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PE20090048A1 - Derivados de glicina n-sustituidos: inhibidores de prolil hidroxilasa - Google Patents

Derivados de glicina n-sustituidos: inhibidores de prolil hidroxilasa

Info

Publication number
PE20090048A1
PE20090048A1 PE2008000123A PE2008000123A PE20090048A1 PE 20090048 A1 PE20090048 A1 PE 20090048A1 PE 2008000123 A PE2008000123 A PE 2008000123A PE 2008000123 A PE2008000123 A PE 2008000123A PE 20090048 A1 PE20090048 A1 PE 20090048A1
Authority
PE
Peru
Prior art keywords
alkyl
glycine derivatives
prolyl hydroxylase
glycine
hydroxylase inhibitors
Prior art date
Application number
PE2008000123A
Other languages
English (en)
Inventor
Kevin J Duffy
Antony N Shaw
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39618260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090048(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20090048A1 publication Critical patent/PE20090048A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE GLICINA HETEROAROMATICOS N-SUSTITUIDOS DE FORMULA (I), EN DONDE R1 ES H, -NR5R6, ALQUILO(C1-C10), ALQUENILO(C2-C10), ENTRE OTROS; R2 ES -NR7R8 O -OR9; R3 ES H O ALQUILO(C1-C4); R4 ES H, -NR5R6, ALQUILO(C1-C10), ALQUENILO(C2-C10), ENTRE OTROS; CADA R5 Y R6 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C10), CICLOALQUILO(C3-C10), ENTRE OTROS. SON SELECCIONADOS: N-{[4-HIDROXI-6-OXO-2-FENIL-1-(FENILMETIL)-1,6-DIHIDRO-5-PIRIMIDINIL]CARBONIL}GLICINA, N-{[4-HIDROXI-2-[4-(METILOXI)FENIL]-6-OXO-1-(FENILMETIL)-1,6-DIHIDRO-5-PIRIMIDINIL] CARBONIL}GLICINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON ANTAGONISTAS DE HIF PROLIL HIDROXILASAS POR LO QUE SON UTILES EN EL TRATAMIENTO DE LA ANEMIA, ISQUEMIA, APOPLEJIA Y CITOPROTECCION
PE2008000123A 2007-01-12 2008-01-11 Derivados de glicina n-sustituidos: inhibidores de prolil hidroxilasa PE20090048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88470607P 2007-01-12 2007-01-12

Publications (1)

Publication Number Publication Date
PE20090048A1 true PE20090048A1 (es) 2009-03-28

Family

ID=39618260

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000123A PE20090048A1 (es) 2007-01-12 2008-01-11 Derivados de glicina n-sustituidos: inhibidores de prolil hidroxilasa

Country Status (6)

Country Link
US (1) US20080171756A1 (es)
AR (1) AR064877A1 (es)
CL (1) CL2008000065A1 (es)
PE (1) PE20090048A1 (es)
TW (1) TW200845994A (es)
WO (1) WO2008089051A1 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
TWI394747B (zh) 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
PT3357911T (pt) 2006-06-26 2022-07-11 Akebia Therapeutics Inc Inibidores da prolil-hidroxilase e métodos de utilização
US8048892B2 (en) 2006-12-18 2011-11-01 Amgen Inc. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
WO2008076427A2 (en) * 2006-12-18 2008-06-26 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US7569726B2 (en) * 2007-04-18 2009-08-04 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
ES2442847T3 (es) * 2007-04-18 2014-02-13 Amgen, Inc Quinolonas y azaquinolonas que inhiben la prolil hidroxilasa
AU2008248165B2 (en) * 2007-05-04 2011-12-08 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
EP2150251B9 (en) * 2007-05-04 2013-02-27 Amgen, Inc Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity
EP2252619B1 (en) 2008-01-11 2013-10-09 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity
WO2009100250A1 (en) 2008-02-05 2009-08-13 Fibrogen, Inc. Chromene derivatives and use thereof as hif hydroxylase activity inhibitors
SI2294066T1 (sl) 2008-04-28 2014-12-31 Janssen Pharmaceutica N.V. Benzoimidazoli kot inhibitorji prolil-hidroksilaze
CN102264740B (zh) 2008-08-20 2014-10-15 菲布罗根有限公司 一种吡咯[1,2-b]哒嗪衍生物及其作为hif调节剂的用途
EP2326178A4 (en) * 2008-08-21 2012-10-24 Glaxosmithkline Llc INHIBITORS OF PROLYL-HYDROXYLASE
US20110144167A1 (en) * 2008-08-25 2011-06-16 Smithkline Beecham Corporation Prolyl Hydroxylase Inhibitors
AU2009314155B2 (en) 2008-11-14 2015-10-08 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
EP2399910B1 (en) 2009-02-13 2014-04-02 Shionogi&Co., Ltd. Triazine derivatives as p2x3 and/or p2x2/3 receptor antagonists and pharmaceutical composition containing them
AU2010266559A1 (en) * 2009-06-30 2011-12-15 Merck Sharp & Dohme Corp. Substituted 4-hydroxypyrimidine-5-carboxamides
US8815865B2 (en) 2009-06-30 2014-08-26 Merck Sharp & Dohme Corp. Substituted 4-hydroxypyrimidine-5-carboxamides
MY163022A (en) * 2009-10-21 2017-07-31 Daiichi Sankyo Co Ltd 5-hydroxypyrimidine-4-carboxamide derivative
BR112012010766A2 (pt) 2009-11-06 2015-10-06 Aerpio Therapeutics Inc composições e métodos de tratamento da colite e de outras doenças instestinais
EP2604260B1 (en) * 2010-08-10 2017-05-10 Shionogi&Co., Ltd. Novel heterocyclic derivatives and pharmaceutical composition containing same
JP5594706B2 (ja) 2010-08-10 2014-09-24 塩野義製薬株式会社 トリアジン誘導体およびそれを含有する鎮痛作用を有する医薬組成物
WO2012106472A1 (en) 2011-02-02 2012-08-09 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor (hif) hydroxylase
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
NO2686520T3 (es) 2011-06-06 2018-03-17
WO2012170442A1 (en) 2011-06-06 2012-12-13 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
AU2012328763A1 (en) 2011-10-25 2014-05-01 Janssen Pharmaceutica Nv Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo(d)imidazol-2-yl)-1H-pyrazole-4-carboxylic acid
JP6124351B2 (ja) 2012-02-09 2017-05-10 塩野義製薬株式会社 複素環および炭素環誘導体
RU2503665C1 (ru) * 2012-05-03 2014-01-10 Открытое акционерное общество "Государственный научно-исследовательский институт "Кристалл" (ОАО "ГосНИИ "Кристалл") Способ получения 2-метилпиримидин-4,6-(3н,5н)-диона
RU2503666C1 (ru) * 2012-06-25 2014-01-10 Открытое акционерное общество "Государственный научно-исследовательский институт "Кристалл" (ОАО "ГосНИИ "Кристалл") Способ получения 2-метилпиримидин-4,6-(3н, 5н)-диона
EP2881384B1 (en) 2012-07-30 2018-05-30 Taisho Pharmaceutical Co., Ltd. Partially saturated nitrogen-containing heterocyclic compound
EP3007695B1 (en) 2013-06-13 2024-02-07 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
CR20160222U (es) 2013-11-15 2016-08-26 Akebia Therapeutics Inc Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas
JP5975122B2 (ja) * 2014-01-29 2016-08-23 大正製薬株式会社 ［（４−ヒドロキシ−２−オキソ−１，２，５，６−テトラヒドロ−３−ピリジニル）カルボニル］グリシン化合物の結晶形及びそれらの製造方法
WO2016034108A1 (zh) 2014-09-02 2016-03-10 广东东阳光药业有限公司 喹啉酮类化合物及其应用
CA2974691A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
UA123308C2 (uk) 2015-04-01 2021-03-17 Екебіа Терапьютікс, Інк. Композиції і способи для лікування анемії
UY36949A (es) 2015-10-14 2017-04-28 Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware 2,4-dihidroxi-nicotinamidas como agonistas de apj
MX391259B (es) 2015-10-14 2025-03-21 X Therma Inc Composiciones y métodos para reducir la formación de cristales de hielo.
AU2017238504B2 (en) * 2016-03-24 2021-05-27 Bristol-Myers Squibb Company 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as APJ agonists
JP7440989B2 (ja) 2018-05-09 2024-02-29 アケビア セラピューティクス インコーポレイテッド ２－［５－（３－クロロフェニル）－３－ヒドロキシピリジン－２－カルボニル］アミノ］酢酸を調製するための方法
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
RU2738605C1 (ru) * 2020-03-06 2020-12-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) 5-Замещённые-6-гидрокси-2,3-дифенилпиримидин-4-(3Н)-оны и способ их получения
RU2738107C1 (ru) * 2020-03-06 2020-12-08 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) Способ получения 5-замещённых-6-гидрокси-2,3-дифенилпиримидин-4(3Н)-онов
RU2757391C1 (ru) * 2021-02-24 2021-10-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) 1,2-Дифенил-5-бутил-6-оксо-1,6-дигидропиримидин-4-олят натрия и способ его получения
CN118005535B (zh) * 2024-04-10 2024-12-27 天津市长芦化工新材料有限公司 全氟异丁腈的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912261A (en) * 1994-12-20 1999-06-15 Nippon Zoki Pharmaceutical Co., Ltd. Carboxyalkyl heterocyclic derivatives
CN102552261A (zh) * 2001-12-06 2012-07-11 法布罗根股份有限公司 提高内源性红细胞生成素(epo)的方法
WO2003106434A1 (ja) * 2002-06-14 2003-12-24 味の素株式会社 ピリミジン化合物の製造方法
US7183287B2 (en) * 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones

Also Published As

Publication number Publication date
TW200845994A (en) 2008-12-01
CL2008000065A1 (es) 2008-09-22
WO2008089051A1 (en) 2008-07-24
US20080171756A1 (en) 2008-07-17
AR064877A1 (es) 2009-04-29

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