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PE20090597A1 - PHARMACEUTICAL COMPOSITION INCLUDING A DERIVATIVE OF PIRAZOL-O-GLUCOSIDE - Google Patents

PHARMACEUTICAL COMPOSITION INCLUDING A DERIVATIVE OF PIRAZOL-O-GLUCOSIDE

Info

Publication number
PE20090597A1
PE20090597A1 PE2008001383A PE2008001383A PE20090597A1 PE 20090597 A1 PE20090597 A1 PE 20090597A1 PE 2008001383 A PE2008001383 A PE 2008001383A PE 2008001383 A PE2008001383 A PE 2008001383A PE 20090597 A1 PE20090597 A1 PE 20090597A1
Authority
PE
Peru
Prior art keywords
methyl
pirazol
amino
pharmaceutical composition
glucoside
Prior art date
Application number
PE2008001383A
Other languages
Spanish (es)
Inventor
Klaus Dugi
Frank Himmelsbach
Michael Mark
Leo Thomas
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20090597A1 publication Critical patent/PE20090597A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE: A) UN DERIVADO DE PIRAZOL-O-GLUCOSIDO DE FORMULA (I) DONDE R1 ES ALCOXI(C1-C3); L1 Y L2 SON CADA UNO H O F; R6 ES H, ALQUIL(C1-C3)-CARBONILO, FENILOXICARBONILO, ENTRE OTROS; SIENDO COMPUESTOS PREFERIDOS: 4-(2,3-DIFLUORO-4-METOXIBENCIL)-1-ISOPROPIL-5-METIL-3- -D-GLUCOPIRANOS-1-ILOXI-1H-PIRAZOL, 4-(3-FLUORO-4-ETOXIBENCIL)-1-ISOPROPIL-5-METIL-3- -D-GLUCOPIRANOS-1-ILOXI-1H-PIRAZOL, ENTRE OTROS; Y B) UN INHIBIDOR DE DPP IV DE FORMULA (i), (ii), (iii) O (iv), DONDE R1 ES ([1,5]NAFTIRIDIN-2-IL)METILO, (QUINAZOLIN-2-IL)METILO, (QUINOXALIN-6-IL)METILO, ENTRE OTROS; R2 ES 3-(R)-AMINO-PIPERIDIN-1-ILO, (2-AMINO-2-METIL-PROPIL)-METILAMINO O (2-(S)-AMINO-PROPIL)-METILAMINO, ENTRE OTROS; SIENDO COMPUESTOS PREFERIDOS: 1-[(4-METIL-QUINAZOLIN-2-IL)METIL]-3-METIL-7-(2-BUTIN-1-IL)-8-(3-(R)-AMINO-PIPERIDIN-1-IL)-XANTINA, ENTRE OTROS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE DIABETES MELLITUS TIPO 1 Y 2, TOLERANCIA ANORMAL A LA GLUCOSA, HIPERGLUCEMIAIT REFERS TO A PHARMACEUTICAL COMPOSITION CONTAINING: A) A PIRAZOL-O-GLUCOSIDE DERIVATIVE OF FORMULA (I) WHERE R1 IS ALCOXY (C1-C3); L1 AND L2 ARE EACH H OR F; R6 IS H, (C1-C3) -CARBONYL ALKYL, PHENYLOXYCARBONYL, AMONG OTHERS; BEING PREFERRED COMPOUNDS: 4- (2,3-DIFLUORO-4-METOXIBENZOL) -1-ISOPROPYL-5-METHYL-3- -D-GLUCOPYRANES-1-ILOXI-1H-PIRAZOL, 4- (3-FLUORO-4- ETOXYBENZYL) -1-ISOPROPYL-5-METHYL-3- -D-GLUCOPYRANES-1-ILOXI-1H-PIRAZOLE, AMONG OTHERS; AND B) A DPP IV INHIBITOR OF FORMULA (i), (ii), (iii) OR (iv), WHERE R1 IS ([1,5] NAPHTHYRIDIN-2-IL) METHYL, (QUINAZOLIN-2-IL) METHYL , (QUINOXALIN-6-IL) METHYL, AMONG OTHERS; R2 IS 3- (R) -AMINO-PIPERIDIN-1-ILO, (2-AMINO-2-METHYL-PROPYL) -METILAMINO OR (2- (S) -AMINO-PROPYL) -METILAMINO, AMONG OTHERS; BEING PREFERRED COMPOUNDS: 1 - [(4-METHYL-QUINAZOLIN-2-IL) METHYL] -3-METHYL-7- (2-BUTIN-1-IL) -8- (3- (R) -AMINO-PIPERIDIN- 1-IL) -XANTHINE, AMONG OTHERS. SUCH COMPOSITION IS USEFUL IN THE TREATMENT OF TYPE 1 AND 2 DIABETES MELLITUS, ABNORMAL GLUCOSE TOLERANCE, HYPERGLYCAEMIA

PE2008001383A 2007-08-16 2008-08-14 PHARMACEUTICAL COMPOSITION INCLUDING A DERIVATIVE OF PIRAZOL-O-GLUCOSIDE PE20090597A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07114460 2007-08-16

Publications (1)

Publication Number Publication Date
PE20090597A1 true PE20090597A1 (en) 2009-06-06

Family

ID=39828484

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001383A PE20090597A1 (en) 2007-08-16 2008-08-14 PHARMACEUTICAL COMPOSITION INCLUDING A DERIVATIVE OF PIRAZOL-O-GLUCOSIDE

Country Status (4)

Country Link
PE (1) PE20090597A1 (en)
TW (1) TW200911275A (en)
UY (1) UY31291A1 (en)
WO (1) WO2009022008A1 (en)

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CN107115530A (en) 2009-11-27 2017-09-01 勃林格殷格翰国际有限公司 Gene diabetes mellitus type utilizes the treatment of DPP IV inhibitor such as BI 1356
EP2368552A1 (en) 2010-03-25 2011-09-28 Boehringer Ingelheim Vetmedica GmbH 1-[(3-cyano-pyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(r)-amino-piperidin-1-yl]-xanthine for the treatment of a metabolic disorder of a predominantly carnivorous non-human animal
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EP3124041A1 (en) 2010-06-24 2017-02-01 Boehringer Ingelheim International GmbH Diabetes therapy
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TW200911275A (en) 2009-03-16
WO2009022008A1 (en) 2009-02-19
UY31291A1 (en) 2009-03-31

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