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PE20091586A1 - Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato - Google Patents

Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato

Info

Publication number
PE20091586A1
PE20091586A1 PE2009000511A PE2009000511A PE20091586A1 PE 20091586 A1 PE20091586 A1 PE 20091586A1 PE 2009000511 A PE2009000511 A PE 2009000511A PE 2009000511 A PE2009000511 A PE 2009000511A PE 20091586 A1 PE20091586 A1 PE 20091586A1
Authority
PE
Peru
Prior art keywords
amino
carboxamide
chloro
methylpyridine
phenoxy
Prior art date
Application number
PE2009000511A
Other languages
English (en)
Inventor
Michael Logers
Reinhold Gehring
Oliver Kuhn
Mike Matthaus
Klaus-Helmut Mohrs
Matthias Muller-Gliemann
Jurgen Stiehl
Mathias Berwe
Jana Lenz
Werner Heilmann
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091586(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20091586A1 publication Critical patent/PE20091586A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR 4-{4-[({[4-CLORO-3-(TRIFLUOROMETIL)FENIL]AMINO}CARBONIL)AMINO]FENOXI}-N-METILPIRIDINA-2-CARBOXAMIDA Y SU SAL TOSILATO QUE COMPRENDE: A) REACCIONAR 4-CLORO-N-METILPIRIDIN-2-CARBOXAMIDA CON 4-AMINOFENOL RESULTANDO 4-(4-AMINOFENOXI)-N-METILPIRIDINA-2-CARBOXAMIDA; B) REACCIONAR COMPUESTO RESULTANTE CON ISOCIANATO DE 4-CLORO-3-TRIFLUOROMETILFENILO RESULTANDO EL COMPUESTO 4-{4-[({[4-CLORO-3-(TRIFLUOROMETIL)FENIL]AMINO}CARBONIL)AMINO]FENOXI}-N-METILPIRIDINA-2-CARBOXAMIDA D) REACCIONAR COMPUESTO CON ACIDO p-TOLUENOSULFONICO. DICHO COMPUESTO ES INHIBIDOR DE ENZIMA Raf QUINASA SIENDO UTIL EN EL TRATAMIENTO DE TRANSTORNOS ANGIOGENICOS COMO EL CANCER
PE2009000511A 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato PE20091586A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04023131 2004-09-29

Publications (1)

Publication Number Publication Date
PE20091586A1 true PE20091586A1 (es) 2009-10-31

Family

ID=35457568

Family Applications (5)

Application Number Title Priority Date Filing Date
PE2009000510A PE20091585A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato
PE2009000509A PE20091584A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato
PE2005001144A PE20060825A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato
PE2009000512A PE20091587A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-cloro-n-metilpiridin-2-carboxamida
PE2009000511A PE20091586A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato

Family Applications Before (4)

Application Number Title Priority Date Filing Date
PE2009000510A PE20091585A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato
PE2009000509A PE20091584A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato
PE2005001144A PE20060825A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato
PE2009000512A PE20091587A1 (es) 2004-09-29 2005-09-28 Procedimiento para preparar 4-cloro-n-metilpiridin-2-carboxamida

Country Status (34)

Country Link
US (1) US8124782B2 (es)
EP (1) EP1797037B1 (es)
JP (2) JP2008514657A (es)
KR (1) KR101263032B1 (es)
CN (1) CN101052619B (es)
AR (1) AR053973A1 (es)
AU (1) AU2005289099B2 (es)
BR (1) BRPI0515944B1 (es)
CA (1) CA2581835C (es)
CU (1) CU23754B7 (es)
CY (1) CY1116126T1 (es)
DK (1) DK1797037T3 (es)
DO (1) DOP2005000183A (es)
EC (1) ECSP077357A (es)
ES (1) ES2532377T3 (es)
GT (1) GT200500269A (es)
HN (1) HN2005000768A (es)
HR (1) HRP20150295T1 (es)
IL (1) IL182046A0 (es)
MA (1) MA28883B1 (es)
MY (1) MY149873A (es)
NO (1) NO339647B1 (es)
NZ (1) NZ554119A (es)
PE (5) PE20091585A1 (es)
PL (1) PL1797037T3 (es)
PT (1) PT1797037E (es)
SG (1) SG155997A1 (es)
SI (1) SI1797037T1 (es)
SV (1) SV2006002243A (es)
TW (1) TWI382973B (es)
UA (1) UA90691C2 (es)
UY (1) UY29143A1 (es)
WO (1) WO2006034796A1 (es)
ZA (1) ZA200702511B (es)

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CN104761492A (zh) * 2014-01-03 2015-07-08 正大天晴药业集团股份有限公司 对甲苯磺酸索拉非尼的晶型及其制备方法
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CN110204483B (zh) * 2014-12-01 2021-06-29 石药集团中奇制药技术（石家庄）有限公司 一种甲苯磺酸索拉非尼新晶型及其制备方法
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CN105181844A (zh) * 2015-09-11 2015-12-23 江苏嘉逸医药有限公司 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法
CN105585523A (zh) * 2015-12-29 2016-05-18 上海北卡医药技术有限公司 一种对甲苯磺酸索拉非尼的新晶型及其制备方法和用途
CN107840823B (zh) * 2016-09-20 2021-08-17 意大利合成制造有限公司 用于制备甲苯磺酸索拉非尼乙醇溶剂化物和iii型甲苯磺酸索拉非尼的可变规模的方法
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Also Published As

Publication number Publication date
PT1797037E (pt) 2015-03-17
HRP20150295T1 (hr) 2015-05-22
UA90691C2 (en) 2010-05-25
ZA200702511B (en) 2008-07-30
TWI382973B (zh) 2013-01-21
IL182046A0 (en) 2007-07-24
KR20070058676A (ko) 2007-06-08
DOP2005000183A (es) 2006-03-31
NO20072173L (no) 2007-06-14
MA28883B1 (fr) 2007-09-03
SV2006002243A (es) 2006-10-13
BRPI0515944A (pt) 2008-08-12
CN101052619A (zh) 2007-10-10
PE20091585A1 (es) 2009-10-31
ECSP077357A (es) 2007-04-26
BRPI0515944B1 (pt) 2021-11-09
UY29143A1 (es) 2006-04-28
US20080262236A1 (en) 2008-10-23
AU2005289099B2 (en) 2012-07-19
GT200500269A (es) 2006-05-11
EP1797037B1 (en) 2014-12-17
AU2005289099A1 (en) 2006-04-06
KR101263032B1 (ko) 2013-05-09
TW200626551A (en) 2006-08-01
ES2532377T3 (es) 2015-03-26
PE20091587A1 (es) 2009-11-05
CY1116126T1 (el) 2017-02-08
EP1797037A1 (en) 2007-06-20
PE20060825A1 (es) 2006-10-20
HN2005000768A (es) 2010-09-17
PE20091584A1 (es) 2009-10-28
JP2013067625A (ja) 2013-04-18
NZ554119A (en) 2010-07-30
HK1113484A1 (en) 2008-10-03
WO2006034796A1 (en) 2006-04-06
SG155997A1 (en) 2009-10-29
JP2008514657A (ja) 2008-05-08
DK1797037T3 (en) 2015-03-30
JP5583190B2 (ja) 2014-09-03
MY149873A (en) 2013-10-31
US8124782B2 (en) 2012-02-28
CU20070069A7 (es) 2010-11-27
CU23754B7 (es) 2012-01-31
AR053973A1 (es) 2007-05-30
PL1797037T3 (pl) 2015-07-31
CA2581835A1 (en) 2006-04-06
CN101052619B (zh) 2012-02-22
SI1797037T1 (sl) 2015-06-30
NO339647B1 (no) 2017-01-16
CA2581835C (en) 2012-12-18

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