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PE20091752A1 - Derivados de sulfonamida sustituida con actividad sobre los receptores de bradiquinina 1 - Google Patents

Derivados de sulfonamida sustituida con actividad sobre los receptores de bradiquinina 1

Info

Publication number
PE20091752A1
PE20091752A1 PE2009000497A PE2009000497A PE20091752A1 PE 20091752 A1 PE20091752 A1 PE 20091752A1 PE 2009000497 A PE2009000497 A PE 2009000497A PE 2009000497 A PE2009000497 A PE 2009000497A PE 20091752 A1 PE20091752 A1 PE 20091752A1
Authority
PE
Peru
Prior art keywords
pyridin
aryl
alkyl
bradiquinin
receptors
Prior art date
Application number
PE2009000497A
Other languages
English (en)
Inventor
Melanie Tracey Reich
Ellen Klegraf
Stefan Oberborsch
Stefan Schunk
Ruth Jostock
Sabine Maria Hees
Tieno Heiner Germann
Michael Franz Martin Engels
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20091752A1 publication Critical patent/PE20091752A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

REFERIDA A UN DERIVADO DE SULFONAMIDA DE FORMULA (I), DONDE Q ES UN ENLACE SIMPLE, -CH2- O -O-; X ES N, NR5, O, S O CR8; Y ES N, NR6, O, S O CR9; Z ES N, NR7, O, S O CR10; R5, R6 Y R7 SON H, ALQUILO C1.C6, ARILO O HETEROARILO; R1 ES CH(ARILO)2, ARILO, HETEROARILO, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, ARILO, ENTRE OTROS; R4 Y R4a SON H, CICLOALQUILO C3-C8, ALQUILO C1-C6, ENTRE OTROS; R8, R9 Y R10 SON H, CF3, CICLOALQUILO C3-C8, ENTRE OTROS; m, n Y p SON 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 3-(1-(4-METOXI-2,6-DIMETILSULFONIL)PIPERIDIN-2-IL)-1-(3-(PIRIDIN-4-IL)-6,7-DIHIDROISOXAZOLO[4,5-c]PIRIDIN-5(4H)-IL)PROPAN-1-ONA, 2-((1-(4-METOXI-2,6-DIMETILSULFONIL)PIPERIDIN-2-IL)METOXI)-1-(3-(PIRIDIN-4-IL)-6,7-DIHIDROISOXAZOLO[4,5-c]PIRIDIN-5(4H)-IL)ETANONA, 3-(1-(4-CLORO-2,5-DIMETILSULFONIL)PIPERIDIN-2-IL)-1-(3-(PIPERIDINA-1-CARBONIL)-6,7-DIHIDROISOXAZOLO[4,5-c]PIRIDIN-5(4H)-IL)PROPAN-1-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LOS RECEPTORES DE BRADIQUININA 1 (B1R) Y SON UTILES EN EL TRATAMIENTO DEL DOLOR, ENFERMEDADES DEL TRACTO RESPIRATORIO, ENFERMEDADES REUMATICAS, ENTRE OTRAS
PE2009000497A 2008-04-09 2009-04-08 Derivados de sulfonamida sustituida con actividad sobre los receptores de bradiquinina 1 PE20091752A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08007026 2008-04-09

Publications (1)

Publication Number Publication Date
PE20091752A1 true PE20091752A1 (es) 2009-12-10

Family

ID=39673532

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000497A PE20091752A1 (es) 2008-04-09 2009-04-08 Derivados de sulfonamida sustituida con actividad sobre los receptores de bradiquinina 1

Country Status (9)

Country Link
US (1) US8268814B2 (es)
EP (1) EP2260043A1 (es)
JP (1) JP2011516515A (es)
AR (1) AR071364A1 (es)
CA (1) CA2720879A1 (es)
CL (1) CL2009000878A1 (es)
PE (1) PE20091752A1 (es)
TW (1) TW200944530A (es)
WO (1) WO2009124746A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101553481A (zh) * 2006-09-29 2009-10-07 格吕伦塔尔有限公司 取代的磺酰胺衍生物
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9242994B2 (en) 2012-03-23 2016-01-26 Memorial Sloan-Kettering Cancer Center Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines
WO2020198583A1 (en) 2019-03-27 2020-10-01 Insilico Medicine Ip Limited Bicyclic jak inhibitors and uses thereof
EP4010333A1 (en) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051128A1 (en) * 2000-01-12 2001-07-19 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2007140383A2 (en) 2006-05-30 2007-12-06 Neurogen Corporation Spirocyclic sulfonamides and related compounds
EP2229394A1 (en) * 2008-01-17 2010-09-22 Grünenthal GmbH Substituted sulfonamide derivatives
WO2009090054A1 (en) * 2008-01-17 2009-07-23 Grünenthal GmbH Substituted sulfonamide derivatives

Also Published As

Publication number Publication date
JP2011516515A (ja) 2011-05-26
AR071364A1 (es) 2010-06-16
US8268814B2 (en) 2012-09-18
CA2720879A1 (en) 2009-10-15
CL2009000878A1 (es) 2009-08-07
TW200944530A (en) 2009-11-01
US20090275558A1 (en) 2009-11-05
EP2260043A1 (en) 2010-12-15
WO2009124746A1 (en) 2009-10-15

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