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PE20091489A1 - HEPATITIS C VIRUS INHIBITORS - Google Patents

HEPATITIS C VIRUS INHIBITORS

Info

Publication number
PE20091489A1
PE20091489A1 PE2008000313A PE2008000313A PE20091489A1 PE 20091489 A1 PE20091489 A1 PE 20091489A1 PE 2008000313 A PE2008000313 A PE 2008000313A PE 2008000313 A PE2008000313 A PE 2008000313A PE 20091489 A1 PE20091489 A1 PE 20091489A1
Authority
PE
Peru
Prior art keywords
imidazol
azabicyclo
hex
hcv
hepatitis
Prior art date
Application number
PE2008000313A
Other languages
Spanish (es)
Inventor
Carol Bachand
Makonen Belema
Daniel H Deon
Jason Goodrich
Clint A James
Rico Lavoie
Omar D Lopez
Alain Martel
Nicholas A Meanwell
Van N Nguyen
Jeffrey Lee Romine
Edward H Ruediger
Lawrence B Snyder
Laurent Denis R St
Fukang Yang
David R Langley
Gan Wang
Lawrence G Hamann
Andrew C Good
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to PE2008000313A priority Critical patent/PE20091489A1/en
Publication of PE20091489A1 publication Critical patent/PE20091489A1/en

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  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZOLIL BIFENIL IMIDAZOLES TALES COMO: ((1S)-2-((1R,3S,5R)-3-(4-(4'-(2-((1R,3S,5R)-2-(N-(METOXICARBONIL)-L-ALANIL)-2-AZABICICLO[3.1.0]HEX-3-IL)-1H-IMIDAZOL-4-IL)-4-BIFENILIL)-1H-IMIDAZOL-2-IL)-2-AZABICICLO[3.1.0]HEX-2-IL)-1-METIL-2-OXOETIL)CARBAMATO DE METILO, (4,4'-BIFENILDIILBIS(1H-IMIDAZOL-4,2-DIIL(1R,3S,5R)-2-AZABICICLO[3.1.0]HEXANO-3,2-DIIL((2S)-1-OXO-1,2-BUTANODIIL)))BISCARBAMATO DE DIMETILO, (2-((1R,3S,5R)-3-(4-(4'-(2-((1R,3S,5R)-2-(((METOXICARBONIL)AMINO)ACETIL)-2-AZABICICLO[3.1.0]HEX-3-IL)-1H-IMIDAZOL-4-IL)-4-BIFENILIL)-1H-IMIDAZOL-2-IL)-2-AZABICICLO[3.1.0]HEX-2-IL)-2-OXOETIL)CARBAMATO DE METILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE UNO O MAS COMPUESTOS ADICIONALES CON ACTIVIDAD ANTI-VHC TALES COMO RIBAVIRINA, INTERFERON ALFA 2B, INTERFERON ALFA PEGILADO, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA FUNCION DE LA PROTEINA NS5A CODIFICADA POR EL VIRUS DE LA HEPATITIS C (VHC) SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES PRODUCIDAS POR EL VHCREFERS TO COMPOUNDS DERIVED FROM IMIDAZOLYL BIPHENYL IMIDAZOLES SUCH AS: ((1S) -2 - ((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - (N- (METOXYCARBONYL) -L-ALANIL) -2-AZABICYCLO [3.1.0] HEX-3-IL) -1H-IMIDAZOL-4-IL) -4-BIPHENYLIL) -1H-IMIDAZOL-2-IL) -2-AZABICYCLE [3.1.0] HEX-2-IL) -1-METHYL-2-OXOETHYL) METHYL CARBAMATE, (4,4'-BIPHENYLDIYLBIS (1H-IMIDAZOL-4,2-DIIL (1R, 3S, 5R) -2-AZABICYCLO [3.1.0] HEXANE-3,2-DIYL ((2S) -1-OXO-1,2-BUTANODIYL))) DIMETHYL BISCARBAMATE, (2 - ((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - (((METHOXICARBONYL) AMINO) ACETYL) -2-AZABICYCLO [3.1.0] HEX-3-IL) -1H -IMIDAZOL-4-IL) -4-BIPHENYLIL) -1H-IMIDAZOL-2-IL) -2-AZABICYCLO [3.1.0] HEX-2-IL) -2-OXOETHYL) METHYL CARBAMATE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION CONTAINING ONE OR MORE ADDITIONAL COMPOUNDS WITH ANTI-HCV ACTIVITY SUCH AS RIBAVIRIN, INTERFERED ALPHA 2B, INTERFERED ALPHA STICKED, AMONG OTHERS. SUCH COMPOUNDS ARE INHIBITORS OF THE FUNCTION OF THE PROTEIN NS5A CODED BY THE VIRUS OF HEPATITIS C (HCV) AND ARE USEFUL IN THE TREATMENT OF INFECTIONS PRODUCED BY HCV

PE2008000313A 2008-02-13 2008-02-13 HEPATITIS C VIRUS INHIBITORS PE20091489A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PE2008000313A PE20091489A1 (en) 2008-02-13 2008-02-13 HEPATITIS C VIRUS INHIBITORS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PE2008000313A PE20091489A1 (en) 2008-02-13 2008-02-13 HEPATITIS C VIRUS INHIBITORS

Publications (1)

Publication Number Publication Date
PE20091489A1 true PE20091489A1 (en) 2009-09-25

Family

ID=41665391

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000313A PE20091489A1 (en) 2008-02-13 2008-02-13 HEPATITIS C VIRUS INHIBITORS

Country Status (1)

Country Link
PE (1) PE20091489A1 (en)

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed