PE20091167A1 - Derivados heterociclicos con actividad sobre los receptores de ampa - Google Patents
Derivados heterociclicos con actividad sobre los receptores de ampaInfo
- Publication number
- PE20091167A1 PE20091167A1 PE2008001915A PE2008001915A PE20091167A1 PE 20091167 A1 PE20091167 A1 PE 20091167A1 PE 2008001915 A PE2008001915 A PE 2008001915A PE 2008001915 A PE2008001915 A PE 2008001915A PE 20091167 A1 PE20091167 A1 PE 20091167A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- cycloalkyl
- activity
- pyrimidin
- Prior art date
Links
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 5
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-HYDROXYETHYL Chemical class 0.000 abstract 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 208000020358 Learning disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 201000003723 learning disability Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
REFERIDA A UN DERIVADO HETEROCICLICO DE FORMULA (I), DONDE L ES (CH2)m; R1 ES ALQUILO C1-C4, CICLOALQUILO C3-C5, ALQUILOXI C1-C4, HALOGENO, CN, ENTRE OTROS; R2 ES ALQUILO C1-C4, CICLOALQUILO C3-C5, ALQUILOXI C1-C4, ENTRE OTROS; X1, X2 Y X3 SON N O CR3; R3 ES H O METILO; Y1 ES NR4 O CHR4; R4 ES H O ALQUILO C1-C4; Y2 ES N O CR5; R5 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C8, ARILO C6-C10; m ES 1 O 2; R6 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C5; Y3 ES O,S, NR7; R7 ES H O ALQUILO C1-C4; Y4 ES N O CR8; R8 ES H O ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: 6-METIL-2-((4-(TIAZOL-2-ILMETILAMINO)METIL)-3-(TRIFLUOROMETIL)-1H-PIRAZOL-1-IL)METIL)TIENO[2,3-d]PIRIMIDIN-4(3H)-ONA, 2-((4-(2-HIDROXIPROPAN-2-IL)-3-(TRIFLUOROMETIL)-1H-PIRAZOL-1-IL)METIL)-6-METILTIENOL[2,3-d]PIRIMIDIN-4(3H)-ONA, 2-((4-(2-HIDROXIETIL)-3-(TRIFLUOROMETIL)-1H-PIRAZOL-1-IL)METIL)-6-METILTIENO[2,3-d]PIRIMIDIN-4(3H)-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LOS RECEPTORES DE AMPA (ACIDO ALFA-AMINO-3-HIDROXI-5-METIL-4-ISOXAZOL-PROPIONICO) Y SON UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, DEPRESION, TRANSTORNOS DEL APRENDIZAJE, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07120603 | 2007-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091167A1 true PE20091167A1 (es) | 2009-08-03 |
Family
ID=39472607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001915A PE20091167A1 (es) | 2007-11-13 | 2008-11-12 | Derivados heterociclicos con actividad sobre los receptores de ampa |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8129397B2 (es) |
| EP (1) | EP2209791B1 (es) |
| JP (1) | JP5455130B2 (es) |
| KR (1) | KR20100106370A (es) |
| CN (1) | CN101855227B (es) |
| AR (1) | AR069286A1 (es) |
| AU (1) | AU2008322986B2 (es) |
| BR (1) | BRPI0819202A2 (es) |
| CA (1) | CA2703901C (es) |
| CL (1) | CL2008003362A1 (es) |
| CO (1) | CO6270365A2 (es) |
| EC (1) | ECSP10010247A (es) |
| MX (1) | MX2010004686A (es) |
| PE (1) | PE20091167A1 (es) |
| RU (1) | RU2010123895A (es) |
| TW (1) | TW200934497A (es) |
| WO (1) | WO2009062930A1 (es) |
| ZA (1) | ZA201002580B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200934497A (en) | 2007-11-13 | 2009-08-16 | Organon Nv | Heterocyclic derivatives |
| WO2016081649A1 (en) * | 2014-11-18 | 2016-05-26 | Emory University | Thieno[2,3-d]pyrimidin-4-one derivatives as nmdar modulators and uses related thereto |
| US10500205B2 (en) | 2015-12-09 | 2019-12-10 | Cadent Therapeutics, Inc. | Thienopyrimidinone NMDA receptor modulators and uses thereof |
| RS60834B1 (sr) | 2015-12-09 | 2020-10-30 | Cadent Therapeutics Inc | Modulatori heteroaromatskog nmda receptora i njihove upotrebe |
| AU2017382339B2 (en) | 2016-12-22 | 2024-02-15 | Novartis Ag | NMDA receptor modulators and uses thereof |
| GB201702221D0 (en) * | 2017-02-10 | 2017-03-29 | Univ Of Sussex | Compounds |
| GB201803340D0 (en) | 2018-03-01 | 2018-04-18 | Univ Of Sussex | Compounds |
| CR20210125A (es) | 2018-08-03 | 2021-06-30 | Cadent Therapeutics Inc | Moduladores del receptor nmda heteroaromático y usos de los mismos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2324044T3 (es) * | 2003-10-08 | 2009-07-29 | Eli Lilly And Company | Derivados de pirrol y pirazol como potenciadores de los receptores de glutamato. |
| ATE552251T1 (de) * | 2004-01-09 | 2012-04-15 | Lilly Co Eli | Thiophen- und furanverbindungen |
| RU2401258C2 (ru) * | 2005-03-16 | 2010-10-10 | Авентис Фармасьютикалз Инк. | Дипиразолы в качестве средств для центральной нервной системы |
| GB0507298D0 (en) * | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US8293754B2 (en) * | 2005-06-14 | 2012-10-23 | Aska Pharmaceutical Co., Ltd. | Thienopyrimidine derivatives |
| TW200934497A (en) | 2007-11-13 | 2009-08-16 | Organon Nv | Heterocyclic derivatives |
-
2008
- 2008-10-28 TW TW097141383A patent/TW200934497A/zh unknown
- 2008-11-11 CN CN2008801156861A patent/CN101855227B/zh active Active
- 2008-11-11 EP EP08849917.3A patent/EP2209791B1/en active Active
- 2008-11-11 KR KR1020107012728A patent/KR20100106370A/ko not_active Withdrawn
- 2008-11-11 CA CA2703901A patent/CA2703901C/en active Active
- 2008-11-11 MX MX2010004686A patent/MX2010004686A/es not_active Application Discontinuation
- 2008-11-11 WO PCT/EP2008/065306 patent/WO2009062930A1/en not_active Ceased
- 2008-11-11 BR BRPI0819202 patent/BRPI0819202A2/pt not_active IP Right Cessation
- 2008-11-11 AU AU2008322986A patent/AU2008322986B2/en active Active
- 2008-11-11 JP JP2010533556A patent/JP5455130B2/ja active Active
- 2008-11-11 RU RU2010123895/04A patent/RU2010123895A/ru unknown
- 2008-11-12 US US12/269,306 patent/US8129397B2/en active Active
- 2008-11-12 CL CL2008003362A patent/CL2008003362A1/es unknown
- 2008-11-12 AR ARP080104926A patent/AR069286A1/es unknown
- 2008-11-12 PE PE2008001915A patent/PE20091167A1/es not_active Application Discontinuation
-
2010
- 2010-04-13 ZA ZA2010/02580A patent/ZA201002580B/en unknown
- 2010-05-13 CO CO10057470A patent/CO6270365A2/es not_active Application Discontinuation
- 2010-06-11 EC EC2010010247A patent/ECSP10010247A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8129397B2 (en) | 2012-03-06 |
| WO2009062930A1 (en) | 2009-05-22 |
| CA2703901A1 (en) | 2009-05-22 |
| CN101855227B (zh) | 2013-01-23 |
| JP5455130B2 (ja) | 2014-03-26 |
| JP2011503139A (ja) | 2011-01-27 |
| KR20100106370A (ko) | 2010-10-01 |
| MX2010004686A (es) | 2010-05-19 |
| AU2008322986B2 (en) | 2013-08-01 |
| EP2209791A1 (en) | 2010-07-28 |
| US20090131455A1 (en) | 2009-05-21 |
| CN101855227A (zh) | 2010-10-06 |
| AU2008322986A1 (en) | 2009-05-22 |
| AR069286A1 (es) | 2010-01-13 |
| BRPI0819202A2 (pt) | 2015-05-05 |
| CL2008003362A1 (es) | 2009-06-26 |
| RU2010123895A (ru) | 2011-12-20 |
| CA2703901C (en) | 2016-05-10 |
| ECSP10010247A (es) | 2010-07-30 |
| TW200934497A (en) | 2009-08-16 |
| CO6270365A2 (es) | 2011-04-20 |
| ZA201002580B (en) | 2010-12-29 |
| EP2209791B1 (en) | 2014-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |