[go: up one dir, main page]

PE20081184A1 - Agentes tensioactivos reconstituidos que tienen propiedades mejoradas - Google Patents

Agentes tensioactivos reconstituidos que tienen propiedades mejoradas

Info

Publication number
PE20081184A1
PE20081184A1 PE2007001375A PE2007001375A PE20081184A1 PE 20081184 A1 PE20081184 A1 PE 20081184A1 PE 2007001375 A PE2007001375 A PE 2007001375A PE 2007001375 A PE2007001375 A PE 2007001375A PE 20081184 A1 PE20081184 A1 PE 20081184A1
Authority
PE
Peru
Prior art keywords
amino acid
residue
analogue
native
polypeptidic
Prior art date
Application number
PE2007001375A
Other languages
English (en)
Inventor
Jan Johanssson
Tore Curstedt
Bengt Robertson
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39079026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081184(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20081184A1 publication Critical patent/PE20081184A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

REFERIDA A UN AGENTE TENSIOACTIVO RECONSTITUIDO QUE COMPRENDE UN VEHICULO LIPIDICO Y UNA COMBINACION DE UN ANALOGO POLIPEPTIDICO DE LA PROTEINA TENSIOACTIVA NATIVA SP-C CON UN ANALOGO POLIPEPTIDICO DE LA PROTEINA TENSIOACTIVA NATIVA SP-B, DONDE EL ANALOGO POLIPEPTIDICO DE LA PROTEINA TENSIOACTIVA NATIVA SP-C ES UN POLIPEPTIDO DE 20 A 40 RESIDUOS DE AMINOACIDOS DE FORMULA (I), DONDE X ES UN RESIDUO DE AMINOACIDO SELECCIONADO DE I, L Y nL, B ES UN RESIDUO DE AMINOACIDO SELECCIONADO DE K, W, F, Y Y Orn, S ESTA OPCIONALMENTE SUSTITUIDO CON GRUPOS ACILOS DE 12 A 22 CARBONOS, OMEGA ES UN RESIDUO DE AMINOACIDO SELECCIONADO DE M O SU DERIVADO OXIDADO EN EL ATOMO DE AZUFRE, I, L Y nL, a ES UN ENTERO DE 1 A 8, b ES UN ENTERO DE 1 A 19, c E UN ENTERO DE 3 A 8, e, f, g Y p SON 0 O 1, n ES UN ENTERO DE 0 A 3; Y EL ANALOGO POLIPEPTIDICO DE LA PROTEINA TENSIOACTIVA NATIVA SP-B TIENE LA FORMULA (II), DONDE DELTA ES UN RESIDUO DE AMINOACIDO SELECCIONADO DE W Y L, OMEGA ES UN RESIDUO DE AMINOACIDO SELECCIONADO DE M, I, L Y nL, PHI ES UN RESIDUO DE AMINOACIDO SELECCIONADO DE R Y T, f ES 0 O 1. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DEL SINDROME DE DIFICULTAD RESPIRATORIA (RDS)
PE2007001375A 2006-10-13 2007-10-11 Agentes tensioactivos reconstituidos que tienen propiedades mejoradas PE20081184A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06021521 2006-10-13

Publications (1)

Publication Number Publication Date
PE20081184A1 true PE20081184A1 (es) 2008-09-26

Family

ID=39079026

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001375A PE20081184A1 (es) 2006-10-13 2007-10-11 Agentes tensioactivos reconstituidos que tienen propiedades mejoradas

Country Status (35)

Country Link
US (2) US8183210B2 (es)
EP (1) EP2078038B1 (es)
JP (2) JP5405307B2 (es)
KR (1) KR101328851B1 (es)
CN (2) CN103169947B (es)
AR (2) AR063263A1 (es)
AU (1) AU2007306075B2 (es)
BR (1) BRPI0715317B1 (es)
CA (1) CA2666344C (es)
CL (1) CL2007002931A1 (es)
CO (1) CO6400235A2 (es)
CY (1) CY1114716T1 (es)
DK (1) DK2078038T3 (es)
EA (1) EA015802B1 (es)
ES (1) ES2438727T3 (es)
GE (1) GEP20125531B (es)
HR (1) HRP20140052T1 (es)
IL (1) IL198075A (es)
JO (1) JO2963B1 (es)
MA (1) MA31062B1 (es)
ME (2) ME02326B (es)
MX (1) MX343064B (es)
MY (1) MY148127A (es)
NO (1) NO342038B1 (es)
NZ (1) NZ576189A (es)
PE (1) PE20081184A1 (es)
PL (1) PL2078038T3 (es)
PT (1) PT2078038E (es)
RS (1) RS53172B (es)
SI (1) SI2078038T1 (es)
TN (1) TN2009000099A1 (es)
TW (1) TWI388333B (es)
UA (1) UA94477C2 (es)
WO (1) WO2008044109A1 (es)
ZA (1) ZA200902481B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008011559A2 (en) 2006-07-20 2008-01-24 University Of Rochester Synthetic lung surfactant and use thereof
EP1997502A1 (en) * 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties
US8399406B2 (en) * 2009-06-05 2013-03-19 Chiesi Farmaceutici S.P.A. Reconstituted surfactant composition containing analogs of surfactant protein B (SP-B) and surfactant protein C (SP-C)
CN101948526B (zh) * 2010-09-02 2012-12-05 华东理工大学 一种肺泡表面活性蛋白质(sp-b和sp-c)的分离纯化方法
WO2013120058A2 (en) * 2012-02-09 2013-08-15 University Of Rochester Novel sp-b & sp-c peptides, synthetic lung surfactants, and use thereof
US20130303726A1 (en) 2012-04-17 2013-11-14 Chiesi Farmaceutici S.P.A. Method for the preparation of surfactant peptides
WO2014079898A1 (en) 2012-11-21 2014-05-30 Chiesi Farmaceutici S.P.A. Reconstituted pulmonary surfactants
US10717777B2 (en) 2015-12-17 2020-07-21 The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Synthetic lung surfactant with enhanced stability and effectiveness
CA3016810C (en) 2016-03-07 2024-04-02 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Compositions and methods for administering ppar.gamma. agonists, surfactant peptides and phospholipids
KR102395835B1 (ko) * 2016-08-24 2022-05-10 키에시 파르마슈티시 엣스. 피. 에이. 재구성된 폐 계면활성제 조성물을 포함하는 안정한 약제학적 제제
WO2021151853A1 (en) 2020-01-28 2021-08-05 Chiesi Farmaceutici S.P.A. Polypeptides having improved properties
JP2023546297A (ja) * 2020-10-16 2023-11-01 バイオスーペリア テクノロジー，インコーポレイテッド 肺治療組成物
WO2025024609A1 (en) * 2023-07-25 2025-01-30 Biosuperior Technology, Inc. Polypeptides for lung surfactant compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08512056A (ja) * 1993-06-30 1996-12-17 ジェネンテク・インコーポレイテッド リポソームの製造法
IT1308180B1 (it) * 1999-02-12 2001-12-07 Chiesi Farma Spa Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante
US7065342B1 (en) * 1999-11-23 2006-06-20 Gofigure, L.L.C. System and mobile cellular telephone device for playing recorded music
ITMI20021058A1 (it) * 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
WO2008011559A2 (en) * 2006-07-20 2008-01-24 University Of Rochester Synthetic lung surfactant and use thereof
EP1997502A1 (en) * 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties
EP2022798A1 (en) 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides

Also Published As

Publication number Publication date
EA015802B1 (ru) 2011-12-30
BRPI0715317B1 (pt) 2021-10-05
US20100004173A1 (en) 2010-01-07
MEP12109A (en) 2011-12-20
PT2078038E (pt) 2013-12-12
TWI388333B (zh) 2013-03-11
ME02326B (me) 2016-06-20
TN2009000099A1 (en) 2010-08-19
AR113422A2 (es) 2020-04-29
BRPI0715317A2 (pt) 2013-07-09
US8183210B2 (en) 2012-05-22
ZA200902481B (en) 2010-07-28
AU2007306075B2 (en) 2012-08-09
EP2078038A1 (en) 2009-07-15
US20130079275A1 (en) 2013-03-28
CN101522711B (zh) 2013-11-13
KR20090083892A (ko) 2009-08-04
KR101328851B1 (ko) 2013-11-14
NO342038B1 (no) 2018-03-19
CN103169947B (zh) 2014-10-29
CO6400235A2 (es) 2012-03-15
EP2078038B1 (en) 2013-11-20
CY1114716T1 (el) 2016-10-05
NO20091441L (no) 2009-06-23
MX2009003638A (es) 2009-04-22
CA2666344C (en) 2017-04-18
MX343064B (es) 2016-10-24
US9238058B2 (en) 2016-01-19
IL198075A (en) 2016-04-21
TW200824705A (en) 2008-06-16
GEP20125531B (en) 2012-05-25
HK1134497A1 (en) 2010-04-30
UA94477C2 (ru) 2011-05-10
JO2963B1 (en) 2016-03-15
HRP20140052T1 (hr) 2014-02-28
WO2008044109A1 (en) 2008-04-17
JP5405307B2 (ja) 2014-02-05
MA31062B1 (fr) 2010-01-04
EA200900373A1 (ru) 2009-10-30
DK2078038T3 (da) 2013-12-02
CA2666344A1 (en) 2008-04-17
IL198075A0 (en) 2011-08-01
CN103169947A (zh) 2013-06-26
HK1185274A1 (en) 2014-02-14
CL2007002931A1 (es) 2008-03-24
AR063263A1 (es) 2009-01-14
AU2007306075A1 (en) 2008-04-17
PL2078038T3 (pl) 2014-05-30
MY148127A (en) 2013-02-28
JP2013241449A (ja) 2013-12-05
NZ576189A (en) 2011-09-30
RS53172B (sr) 2014-06-30
SI2078038T1 (sl) 2014-02-28
ES2438727T3 (es) 2014-01-20
CN101522711A (zh) 2009-09-02
JP2010505937A (ja) 2010-02-25

Similar Documents

Publication Publication Date Title
PE20081184A1 (es) Agentes tensioactivos reconstituidos que tienen propiedades mejoradas
EA200901459A1 (ru) Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства
ATE509618T1 (de) Nanoteilchenförmige zusammensetzungen mit einem peptid als oberflächenstabilisator
ATE282635T1 (de) Glp-1 analoge
BRPI1010120A2 (pt) composição de surfactante reconstituído melhorada contendo análogos de proteína b do surfactante (sp-b) e proteína c do surfactante ( sp-c)
ATE549028T1 (de) Stabile analoga von glp-1
ECSP077829A (es) Péptidos y péptidos miméticos para tratar patologías caracterizadas por una respuesta inflamatoria
DE69938669D1 (de) Analoge des glucagon ähnlichen peptides-1 (glp-1)
AR075908A1 (es) Formulacion farmaceutica que contiene moleculas de anticuerpo mejoradas, polipeptidos. metodo para estabilizar solucion, anticuerpo.
DE60332212D1 (de) Arzneistoffnanopartikel mit lysozym-oberflächenstabilisator
PH12019550241A1 (en) Mic-1 compounds and uses thereof
PE20020992A1 (es) Conjugados peg de hgf-nk4
MX2024011099A (es) Conjugados de farmaco unido a anticuerpo anti-glp1r que comprenden peptidomimeticos de glp1 y usos de los mismos.
NO20080552L (no) GLP-1 farmasoytiske sammensetninger
ATE503768T1 (de) Synthetische lungensurfactant peptide
NO20063521L (no) Blandinger, fremgangsmater og anvendelser av en ny peptidfamilie
MX2022003598A (es) Composicion farmaceutica, que comprende la proteina galectina 9 recombinante estabilizada, para la prevencion o el tratamiento de la artritis reumatoide y enfermedades oseas.
ATE471341T1 (de) Insulinotrope verbindungen und anwendungen davon
FR2868427A1 (fr) Composition non inflammable et son utilisation
TH84559B (th) อะนาล็อกของพอลิมัยซิน b สำหรับการสลายพิษ lps

Legal Events

Date Code Title Description
FG Grant, registration