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PE20090776A1 - DERIVADOS DE TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL COMO AGONISTAS DEL RECEPTOR DE GLUCOCORTICOSTEROIDES - Google Patents

DERIVADOS DE TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL COMO AGONISTAS DEL RECEPTOR DE GLUCOCORTICOSTEROIDES

Info

Publication number
PE20090776A1
PE20090776A1 PE2008001725A PE2008001725A PE20090776A1 PE 20090776 A1 PE20090776 A1 PE 20090776A1 PE 2008001725 A PE2008001725 A PE 2008001725A PE 2008001725 A PE2008001725 A PE 2008001725A PE 20090776 A1 PE20090776 A1 PE 20090776A1
Authority
PE
Peru
Prior art keywords
tetradecahydrocyclopenta
methyl
naftho
halogen
agonists
Prior art date
Application number
PE2008001725A
Other languages
English (en)
Inventor
Hakan Bladh
Frank Burkamp
Balint Gabos
Peter Hansen
Svetlana Ivanova
Carolina Lawitz
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40328402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090776(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090776A1 publication Critical patent/PE20090776A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL DE FORMULA (I) DONDE X1, X2 Y X3 SON CADA UNO CH O N; R1 ES HALOGENO, CH3 U OCH3; R2 ES HALOGENO, -C(O)OCH3, -C(O)-S-CH2CN, ENTRE OTROS; R3a ES H O METILO; R3b ES H O F; R4 ES -C(O)-S-C(O)N(CH3)2, -C(O)CH2Cl, -C(O)-Y-CH(R11)-R9, ENTRE OTROS, EN DONDE Y ES O, S O NH; R9 ES H, HALOGENO, CN, ENTRE OTROS; R11 ES H O METILO; R5 ES OH, -OCH2SCH3, ENTRE OTROS; n Y p SON CADA UNO 0 O 1; R6 ES H, HALOGENO O METILO. SON COMPUESTOS PREFERIDOS: 4-METIL-1,3-TIAZOL-5-CARBOXILATO DE (1R,3aS,3bS,10aR,10bS,11S,12aS)-1-{[(FLUOROMETIL)TIO]CARBONIL}-7-(4-FLUOROFENIL)-11-HIDROXI-10a,12a-DIMETIL-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL-1-ILO, 4-METIL-1,3-TIAZOL-5-CARBOXILATO DE (1R,3aS,3bS,10aR,10bS,11S,12aS)-1-{[(CIANOMETIL)TIO]CARBONIL}-7-(4-FLUOROFENIL)-11-HIDROXI-10a,12a-DIMETIL-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL-1-ILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE GLUCOCORTICOSTEROIDES (GC) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, RINITIS ALERGICA
PE2008001725A 2007-10-04 2008-10-03 DERIVADOS DE TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL COMO AGONISTAS DEL RECEPTOR DE GLUCOCORTICOSTEROIDES PE20090776A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97741607P 2007-10-04 2007-10-04

Publications (1)

Publication Number Publication Date
PE20090776A1 true PE20090776A1 (es) 2009-07-23

Family

ID=40328402

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001725A PE20090776A1 (es) 2007-10-04 2008-10-03 DERIVADOS DE TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL COMO AGONISTAS DEL RECEPTOR DE GLUCOCORTICOSTEROIDES

Country Status (23)

Country Link
US (2) US8163724B2 (es)
EP (1) EP2207788A1 (es)
JP (1) JP2010540612A (es)
KR (1) KR20100087147A (es)
CN (1) CN101883778A (es)
AR (1) AR068734A1 (es)
AU (1) AU2008306593C1 (es)
BR (1) BRPI0817941A2 (es)
CA (1) CA2700181A1 (es)
CL (1) CL2008002954A1 (es)
CO (1) CO6270214A2 (es)
CR (1) CR11345A (es)
DO (1) DOP2010000094A (es)
EA (1) EA201000436A1 (es)
IL (1) IL204611A0 (es)
MX (1) MX2010003698A (es)
NI (1) NI201000043A (es)
NZ (1) NZ584160A (es)
PE (1) PE20090776A1 (es)
TW (1) TW200918047A (es)
UY (1) UY31375A1 (es)
WO (1) WO2009044200A1 (es)
ZA (1) ZA201002223B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584160A (en) 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
CN101945885A (zh) * 2007-12-20 2011-01-12 阿斯利康(瑞典)有限公司 用作糖皮质激素受体激动剂的甾类衍生物
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
US20120171126A1 (en) 2009-06-16 2012-07-05 Purakkattle Biju J NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS COMPOSITIONS AND USES THEREOF
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
GB201016912D0 (en) * 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
WO2012094618A1 (en) * 2011-01-07 2012-07-12 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
PH12013501934A1 (en) 2011-03-18 2022-04-08 Bayer Ip Gmbh N-(3-carbamoylphenyl)-1h-pyrazole-5-carboxamide derivatives and the use thereof for controlling animal pests
US9526729B2 (en) * 2013-01-29 2016-12-27 Hsiao Lily Yu Medicament for treating peripheral neuropathies
ES2751457T3 (es) 2013-09-25 2020-03-31 Van Andel Res Institute Glucocorticoides altamente potentes
JP7146750B2 (ja) * 2016-10-14 2022-10-04 ヴァン アンデル リサーチ インスティテュート 非常に強力な糖質コルチコイドの構造およびデザインのための機構

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE585432A (fr) 1958-12-08 1960-06-08 American Cyanamid Co Stéroïdes fluorés.
NL100550C (es) 1959-02-16
US3129218A (en) 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2727367A1 (de) 1977-06-14 1979-01-04 Schering Ag Neue kortikoide
DE2735110A1 (de) 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
JPS6067495A (ja) 1983-09-22 1985-04-17 Ota Seiyaku Kk ピラゾール誘導体
SE8306370D0 (sv) 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
WO1994025478A1 (en) 1993-04-29 1994-11-10 Instytut Farmaceutyczny 16α,17α-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
KR100489174B1 (ko) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-아닐리노퀴나졸린유도체
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
BR0112224A (pt) 2000-07-07 2003-06-10 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
SK52003A3 (en) 2000-07-07 2003-07-01 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same
GB0110411D0 (en) 2001-04-27 2001-06-20 Astrazeneca Ab Chemical process
WO2002088167A1 (en) * 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
ITMI20022606A1 (it) 2002-12-09 2004-06-10 Farmabios Spa Processo di sintesi di steroidi polialogenati.
WO2005028495A1 (en) 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
WO2005063777A1 (en) 2003-12-23 2005-07-14 Corus Pharma Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
WO2007054974A2 (en) 2005-09-28 2007-05-18 Arch Pharmalab Limited A green chemistry process for the preparation of pregnadiene esters
NZ584160A (en) 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
CN101945885A (zh) 2007-12-20 2011-01-12 阿斯利康(瑞典)有限公司 用作糖皮质激素受体激动剂的甾类衍生物
WO2009108118A1 (en) 2008-02-27 2009-09-03 Astrazeneca Ab 16 alpha, 17 alpa-acetal glucocorticosteroidal derivatives and their use
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32525A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32523A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32521A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias

Also Published As

Publication number Publication date
KR20100087147A (ko) 2010-08-03
AU2008306593A1 (en) 2009-04-09
CO6270214A2 (es) 2011-04-20
US20120178726A1 (en) 2012-07-12
AU2008306593C1 (en) 2012-10-04
EA201000436A1 (ru) 2010-10-29
MX2010003698A (es) 2010-04-21
NZ584160A (en) 2011-05-27
EP2207788A1 (en) 2010-07-21
JP2010540612A (ja) 2010-12-24
CL2008002954A1 (es) 2010-01-15
TW200918047A (en) 2009-05-01
DOP2010000094A (es) 2012-08-15
BRPI0817941A2 (pt) 2015-05-05
NI201000043A (es) 2012-09-10
AU2008306593B2 (en) 2012-04-12
CR11345A (es) 2010-07-15
CN101883778A (zh) 2010-11-10
AR068734A1 (es) 2009-12-02
US8163724B2 (en) 2012-04-24
CA2700181A1 (en) 2009-04-09
IL204611A0 (en) 2010-11-30
WO2009044200A1 (en) 2009-04-09
UY31375A1 (es) 2009-05-29
ZA201002223B (en) 2010-12-29
US20090286835A1 (en) 2009-11-19

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