PE20090551A1 - Compuestos derivados de ciclooctapirazol como agonistas de los receptores cb2 - Google Patents
Compuestos derivados de ciclooctapirazol como agonistas de los receptores cb2Info
- Publication number
- PE20090551A1 PE20090551A1 PE2008000512A PE2008000512A PE20090551A1 PE 20090551 A1 PE20090551 A1 PE 20090551A1 PE 2008000512 A PE2008000512 A PE 2008000512A PE 2008000512 A PE2008000512 A PE 2008000512A PE 20090551 A1 PE20090551 A1 PE 20090551A1
- Authority
- PE
- Peru
- Prior art keywords
- absent
- cycloalkyl
- alkylene
- cyclooctapirazole
- hexahydro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 101000977048 Streptomyces cinnamonensis Uncharacterized protein in mutB 3'region Proteins 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229930003827 cannabinoid Natural products 0.000 abstract 1
- 239000003557 cannabinoid Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA UN COMPUESTO CICLOOCTAPIRAZOL DE FORMULA (I), DONDE LAS LINEAS DE GUIONES REPRESENTAN ENLACES DOBLES; X1 Y X2 ESTAN AUSENTES O SON ALQUILENO C1-C4; X3 ESTA AUSENTE O ES ALQUILENO C1-C4, ALQUILIDENO C1-C4 O -NH-; X4 ESTA AUSENTE O ES ALQUILENO C1-C4; X5 ESTA AUSENTE O ES ALQUILENO C1-C4; R1 ES H, CICLOALQUILO C3-C12, ENTRE OTROS; R2 ES H, CICLOALQUILO C3-C12, ENTRE OTROS; R3 ES -C(O)-Z1(R6), SO2-NR7-Z2(R8) O -C(O)-NR9-Z3(R10); R4 ES CH-ARILO, CH-HETEROCICLILO, ENTRE OTROS; R5 ES HIDOXI, HALOGENO, AMINO, ENTRE OTROS; R6 ES QRILO, CICLOALQUILO C3-C12, ENTRE OTROS; R7 ES H O ALQUILO C1-C4; R8 ES CICLOALQUILO C3-C12, ARILO, ENTRE OTROS; R9 ES H O ALQUILO C1-C4; R10 ES ARILO, CICLOALQUILO C3-C12, HETEROCICLILO, ENTRE OTROS; Z1 Y Z2 ESTAN AUSENTES O SON ALQUILO C1-C4; Z3 ESTA AUSENTE O ES NH, SO2, ENTER OTROS. SON COMPUESTOS PREFERIDOS: (1,3,3-TRIMETIL-BICICLO[2.2.1]HEPT-2-IL)-AMIDA DEL ACIDO 1-CICLOHEXIL-4,5,6,7,8,9-HEXAHIDRO-1H-CICLOOCTAPIRAZOL-3-CARBOXILICO, (ADAMANTAN-1-ILMETIL)-AMIDA DEL ACIDO 1-CICLOHEXIL-4,5,6,7,8,9-HEXAHIDRO-1H-CICLOOCTAPIRAZOL-3-CARBOXILICO, (ADAMANTAN-1-ILMETIL)-AMIDA DEL ACIDO 1-CICLOPENTIL-4,5,6,7,8,9-HEXAHIDRO-1H-CICLOCTAPIRAZOL-3-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DE LOS RECEPTORES CANNABINOIDES CB2 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89601707P | 2007-03-21 | 2007-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090551A1 true PE20090551A1 (es) | 2009-05-16 |
Family
ID=39766330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000512A PE20090551A1 (es) | 2007-03-21 | 2008-03-19 | Compuestos derivados de ciclooctapirazol como agonistas de los receptores cb2 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2139327A4 (es) |
| JP (1) | JP2010522182A (es) |
| KR (1) | KR20090120500A (es) |
| CN (1) | CN101677555A (es) |
| AR (1) | AR065801A1 (es) |
| AU (1) | AU2008229265A1 (es) |
| CA (1) | CA2681384A1 (es) |
| CL (1) | CL2008000817A1 (es) |
| MX (1) | MX2009010164A (es) |
| PE (1) | PE20090551A1 (es) |
| TW (1) | TW200904414A (es) |
| UY (1) | UY30974A1 (es) |
| WO (1) | WO2008115672A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012090177A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Cannabinoid receptor modulators |
| WO2012090179A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Isoquinoline derivatives as cannabinoid receptor modulators |
| WO2013005168A2 (en) | 2011-07-05 | 2013-01-10 | Lupin Limited | Cannabinoid receptor modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066135A2 (en) * | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
| US7452997B2 (en) * | 2004-03-24 | 2008-11-18 | Janssen Pharmaceutica, N.V. | Tetrahydro-indazole cannabinoid modulators |
| FR2875230A1 (fr) * | 2004-09-13 | 2006-03-17 | Sanofi Aventis Sa | Derives de pyrazole condense, leur preparation et leur application en therapeutique |
| US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| JP5162461B2 (ja) * | 2005-09-23 | 2013-03-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヘキサヒドロシクロオクチルピラゾール系カンナビノイドモジュレーター |
-
2008
- 2008-02-27 KR KR1020097020430A patent/KR20090120500A/ko not_active Withdrawn
- 2008-02-27 JP JP2009554623A patent/JP2010522182A/ja not_active Withdrawn
- 2008-02-27 MX MX2009010164A patent/MX2009010164A/es unknown
- 2008-02-27 CA CA002681384A patent/CA2681384A1/en not_active Abandoned
- 2008-02-27 AU AU2008229265A patent/AU2008229265A1/en not_active Abandoned
- 2008-02-27 EP EP08730822A patent/EP2139327A4/en not_active Withdrawn
- 2008-02-27 WO PCT/US2008/055102 patent/WO2008115672A1/en not_active Ceased
- 2008-02-27 CN CN200880016252A patent/CN101677555A/zh active Pending
- 2008-03-19 PE PE2008000512A patent/PE20090551A1/es not_active Application Discontinuation
- 2008-03-19 AR ARP080101150A patent/AR065801A1/es not_active Application Discontinuation
- 2008-03-19 UY UY30974A patent/UY30974A1/es unknown
- 2008-03-20 TW TW097109757A patent/TW200904414A/zh unknown
- 2008-03-20 CL CL200800817A patent/CL2008000817A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009010164A (es) | 2009-10-12 |
| KR20090120500A (ko) | 2009-11-24 |
| CN101677555A (zh) | 2010-03-24 |
| AR065801A1 (es) | 2009-07-01 |
| UY30974A1 (es) | 2008-09-30 |
| JP2010522182A (ja) | 2010-07-01 |
| AU2008229265A1 (en) | 2008-09-25 |
| TW200904414A (en) | 2009-02-01 |
| WO2008115672A1 (en) | 2008-09-25 |
| EP2139327A4 (en) | 2011-06-15 |
| CA2681384A1 (en) | 2008-09-25 |
| CL2008000817A1 (es) | 2008-09-26 |
| EP2139327A1 (en) | 2010-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |