[go: up one dir, main page]

PE20081793A1 - Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona - Google Patents

Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona

Info

Publication number
PE20081793A1
PE20081793A1 PE2008000403A PE2008000403A PE20081793A1 PE 20081793 A1 PE20081793 A1 PE 20081793A1 PE 2008000403 A PE2008000403 A PE 2008000403A PE 2008000403 A PE2008000403 A PE 2008000403A PE 20081793 A1 PE20081793 A1 PE 20081793A1
Authority
PE
Peru
Prior art keywords
pyridazin
preparation
phenylisoxazole
methyl
hydrazine
Prior art date
Application number
PE2008000403A
Other languages
English (en)
Inventor
Masia Xavier Serra
Hereu Iolanda Marchueta
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of PE20081793A1 publication Critical patent/PE20081793A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DEL COMPUESTO 3-METIL-4-FENILISOXAZOLO[3,4-d]PIRIDAZIN-7(6H)-ONA, QUE COMPRENDE: A) HACER REACCIONAR 1-FENILBUTAN-1,3-DIONA CON 2-CLORO-2-(HIDROXIIMINO)ACETATO DE ETILO, CARACTERIZADO POR QUE SE REALIZA MEDIANTE LA ADICION DE METOXIDO SODICO SEGUIDO DE LA ADICION DE 2-CLORO-2-(HIDROXIIMINO)ACETATO DE ETILO Y LA REACCION MOLAR ENTRE EL PRIMERO Y ULTIMO ESTA COMPRENDIDA ENTRE 1,05 Y 1,15; B) HACER REACCIONAR HIDRAZINA O UN HIDRATO DE LA MISMA SOBRE LA MEZCLA RESULTANTE DE LA ETAPA ANTERIOR, CARACTERIZADO POR QUE LA RELACION MOLAR ENTRE LA HIDRAZINA Y EL COMPUESTO INICIAL ESTA COMPRENDIDA ENTRE 1,15 Y 1,25. DICHO PROCEDIMIENTO PROVEE A UN INTERMEDIO EN LA PREPARACION DE ALGUNOS DERIVADOS DE PIRIDAZIN-3(2H)-ONA. DICHO PROCEDIMIENTO PERMITE OBTENER EL COMPUESTO CON MAYORES RENDIMIENTOS
PE2008000403A 2007-03-02 2008-02-28 Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona PE20081793A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200700564A ES2320954B1 (es) 2007-03-02 2007-03-02 Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.

Publications (1)

Publication Number Publication Date
PE20081793A1 true PE20081793A1 (es) 2008-12-18

Family

ID=38617235

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000403A PE20081793A1 (es) 2007-03-02 2008-02-28 Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona

Country Status (23)

Country Link
US (1) US20100137591A1 (es)
EP (1) EP2125830B1 (es)
JP (1) JP2010520158A (es)
KR (1) KR20090116753A (es)
CN (1) CN101679453A (es)
AR (1) AR065511A1 (es)
AT (1) ATE496923T1 (es)
AU (1) AU2008224206A1 (es)
BR (1) BRPI0807273A2 (es)
CA (1) CA2679619A1 (es)
CL (1) CL2008000598A1 (es)
DE (1) DE602008004742D1 (es)
EC (1) ECSP099558A (es)
ES (1) ES2320954B1 (es)
IL (1) IL200166A0 (es)
MX (1) MX2009009232A (es)
NZ (1) NZ578671A (es)
PE (1) PE20081793A1 (es)
RU (1) RU2009136314A (es)
TW (1) TW200844105A (es)
UY (1) UY30913A1 (es)
WO (1) WO2008107064A1 (es)
ZA (1) ZA200905193B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679696A (en) * 1992-07-28 1997-10-21 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
DE19540475A1 (de) * 1995-10-20 1997-04-24 Schering Ag Chirale Methylphenyloxazolidinone
DE69738949D1 (de) * 1996-05-20 2008-10-09 Darwin Discovery Ltd Chinolincarboxamide als tnf-inhibitoren und als pde-iv inhibitoren
US5972936A (en) * 1996-05-20 1999-10-26 Darwin Discover Limited Benzofuran carboxamides and their therapeutic use
WO1999026616A1 (en) * 1997-11-25 1999-06-03 Warner-Lambert Company Benzenesulfonamide inhibitors of pde-iv and their therapeutic use
JP2002537383A (ja) * 1999-02-25 2002-11-05 メルク フロスト カナダ アンド カンパニー Ｐｄｅｉｖ阻害化合物、組成物および治療方法
US6699890B2 (en) * 2000-12-22 2004-03-02 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
KR20090080573A (ko) * 2001-10-16 2009-07-24 메모리 파마슈티칼스 코포레이션 신경계 증후군의 치료를 위한 ｐｄｅ-4 억제제로서의 4-(4-알콕시-3-히드록시페닐)-2-피롤리돈 유도체
MY130622A (en) * 2001-11-05 2007-07-31 Novartis Ag Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
ES2195785B1 (es) * 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
MXPA05005345A (es) * 2002-11-19 2005-08-26 Memory Pharm Corp Inhibidores de fosfodiesterasa 4.
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
AU2004232973A1 (en) * 2003-04-18 2004-11-04 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
ES2232306B1 (es) * 2003-11-10 2006-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251866B1 (es) * 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
CN103351390A (zh) * 2007-11-21 2013-10-16 解码遗传Ehf公司 用于治疗肺部和心血管病症的联芳基pde4 抑制剂

Also Published As

Publication number Publication date
EP2125830B1 (en) 2011-01-26
ECSP099558A (es) 2009-09-29
CN101679453A (zh) 2010-03-24
AU2008224206A1 (en) 2008-09-12
US20100137591A1 (en) 2010-06-03
UY30913A1 (es) 2008-07-31
ZA200905193B (en) 2010-05-26
ES2320954A1 (es) 2009-05-29
AR065511A1 (es) 2009-06-10
ES2320954B1 (es) 2010-03-16
MX2009009232A (es) 2009-10-12
CA2679619A1 (en) 2008-09-12
EP2125830A1 (en) 2009-12-02
CL2008000598A1 (es) 2008-09-05
NZ578671A (en) 2011-04-29
RU2009136314A (ru) 2011-04-10
WO2008107064A1 (en) 2008-09-12
IL200166A0 (en) 2010-04-15
DE602008004742D1 (de) 2011-03-10
TW200844105A (en) 2008-11-16
JP2010520158A (ja) 2010-06-10
ATE496923T1 (de) 2011-02-15
KR20090116753A (ko) 2009-11-11
BRPI0807273A2 (pt) 2014-04-29

Similar Documents

Publication Publication Date Title
USD620382S1 (en) Watch dial
TW200626559A (en) Anilino-pyrimidine analogs
UA95095C2 (en) 11 beta-hydroxyandrosta-1,4-diene-3-ones
MX2007005694A (es) Nuevos derivados de betulina, preparacion y uso de los mismos.
GB0418900D0 (en) Novel salt forms
PT2242743E (pt) Derivados de aminopirazol
ECSP099073A (es) Nuevos derivados de piridazina
MX2007004215A (es) Proceso para la sintesis de 4-(3-metansulfonilfenil)-1-n- propilpiperidina.
TW200621737A (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
MX2009007713A (es) Derivados de piridazina, procedimientos para su preparacion y su uso como fungicidas.
TW200612958A (en) Substituted imidazole derivatives
TNSN06405A1 (en) Quinazolinone derivatives useful as vanilloid antagonistes
ZA200810347B (en) Phenyl pyrrole aminoguanidine derivatives
ECSP066911A (es) Polimorfo cristalino de un acetato de bazedoxifeno
AR116001A2 (es) Composición farmacéutica 271
TW200740814A (en) Compounds
ECSP066910A (es) Polimorfo cristalino de acetato de bazedoxifeno
PE20081793A1 (es) Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona
ECSP066912A (es) Formulaciones de dispersiones sólidas de acetato de bazedoxifeno
MY152557A (en) 3-aminocyclopentanecarboxamides as chemokine receptor modulators
IL195837A0 (en) 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]
NO20074869L (no) Pyrimidinderivater for anvendelse som antikreftmidler
TW200716564A (en) Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
MY146622A (en) N-phenylpyrazole derivatives as pesticides
AR063597A1 (es) Nueva sal

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed