PE20090978A1 - DERIVATIVES OF FURO {3,2-d} PYRIMIDINE - Google Patents
DERIVATIVES OF FURO {3,2-d} PYRIMIDINEInfo
- Publication number
- PE20090978A1 PE20090978A1 PE2008001844A PE2008001844A PE20090978A1 PE 20090978 A1 PE20090978 A1 PE 20090978A1 PE 2008001844 A PE2008001844 A PE 2008001844A PE 2008001844 A PE2008001844 A PE 2008001844A PE 20090978 A1 PE20090978 A1 PE 20090978A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrimidine
- methylamine
- furo
- compounds
- derivatives
- Prior art date
Links
- JUQAECQBUNODQP-UHFFFAOYSA-N furo[3,2-d]pyrimidine Chemical class C1=NC=C2OC=CC2=N1 JUQAECQBUNODQP-UHFFFAOYSA-N 0.000 title 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 FURO [3,2-d] PYRIMIDINE DERIVATIVE COMPOUNDS Chemical class 0.000 abstract 1
- 102000004187 Histamine H4 receptors Human genes 0.000 abstract 1
- 108090000796 Histamine H4 receptors Proteins 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS FURO[3,2-d]PIRIMIDINA DE FORMULA (I) DONDE R1 ES H, NH2; R2 Y R3 FORMAN JUNTO CON EL ATOMO DE N 3-(METILAMINO)AZETIDIN-1-IL, PIPERAZIN-1-IL, (1,4-DIAZEPAN-1-IL), ENTRE OTROS; R4 ES H, ALQUILO C1-C4, ENTRE OTROS, DONDE R4 PUEDE ESTAR SITUADO EN CUALQUIER POSICION DISPONIBLE DEL ANILLO A; n ES 0-3. SON COMPUESTOS SELECCIONADOS: 4-[(3R)-3-(METILAMINO)PIRROLIDIN-1-IL]-6,7,8,9-TETRAHIDROBENZOFURO[3,2-d]PIRIMIDIN-2-AMINA; 4-[3-(METILAMINO)AZETIDIN-1-IL]-6,7,8,9-TETRAHIDROBENZOFURO[3,2-d]PIRIMIDINA; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR H4 DE LA HISTAMINA, UTILES EN EL TRATAMIENTO DE ENFERMEDADES ALERGICAS, INMUNOLOGICAS E INFLAMATORIAS Y DOLORREFERRING TO FURO [3,2-d] PYRIMIDINE DERIVATIVE COMPOUNDS OF FORMULA (I) WHERE R1 IS H, NH2; R2 AND R3 FORM TOGETHER WITH THE ATOM OF N 3- (METHYLAMINE) AZETIDIN-1-IL, PIPERAZIN-1-IL, (1,4-DIAZEPAN-1-IL), AMONG OTHERS; R4 IS H, C1-C4 RENTAL, AMONG OTHERS, WHERE R4 MAY BE LOCATED IN ANY POSITION AVAILABLE FROM RING A; n IS 0-3. SELECTED COMPOUNDS ARE: 4 - [(3R) -3- (METHYLAMINE) PYRROLIDIN-1-IL] -6,7,8,9-TETRAHIDROBENZOFURO [3,2-d] PYRIMIDIN-2-AMINE; 4- [3- (METHYLAMINE) AZETHYDIN-1-IL] -6,7,8,9-TETRAHYDROBENZOFURO [3,2-d] PYRIMIDINE; AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS TO THE HISTAMINE H4 RECEPTOR, USEFUL IN THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND PAIN
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07381071 | 2007-10-30 | ||
| US1993708P | 2008-01-09 | 2008-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090978A1 true PE20090978A1 (en) | 2009-07-13 |
Family
ID=39217961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001844A PE20090978A1 (en) | 2007-10-30 | 2008-10-28 | DERIVATIVES OF FURO {3,2-d} PYRIMIDINE |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR069113A1 (en) |
| PE (1) | PE20090978A1 (en) |
| TW (1) | TW200934783A (en) |
| WO (1) | WO2009056551A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| JP6047563B2 (en) | 2011-07-08 | 2016-12-21 | ノバルティス アーゲー | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of diseases |
| SI2858647T1 (en) | 2012-06-08 | 2018-11-30 | Sensorion | H4 receptor inhibitors for treating tinnitus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005303893A1 (en) * | 2004-11-11 | 2006-05-18 | Argenta Discovery Ltd | Pyrimidine compounds as histamine modulators |
-
2008
- 2008-10-28 WO PCT/EP2008/064622 patent/WO2009056551A1/en not_active Ceased
- 2008-10-28 PE PE2008001844A patent/PE20090978A1/en not_active Application Discontinuation
- 2008-10-29 AR ARP080104742A patent/AR069113A1/en unknown
- 2008-10-29 TW TW097141596A patent/TW200934783A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR069113A1 (en) | 2009-12-30 |
| TW200934783A (en) | 2009-08-16 |
| WO2009056551A1 (en) | 2009-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |