0902105A2/pt not_active Application Discontinuation
- 2009-06-19 EA EA200900707A patent/EA017333B1/ru unknown
-
2014
- 2014-09-29 HR HRP20140928TT patent/HRP20140928T4/hr unknown
- 2014-10-14 CY CY20141100834T patent/CY1115623T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |