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PE20091206A1 - Sales del acido 4-[4-[(2r)-3-[4-amino-3- cloro-5-(trifluorometil)fenil]-1-oxo-2[[[4-(1,2,4,5-tetrahidro-2-oxo-3h-1,3-benzodiazepin-3-il)-1-piperidinil]carbonil]oxi]propil]-1-piperazinil]-piperidin-1-acetico como antagonista de cgrp (peptido relaciona - Google Patents

Sales del acido 4-[4-[(2r)-3-[4-amino-3- cloro-5-(trifluorometil)fenil]-1-oxo-2[[[4-(1,2,4,5-tetrahidro-2-oxo-3h-1,3-benzodiazepin-3-il)-1-piperidinil]carbonil]oxi]propil]-1-piperazinil]-piperidin-1-acetico como antagonista de cgrp (peptido relaciona

Info

Publication number
PE20091206A1
PE20091206A1 PE2008001691A PE2008001691A PE20091206A1 PE 20091206 A1 PE20091206 A1 PE 20091206A1 PE 2008001691 A PE2008001691 A PE 2008001691A PE 2008001691 A PE2008001691 A PE 2008001691A PE 20091206 A1 PE20091206 A1 PE 20091206A1
Authority
PE
Peru
Prior art keywords
oxo
benzodiazepin
piperidin
piperazinyl
piperidinyl
Prior art date
Application number
PE2008001691A
Other languages
English (en)
Inventor
Kathrin Pachur
Uwe Joerg Ries
Sonja Sproll
Ulrike Werthmann
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40032737&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091206(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20091206A1 publication Critical patent/PE20091206A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A SALES AB DE LA BASE A CON UN ACIDO B SELECCIONADO DE ACIDO CLORHIDRICO, ACIDO BROMHIDRICO, ACIDO SULFURICO, ENTRE OTROS; ASI COMO TAMBIEN A LAS FORMAS CRISTALINAS. SON COMPUESTOS PEFERIDOS: HIDROCLORURO DE ESTER ETILICO DE ACIDO 4-[4-[(2R)-3-[4-AMINO-3- CLORO-5-(TRIFLUOROMETIL)FENIL]-1-OXO-2[[[4-(1,2,4,5-TETRAHIDRO-2-OXO-3H-1,3-BENZODIAZEPIN-3-IL)-1-PIPERIDINIL]CARBONIL]OXI]PROPIL]-1-PIPERAZINIL]-PIPERIDIN-1-ACETICO, DIFUMARATO DE ESTER ETILICO DEL ACIDO 4-[4-(2R)-3-[4-AMINO-3-CLORO-5-(TRIFLUOROMETIL)FENIL]-1-OXO-2[[[4-(1,2,4,5-TETRAHIDRO-2-OXO-3H-1,3-BENZODIAZEPIN-3-IL)-1-PIPERIDINIL]CARBONIL]OXI]PROPIL]-1-PIPERAZINIL]-PIPERIDIN-1-ACETICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN METODO DE PREPARACION PARA UNA COMPOSICION FARMACEUTICA. DICHAS SALES TIENEN ACTIVIDAD ANTAGONISTA DE CGRP (PEPTIDO RELACIONADO CON EL GEN DE LA CALCITOCINA), SIENDO DE UTILIDAD PARA EL TRATAMIENTO DE DOLORES DE CABEZA Y ESPECIANMENTE MIGRANAS
PE2008001691A 2007-09-28 2008-09-26 Sales del acido 4-[4-[(2r)-3-[4-amino-3- cloro-5-(trifluorometil)fenil]-1-oxo-2[[[4-(1,2,4,5-tetrahidro-2-oxo-3h-1,3-benzodiazepin-3-il)-1-piperidinil]carbonil]oxi]propil]-1-piperazinil]-piperidin-1-acetico como antagonista de cgrp (peptido relaciona PE20091206A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007046888 2007-09-28

Publications (1)

Publication Number Publication Date
PE20091206A1 true PE20091206A1 (es) 2009-09-14

Family

ID=40032737

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001691A PE20091206A1 (es) 2007-09-28 2008-09-26 Sales del acido 4-[4-[(2r)-3-[4-amino-3- cloro-5-(trifluorometil)fenil]-1-oxo-2[[[4-(1,2,4,5-tetrahidro-2-oxo-3h-1,3-benzodiazepin-3-il)-1-piperidinil]carbonil]oxi]propil]-1-piperazinil]-piperidin-1-acetico como antagonista de cgrp (peptido relaciona

Country Status (16)

Country Link
US (1) US8551987B2 (es)
EP (1) EP2205587A2 (es)
JP (1) JP2010540494A (es)
KR (1) KR20100058598A (es)
CN (1) CN101809015A (es)
AR (1) AR068570A1 (es)
AU (1) AU2008306968A1 (es)
BR (1) BRPI0817585A2 (es)
CA (1) CA2700928A1 (es)
CL (1) CL2008002897A1 (es)
IL (1) IL204705A0 (es)
MX (1) MX2010003281A (es)
PE (1) PE20091206A1 (es)
TW (1) TW200922599A (es)
UY (1) UY31365A1 (es)
WO (1) WO2009043797A2 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005038831A1 (de) 2005-08-17 2007-02-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
WO2009043797A3 (de) 2009-07-02
UY31365A1 (es) 2009-04-30
JP2010540494A (ja) 2010-12-24
EP2205587A2 (de) 2010-07-14
TW200922599A (en) 2009-06-01
CA2700928A1 (en) 2009-04-09
AR068570A1 (es) 2009-11-18
IL204705A0 (en) 2010-11-30
US20120058994A1 (en) 2012-03-08
BRPI0817585A2 (pt) 2015-03-31
WO2009043797A2 (de) 2009-04-09
CN101809015A (zh) 2010-08-18
CL2008002897A1 (es) 2010-03-05
AU2008306968A1 (en) 2009-04-09
KR20100058598A (ko) 2010-06-03
US8551987B2 (en) 2013-10-08
MX2010003281A (es) 2010-04-09

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